Mammalian target of rapamycin inhibitors: A new‐possible approach for in‐utero medication therapy
Shohra Qaderi,
Ali Javinani,
Yair J. Blumenfeld
et al.
Abstract:The mammalian/mechanistic target of rapamycin (mTOR) is a protein kinase that plays a crucial role in regulating cellular growth, metabolism, and survival. Although there is no absolute contraindication for the use of mTOR inhibitors during pregnancy, the specific fetal effects remain unknown. Available data from the past 2 decades have examined the use of mTOR inhibitors during pregnancy in patients with solid organ transplantation, showing no clear link to fetal complications or structural abnormalities. Rec… Show more
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