Mammaglobin B may be a prognostic biomarker of uterine corpus endometrial cancer

Abstract

Mammaglobin B, also referred to as secretoglobin family 2A member 1 (SCGB2A1), has been reported to be highly expressed in uterine corpus endometrial cancer (UCEC) compared with in the normal endometrium. However, the prognostic value of SCGB2A1 in UCEC remains unclear. The Oncomine, The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium databases were used to explore the differential expression of SCGB2A1. Furthermore, data of patients with UCEC were downloaded from TCGA, and logistic regression analysis, survival analysis, univariate and multivariate analyses, and nomogram construction were performed to identify its prognostic value in UCEC. Additionally, gene set enrichment analysis (GSEA) was utilized to estimate the mechanisms of SCGB2A1 in UCEC. Finally, immune infiltration of SCGB2A1 in UCEC was analyzed using the Tumor Immune Estimation Resource. Decreased mRNA and protein expression levels of SCGB2A1 were significantly associated with poor prognostic clinicopathological characteristics (all P<0.05). Additionally, low expression levels of SCGB2A1 were associated with decreased survival of patients with UCEC compared with high expression levels of SCGB2A1. Furthermore, the independent prognostic value of SCGB2A1 in UCEC was identified by univariate and multivariate analyses. A nomogram based on 6 variables, including SCGB2A1 expression, was developed for the estimation of the 1-, 3-, and 5-year survival probability in UCEC. Additionally, GSEA suggested that the vascular endothelial growth factor, PTEN, platelet-derived growth factor, DNA repair, KRAS signaling, and PI3K-AKT-mTOR signaling pathways were differentially enriched in the low SCGB2A1 expression phenotype. Finally, high infiltration levels of CD8 + T cells were associated with SCGB2A1 in UCEC and this was associated with prognosis. The present results indicated that SCGB2A1 may be a promising independent prognostic factor in UCEC. These signaling pathways may be crucial for the regulation of UCEC via SCGB2A1.

Shotgun Proteomics for the Identification and Profiling of the Tear Proteome of Keratoconus Patients

“…A role in maintaining the inflammatory state in cancerous tissues has been postulated for ZG16B, 62 and mammaglobin-B has been proposed as a prognostic biomarker of uterine endometrial cancer. 63 At the tear level, the overexpression of ZG16B has been found in patients with dry eye, 39 and previous studies have suggested the possible involvement of mammaglobin-B in the lipid tear film structure. Moreover, the dysregulation of mammaglobin-B was previously described in the KC tear samples.…”

A radiogenomics application for prognostic profiling of endometrial cancer

“…The third upregulated gene in the signature was the transcriptional factor GATA3, a pioneer transcription factor yet to be functionally described in EC, but that has been linked to the regulation of estrogen signaling in breast cancer 36 . Eight genes in the signature had reduced expression in the aggressive cancers, and decreased expression of SCGB2A1 is known to be associated with poor survival in EC 37 , 38 . The remaining genes are less characterized in EC tumors but have interesting roles in other cancers related to transcriptional regulation (PBX1 interacts with the estrogen-axis in breast cancer 39 and SAT1 functions as a transcriptional regulator in aggressive brain tumors 40 ), and key signaling pathways including the transforming growth factor β (TGFβ) pathway (GDF15 41 ), the PI3K/AKT-pathway (ANX1A 42 ), and the Mitogen-activated protein kinase (MAPK) pathway (CNDP2 43 ).…”

ALDH2 promotes uterine corpus endometrial carcinoma proliferation and construction of clinical survival prognostic model

“…Several research results have shown that bioinformatics is a reliable research tool. In gastric cancer, GDF-15 can be used as a biomarker for gastric cancer [ 32 ]; In liver cancer, YTHDF1 expression is elevated in liver cancer patients [ 33 ]; In UCEC, Li found that Mammaglobin B is a prognostic marker of UCEC [ 34 ]. Similarly, we downloaded the expression data of 33 cancers in TCGA.…”