Mammalian Pax Genes

Stuart, Edward T.; Kioussi, Chrissa; Gruß, Peter

doi:10.1146/annurev.ge.28.120194.001251

Cited by 132 publications

(92 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the pancreas, PAX4 and PAX6 gene expression is confined to endocrine precursor cells, suggesting that PAX4 and PAX6 are required during early steps to generate specific endocrine cells of the pancreas. 16,28 Very little is known about the role of PAX8 in islet cell Our study shows that PAX8 immunohistochemistry is strongly expressed in pancreatic neuroendocrine tumors and its metastases. In contrast, PAX8 was not observed in ileal or pulmonary well-differentiated neuroendocrine tumors, whereas other gastrointestinal neuroendocrine tumors, particularly those of the duodenum, stomach, and rectum, may demonstrate PAX8 immunoreactivity.…”

Section: Pax8 Expression In Neuroendocrine Tumorsmentioning

confidence: 70%

“…14,15 In particular, PAX4 and PAX6 are essential for development of pancreatic islet cells as well as endocrine cell development in the small intestine and stomach. [14][15][16] Although PAX8 has been most studied in renal tissues and neoplasms, 17 it has been recently recognized as a useful marker in distinguishing ovarian from breast carcinoma, 18 and as a marker of thyroid epithelial neoplasms. 19 Moreover, our group recently observed intense PAX8 reactivity in pancreatic neuroendocrine tumors and normal pancreatic islets in a large tissue microarray evaluation of PAX8 immunoreactivity of non-renal tissues/neoplasms.…”

mentioning

confidence: 99%

See 1 more Smart Citation

PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma

et al. 2011

View full text Add to dashboard Cite

PAX (paired box) genes encode a family of transcription factors that regulate organogenesis in a variety of organs. Very little is known about the role of PAX8 in endocrine cell development and the expression of PAX8 in neuroendocrine tumors. The purpose of this study was to analyze PAX8 immunohistochemical expression in gastroenteropancreatic and pulmonary well-differentiated neuroendocrine tumors to determine whether PAX8 can reliably distinguish pancreatic neuroendocrine tumors from neuroendocrine tumors of other anatomic sites and other pancreatic non-ductal neoplasms. In total, 221 well-differentiated neuroendocrine tumors were evaluated: 174 primary neuroendocrine tumors (66 pancreatic, 31 ileal, 21 pulmonary, 20 gastric, 17 rectal, 11 appendiceal, and 8 duodenal) and 47 neuroendocrine tumors metastatic to the liver (31 pancreatic, 11 ileal, 2 pulmonary, 2 duodenal, and 1 rectal). Fifteen solid-pseudopapillary neoplasms and six acinar cell carcinomas of the pancreas were also evaluated. PAX8 was positive in 49/66 (74%) primary pancreatic neuroendocrine tumors. PAX8 expression did not correlate with World Health Organization categorization, grade, size, functional status, or the presence of liver or lymph node metastasis. PAX8 expression was identified in 0/31 (0%) ileal, 0/21 (0%) pulmonary, 2/20 (10%) gastric, 5/17 (29%) rectal, 1/11 (9%) appendiceal, and 6/8 (75%) duodenal neuroendocrine tumors. PAX8 was positive in 4/15 (27%) solid-pseudopapillary neoplasms of the pancreas, whereas all acinar cell carcinomas (0/6) lacked immunoreactivity. Among liver metastases, only pancreatic neuroendocrine tumors (20/31, 65%) were PAX8 positive, whereas no cases of ileal (0/11), pulmonary (0/2), duodenal (0/2), and rectal (0/1) neuroendocrine tumor metastases were PAX8 positive. PAX8 is expressed in primary and metastatic pancreatic well-differentiated neuroendocrine tumors, and its expression can reliably distinguish pancreatic from ileal and pulmonary well-differentiated neuroendocrine tumors. Duodenal neuroendocrine tumors and a subset of rectal, gastric, and appendiceal neuroendocrine tumors may also express PAX8. PAX8 expression can distinguish pancreatic neuroendocrine tumors from acinar cell carcinomas, but its utility in distinguishing neuroendocrine tumors from solid-pseudopapillary neoplasms is limited.

