Mammalian organ regeneration in spiny mice

Okamura, Daryl M.; Nguyen, Elizabeth Dong; Collins, Sarah; Yoon, Kevin; Gere, Joshua B.; Weiser‐Evans, Mary C.M.; Beier, David R.; Majesky, Mark W.

doi:10.1007/s10974-022-09631-3

Cited by 3 publications

(3 citation statements)

References 131 publications

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“…Additionally, there are reports of regeneration after ischemic and visceral injuries in the kidneys, heart, muscles, and spinal cord. This genus is an exception, as the high level of regenerative complexity is not observed in other mammals (Okamura et al, 2023).…”

Section: Animal Regenerationmentioning

confidence: 93%

Advances in Biotechnology for Cellular and Tissue Regeneration: Challenges and Perspectives in Human Disease Treatment

Pavan,

Giacinti,

Alvarenga

et al. 2024

RECIMA21

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Biotechnology constitutes a realm of inquiry that extends its benefits across diverse domains of knowledge, ranging from agricultural sciences to clinical applications. This field leverages technology to address challenges frequently entailing living organisms. Of current significance is the endeavor to elucidate the process of animal regeneration, particularly within the human species, given its burgeoning potential as an ally in the treatment and cure of various maladies. Recognizing the societal importance of this subject, the present article seeks to expound upon contemporary biotechnological advancements facilitating the exploration of cellular and tissue regeneration for the treatment of human diseases. To this end, a comprehensive review of articles delineating the current landscape was conducted, involving a comparative analysis of regenerative activity across species, with a specific focus on humans. Evidentially, the use of biomaterials in tissue regeneration assumes paramount importance, albeit not without the formidable challenge posed by the inflammatory process. Stem cells, conversely, present themselves as promising entities in the realm of regeneration. However, their interaction within the host organism necessitates further scrutiny to attain a more nuanced understanding. Despite strides made in the field of regenerative medicine, the lack of comprehensive comprehension regarding the properties of biomaterials and their responses within the human body constrains their clinical applicability. Nevertheless, an auspicious future is envisioned, marked by advancements in biomaterials and a heightened understanding of interactions within the human body, thereby fostering the development of more efficacious treatments for a myriad of diseases.

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Section: Animal Regenerationmentioning

confidence: 93%

Advances in Biotechnology for Cellular and Tissue Regeneration: Challenges and Perspectives in Human Disease Treatment

Pavan,

Giacinti,

Alvarenga

et al. 2024

RECIMA21

View full text Add to dashboard Cite

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“…Among terrestrial organisms, there are exceptional cases of tail regeneration in lizards (Jacyniak et al., 2017) and skin regeneration in the spiny mouse (Okamura et al., 2023). These properties are proposed as evolutionary strategies to evade predators, regenerating severe wounds without fibrotic scars.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, there is regeneration of brain tissue and the optic nerve in lizards (Jacyniak et al., 2017). In addition, although spiny mice are capable of regenerating spinal, renal, skeletal muscle and cardiac nervous tissue (Okamura et al., 2023), they show spontaneous degeneration of the islets of Langerhans and are prone to hyperglycaemia, obesity and diabetes without insulin resistance (Maden & Varholick, 2020). This aspect requires interpretation in terms of its possible meaning in the process of physiological adaptation.…”

Section: Introductionmentioning

confidence: 99%

Homeostasis and evolution in relation to regeneration and repair

Cano‐Martínez,

Rubio‐Ruiz,

Guarner‐Lans

2024

The Journal of Physiology

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Homeostasis constitutes a key concept in physiology and refers to self‐regulating processes that maintain internal stability when adjusting to changing external conditions. It diminishes internal entropy constituting a driving force behind evolution. Natural selection might act on homeostatic regulatory mechanisms and control mechanisms including homeodynamics, allostasis, hormesis and homeorhesis, where different stable stationary states are reached. Regeneration is under homeostatic control through hormesis. Damage to tissues initiates a response to restore the impaired equilibrium caused by mild stress using cell proliferation, cell differentiation and cell death to recover structure and function. Repair is a homeorhetic change leading to a new stable stationary state with decreased functionality and fibrotic scarring without reconstruction of the 3‐D pattern. Mechanisms determining entrance of the tissue or organ to regeneration or repair include the balance between innate and adaptive immune cells in relation to cell plasticity and stromal stem cell responses, and redox balance. The regenerative and reparative capacities vary in different species, distinct tissues and organs, and at different stages of development including ageing. Many cell signals and pathways play crucial roles determining regeneration or repair by regulating protein synthesis, cellular growth, inflammation, proliferation, autophagy, lysosomal function, metabolism and metalloproteinase cell signalling. Attempts to favour the entrance of damaged tissues to regeneration in those with low proliferative rates have been made; however, there are evolutionary constraint mechanisms leading to poor proliferation of stem cells in unfavourable environments or tumour development. More research is required to better understand the regulatory processes of these mechanisms. image

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Lessons learned from comparative and extreme physiology

Somlyo

2023

J Muscle Res Cell Motil

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Mammalian organ regeneration in spiny mice

Cited by 3 publications

References 131 publications

Advances in Biotechnology for Cellular and Tissue Regeneration: Challenges and Perspectives in Human Disease Treatment

Advances in Biotechnology for Cellular and Tissue Regeneration: Challenges and Perspectives in Human Disease Treatment

Homeostasis and evolution in relation to regeneration and repair

Lessons learned from comparative and extreme physiology

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