“…Other DNA repair proteins have been shown to affect mitochondrial DNA maintenance in mammalian cells, including the BER flap endonuclease FEN1 (Liu et al, 2008), DNA doublestrand break repair proteins, Rad51p (Sage et al, 2010), Mre11 (Dmitrieva et al, 2011) and Ku80 (Coffey et al, 1999), and the nucleotide excision repair protein CSA (Kamenisch et al, 2010). In addition, in yeast, DNA damage tolerance pathways that utilize the translesion polymerase complexes encoded by Rev1p, Rev3p, and Rev7p also impact mitochondrial mutagenesis (Kalifa and Sia, 2007;Zhang et al, 2006).…”