Mammalian cystatin and protagonists in brain diseases

Amin, Fakhra; Khan, Mohd Shahnawaz; Bano, Bilqees

doi:10.1080/07391102.2019.1620636

Cited by 16 publications

(17 citation statements)

References 270 publications

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“…Once these residues insert into the active-site groove of the protease, they block access to substrate proteins; the shape of this wedge is complementary to that of the groove, which contributes to the tight binding. Two cystatin molecules can also do ‘domain swapping’ resulting in higher stability or for some vertebrate cystatins allows their oligomerization (Amin et al ., 2020).…”

Section: Molecular and Genetic Aspects Of A Lumbricoides Cystatinsmentioning

confidence: 99%

Helminth-derived cystatins: the immunomodulatory properties of an Ascaris lumbricoides cystatin

2021

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Section: Molecular and Genetic Aspects Of A Lumbricoides Cystatinsmentioning

confidence: 99%

Helminth-derived cystatins: the immunomodulatory properties of an Ascaris lumbricoides cystatin

2021

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“…Several studies showed that Cys C is a target for intervention in neurological diseases, as its expression increased with animal models of human neurological disorders [9,42]. However, in future research, whether targeted therapy can be conducted and the mechanisms of Cys C on PD are challenging research topics.…”

Section: Discussionmentioning

confidence: 99%

On the correlation between serum Cystatin C and Parkinson’s disease in the Chinese population: a promising biomarker?

Yang¹,

Cai²,

Liu³

et al. 2021

Journal of Integrative Neuroscience

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As there is no clear biomarker to diagnose Parkinson's disease, this meta-analysis aims to comprehensively evaluates the correlation between serum Cystatin C levels and Parkinson's disease in the Chinese population by the meta-analysis method. PubMed, Web of Science, Embase, Cochrane Library, China national knowledge infrastructure, and China WanFang databases were systematically searched on the correlation between serum Cystatin C and Parkinson's disease. The results showed that Cystatin C level in Parkinson's disease patients compared with the control group, the standardized mean difference = 1.78 (95% CI: 1.33~2.24, P < 0.05). The level of Cystatin C in the late Parkinson's disease stage compared with that in the mid-term of Parkinson's disease, the standardized mean difference was = 0.78 (95% CI: 0.08~1.49, P < 0.05). The Cystatin C level in the mid-term of Parkinson's disease compared with that in the early Parkinson's disease stage, the standardized mean difference was 1.24 (95% CI: 0.35~2.12, P < 0.05). The level of Cystatin C in Parkinson's disease with mild cognitive impairment compared with Parkinson's disease without mild cognitive impairment, the standardized mean difference was 1.29 (95% CI: 0.47~2.10, P < 0.05). The differences were all statistically significant. In conclusion, a high level of serum Cystatin C may be involved in the occurrence and development of Parkinson's disease, whose level is higher in Parkinson's disease patients with mild cognitive impairment than that in Parkinson's disease without mild cognitive impairment. Therefore, Cystatin C in serum is a promising biomarker for diagnosing Parkinson's disease.

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“…Their relatively high concentration is found in chicken egg white. These types of cystatins are: C, D, S, SN, SA, E, F, and M. [22,23].…”

Section: Four Families Of Cystatinsmentioning

confidence: 99%

“…Serum levels of cystatin C are much more constant than creatinine levels, the best-known marker of glomerular fi ltration rate. The plasma level of cystatin C only rises as renal function fails [36,76]. Newman et al [77] reported an assay using cystatin C that showed to be more sensitive as a screening test for early renal damage than creatinine.…”

Section: Cystatins As Disease Biomarkersmentioning

confidence: 99%

Egg White Cystatin – A Review

et al. 2020

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Hen eggs are widely used, not only for human consumption, but also as an important material in food production and in pharmaceutical and cosmetics industry. Cystatin is a biologically active component of egg white, mostly used as an inhibitor of papain-like cysteine proteases. It was isolated from chicken egg white and has later been used in the nomenclature of structurally and functionally related proteins. Cystatins from animals, including mouse, rat, dog, cow and chicken egg white have been isolated and recently used in foodstuffs and drug administration. Cystatin has found its place and use in medicine due to its antimicrobial, antiviral and insecticidal effects, for the prevention of cerebral hemorrhage and control of cancer cell metastasis.

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Mammalian cystatin and protagonists in brain diseases

Cited by 16 publications

References 270 publications

Helminth-derived cystatins: the immunomodulatory properties of an Ascaris lumbricoides cystatin

Helminth-derived cystatins: the immunomodulatory properties of an Ascaris lumbricoides cystatin

On the correlation between serum Cystatin C and Parkinson’s disease in the Chinese population: a promising biomarker?

Egg White Cystatin – A Review

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