Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae

Abstract

Graphical Abstract Highlights d We designed ocular injectable photoreceptor-binding upconversion nanoparticles d The nanoparticles are safe and enable NIR light sensation and pattern vision d This NIR pattern vision is compatible with native daylight vision d This method offers options for mammalian vision repair and enhancement SUMMARY Mammals cannot see light over 700 nm in wavelength. This limitation is due to the physical thermodynamic properties of the photon-detecting opsins. However, the detection of naturally invisible nearinfrared (NIR) light is a desirable ability. To break this limitation, we developed ocular injectable photoreceptor-binding upconversion nanoparticles (pbUCNPs). These nanoparticles anchored on retinal photoreceptors as miniature NIR light transducers to create NIR light image vision with negligible side effects. Based on single-photoreceptor recordings, electroretinograms, cortical recordings, and visual behavioral tests, we demonstrated that mice with these nanoantennae could not only perceive NIR light, but also see NIR light patterns. Excitingly, the injected mice were also able to differentiate sophisticated NIR shape patterns. Moreover, the NIR light pattern vision was ambient-daylight compatible and existed in parallel with native daylight vision. This new method will provide unmatched opportunities for a wide variety of emerging bio-integrated nanodevice designs and applications. Continued REAGENT or RESOURCE SOURCE IDENTIFIER Other 65 RN 5uL SYR W/O NEEDLE Hamilton, Switzerland Cat# 7633-01 RN Needle (34/8 mm/3)

Nanobiohybrids: Materials approaches for bioaugmentation

“…Recently, the same group reported another nanobiohybrid with an intricate protocol by building modular skeletal muscle actuators with 3D printing (113), which could (111). (C) Schematic illustration of the injectable photoreceptor-binding upconversion nanoparticles (UCNPs) in mouse (114). (D) Schematic illustration of nanoparticles in a leaf and an image of the light-emitting plants (13).…”

“…(F) Comparison of natural and artificial leaves from their structures and functions (116). Reproduced with permissions from Wiley-VCH (79,115,116), Springer Nature (111), Elsevier (114), and American Chemical Society (13).…”

“…Insects such as mosquitoes, bed bugs, and some beetle species can use portions of the infrared spectrum for vision; however, it is outside mammals' visible spectrum. In Xue and co-workers' report (114), a mouse could gain NIR vision by interfacing the eyeballs of a mouse with upconversion nanoparticles (UCNPs). The synthesized and surface-functionalized NaYF 4 :20%Yb,2%Er@-NaYF 4 core/shell photoreceptor-binding UCNPs act as miniature energy transducers that can transform NIR light into short wavelength visible emissions without the need of further energy input.…”

Biological Considerations of Optical Interfaces for Neuromodulation

“…A schematic diagram of nanoparticle‐enhanced optical stimulation is shown in Figure C. Commonly used nanomaterials for enhanced optical stimulation include gold nanorods, quantum dots, and upconverting nanoparticles . Gold nanorods offer the potential to enhance techniques such as INS by absorbing irradiated energy and increasing the localization of optical stimuli .…”

Nanotribological Performance Factors for Aqueous Suspensions of Oxide Nanoparticles and Their Relation to Macroscale Lubricity

“…Given that some nanoparticle suspensions are lubricious in some applications while others are detrimental, the fundamental mechanisms associated with the presence of NP that give rise to macroscale tribological performance is now the major focus of current research [5,7,9]. The results of such studies also have impact on the broader field of ceramic nanoparticles applications in the fields of physics, materials, chemistry, biomedicine, and pharmaceuticals, where knowledge of the interactions of nanoparticles at solid-liquid interfaces is key to progress [10][11][12][13][14][15].…”