Mammalian sulfoconjugate metabolism

Chemoselective Synthesis and Anti-Kinetoplastidal Properties of 2,6-Diaryl-4H-tetrahydro-thiopyran-4-one S-Oxides: Their Interplay in a Cascade of Redox Reactions from Diarylideneacetones

“…It is well documented that S-oxides can undergo β-elimination, resulting in the formation of a double bond through pericyclic [25,26], ionic, photolytic, or radical mechanisms [27][28][29][30][31] (Scheme 3). Once integrated into organic compounds, the sulfur atom, with its several degrees of oxidation, will be submitted to many and varied metabolic fates in living cells through different mechanisms [32][33][34][35][36][37][38][39][40][41]. In the field of organic chemistry, the synthesis and the reactivity of sulfur-containing compounds have also been extensively exploited to generate double bonds, as described in the literature [32][33][34][35][36][37][38][39][40][41].…”

“…Once integrated into organic compounds, the sulfur atom, with its several degrees of oxidation, will be submitted to many and varied metabolic fates in living cells through different mechanisms [32][33][34][35][36][37][38][39][40][41]. In the field of organic chemistry, the synthesis and the reactivity of sulfur-containing compounds have also been extensively exploited to generate double bonds, as described in the literature [32][33][34][35][36][37][38][39][40][41]. In particular, it is well known that sulfoxide and sulfone can undergo β-elimination, thus resulting in the formation of a double bond (Scheme 3).…”