“…Converging evidence indicates that Trib3 is a pseudokinase with scaffold-like regulatory functions for a number of signaling pathways (Hegedus et al, 2006(Hegedus et al, , 2007. Trib3 is induced by a wide variety of stresses with potential relevance to PD pathophysiology, including metabolic stress (Du et al, 2003;Bi et al, 2008;Carraro et al, 2010;Liu et al, 2010), endoplasmic reticulum stress (Corcoran et al, 2005;Ord and Ord, 2005;Salazar et al, 2009;Zou et al, 2009), oxidative stress (Lange et al, 2008), mitochondrial stress (Ishikawa et al, 2009), and neurotrophic factor deprivation (Mayumi-Matsuda et al, 1999;Kristiansen et al, 2011;Zareen et al, 2013). Both proapoptotic Shang et al, 2009) and antiapoptotic Zhou et al, 2013) actions have been attributed to Trib3.…”