show abstract

Section: Pax8 Expression In Neuroendocrine Tumorsmentioning

confidence: 70%

mentioning

confidence: 99%

PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The expression pattern of different members of the Id gene family shares some similarity with that of members of other multi-gene families, such as PAX (reviewed by Stuart et al, 1994) and Bone Morphogenetic Protein (BMP) (Fukagawa et al, 1994;Jones et al, 1991;Lyons et al, 1989Lyons et al, ,1990Lyons et al, , 1995Wall et al, 1993). BMP-2 is worth special mention: BMP-2 is a member of the bone morphogenetic proteins (BMP) family which is capable of inducing cartilage and bone formation in bioassays.…”

Section: Discussionmentioning

confidence: 99%

Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis

1996

View full text Add to dashboard Cite

The murine dominant negative helix-loop-helix (dnHLH) proteins inhibit the activities of bHLH transcription factors in diverse cell lineages (Benezra et al. . Currently, there are four members in the dnHLH family, Idl, Id2, Id3, and Id4. In this report, we have performed a detailed comparative in situ hybridization analysis to examine their expression pattern during post-gastrulational mouse development. Idl, 2, and 3 are expressed in multiple tissues, whereas Id4 expression can only be detected in neuronal tissues and in the ventral portion of the epithelium of the developing stomach. The regions where I d 1 3 genes are expressed, such as gut, lung, kidney, tooth, whisker, and several glandular structures, are undergoing active morphogenetic activities. The expression patterns of Idl, 2, and 3 overlap in many organs, except in the tissues derived from primitive gut. In the latter, Id1 and Id3 signals are detected in the mesenchyme surrounding the epithelium, whereas Id2 is expressed within the epithelium. The difference in the patterns of expressions of I d 1 3 and Id4 suggest that the dominant negative transcriptional activity of these two subclasses of the Id family may have different physiological consequences. o 1996 Witey-Liss, Inc.

show abstract

“…Pax proteins form a family of transcription factors which are essential for a variety of developmental decisions during embryogenesis [1][2][3][4]. Pax proteins are defined by the presence of a 128-amino-acid-long DNA-binding domain, the paired domain (Prd domain) [5].…”

Section: Introductionmentioning

confidence: 99%

Co-operation between the PAI and RED subdomains of Pax-8 in the interaction with the thyroglobulin promoter

Pellizzari

Tell

Damante

1999

Biochemical Journal

View full text Add to dashboard Cite

Pax proteins are transcription factors that play an important role in the differentiation of several cell types. These proteins bind to specific DNA sequences through the paired domain. This evolutionarily conserved element is composed of two subdomains (PAI and RED), located at the N-and C-terminals, respectively. Due to the presence of these two subdomains, Pax proteins may recognize DNA in different modes, a possibility that has not been exhaustively explored yet. The C site of the thyroglobulin promoter is bound by the thyroid-specific transcription factor Pax-8. In this study we have characterized the mode by which the Pax-8 paired domain interacts with the C site. Results allow the identification of the respective positions of the PAI and RED subdomains when the full-length protein is bound to the C site. The binding of the isolated PAI and RED subdomains to the C site and to several related mutants was also evaluated. Both subdomains interact with DNA as a monomer and display a

show abstract

Mammalian Pax Genes

Cited by 132 publications

References 32 publications

PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma

PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma

Expression patterns of Id1, Id2, and Id3 are highly related but distinct from that of Id4 during mouse embryogenesis

Co-operation between the PAI and RED subdomains of Pax-8 in the interaction with the thyroglobulin promoter

Contact Info

Product

Resources

About