Mammalian phytoestrogens: enterodiol and enterolactone

Wang, Liquan

doi:10.1016/s1570-0232(02)00281-7

Cited by 203 publications

(172 citation statements)

References 113 publications

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“…Flax is reported to be protective against mammary, prostate and colon cancer in animal models. [14][15][16][17]32 The present findings suggest that FIGURE 5 -(a) BRCA1 and (b) p53 mRNA expression and (c) p53 protein expression in the mammary glands of 8-week-old rats whose mothers were exposed to a diet containing cellulose (control), oat flour, whole wheat flour or defatted flaxseed flour during pregnancy. Values represent the mean of 6 rats per group 6 SEM.…”

Section: Discussionmentioning

confidence: 51%

Maternal dietary exposure to fiber during pregnancy and mammary tumorigenesis among rat offspring

Khan

Foxworth

et al. 2006

Intl Journal of Cancer

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Maternal diet during pregnancy has been proposed to modify female offspring's later susceptibility to develop breast cancer; however, most of the dietary factors identified thus far have led to increased risk. To identify dietary factors that might reduce offspring's breast cancer risk, pregnant rat dams were fed diets containing 6% fiber originating either from cellulose (control), or oat, whole wheat or defatted flax flour. At birth, dams were switched to the AIN93 semi-purified diet. Mammary tumor incidence and multiplicity, induced by administering the offspring 5 mg 7,12-dimethylbenz[a]anthracene (DMBA) at the age of 50 days, was reduced in the whole wheat flour-exposed offspring and increased in the defatted flax-exposed offspring. To identify the mechanisms mediating the effects of in utero dietary exposures, changes in mammary gland morphology and gene expression were assessed before puberty onset (3 weeks of age) and at the time rats are most susceptible to malignant transformation (8 weeks of age). The number of terminal end buds (TEBs), i.e., the targets of malignant transformation, was reduced in the mammary glands of whole wheat-and oat flour-exposed offspring, as compared to the controls. Further, the number of apoptotic epithelial cells (based on ISOL assay) was elevated in the whole wheat flour offspring, but no changes in cell proliferation (PCNA), estrogen receptor a (ERa) or cyclin D1 mRNA or protein levels were seen. The mRNA and/or protein levels of BRCA1 and p53 were significantly increased in the mammary glands of whole wheat flour offspring. Further, the levels of 8-hydroxy-2 0 -deoxyguanosine (8-OHdG), a marker of DNA damage, were significantly reduced in these rats, suggesting that maternal dietary exposure to whole wheat during pregnancy may reduce offspring's breast cancer risk by improving DNA damage repair mechanisms. ' 2006 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 51%

Maternal dietary exposure to fiber during pregnancy and mammary tumorigenesis among rat offspring

Khan

Foxworth

et al. 2006

Intl Journal of Cancer

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“…To our knowledge, the estrogenic or antiestrogenic effects of enterolignans in humans are not very clear (142). For example, while weak estrogenic activity of ENL was demonstrated the anti-estrogenic activity of ENL was disclosed through depression of estrogen-stimulated rat uterine RNA synthesis (143).…”

Section: Anticancer Activitymentioning

confidence: 99%

Phytochemicals in Soy and Their Health Effects

Wu¹,

Kang²

2011

Phytochemicals - Bioactivities and Impact on Health

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“…Dietary lignans, particularly secoisolariciresinol diglucoside (SDG), are of interest because they have been proposed to play a role in the prevention of breast and colon cancer, atherosclerosis and diabetes (Wang, 2002). Previous studies in non-ruminant animals have indicated that the plant lignans per se are devoid of any biological properties, and that only the mammalian lignans enterodiol (END) and enterolactone (ENL), produced from SDG by intestinal bacteria, have interesting biological properties such as oestrogen agonism and antagonism as well as antioxidative and enzyme-inhibiting activities (Clavel et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies in non-ruminant animals have indicated that the plant lignans per se are devoid of any biological properties, and that only the mammalian lignans enterodiol (END) and enterolactone (ENL), produced from SDG by intestinal bacteria, have interesting biological properties such as oestrogen agonism and antagonism as well as antioxidative and enzyme-inhibiting activities (Clavel et al, 2005). Earlier studies in rats and humans had established that SDG could be metabolized to END, probably through hydrolysis, dehydroxylation and then demethylation by facultative bacteria, and then ENL was produced from END through oxidation by faculatative bacteria (Wang, 2002); however the bacterial convertation of SDG in rumen have not been reported.…”

Section: Introductionmentioning

confidence: 99%

The metabolism of linseed lignans in rumen and its impact on ruminal metabolism in male goats

Zhou¹,

Zhengkang²,

Zhu³

2009

J. Anim. Feed Sci.

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To investigate the metabolism of linseed lignans in the rumen and its impact on ruminal metabolism, four healthy male Huainan goats were used in a crossover study. Following secoisolariciresinol diglucoside (SDG) crude extract treatment, the concentrations of SDG, enterodiol (END) and enterolactone (ENL) in both ruminal fl uid and serum were signifi cantly increased (P<0.01). Concomitantly, the pH value and ammonia-nitrogen concentration of ruminal fl uid were decreased (P<0.05), and the concentrations of microbial crude protein and total volatile fatty acids were increased (P<0.01). Furthermore, testosterone and 3, 3′, 5-triiodothyronine levels in serum and ruminal fl uid were both signifi cantly increased, while the concentration of E 2 in ruminal fl uid was decreased. Based on these observations, it is suggested that ruminal microorganisms were able to effi ciently convert SDG to END and ENL, which were absorbed immediately. In return, SDG and/or its metabolites may facilitate the utilization of non-protein nitrogen and carbohydrates in the rumen.

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Mammalian phytoestrogens: enterodiol and enterolactone

Cited by 203 publications

References 113 publications

Maternal dietary exposure to fiber during pregnancy and mammary tumorigenesis among rat offspring

Maternal dietary exposure to fiber during pregnancy and mammary tumorigenesis among rat offspring

Phytochemicals in Soy and Their Health Effects

The metabolism of linseed lignans in rumen and its impact on ruminal metabolism in male goats

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