Maltodextrin-α-tocopherol conjugates of vitamin E: Influence of degree of derivatization on physicochemical properties and biological evaluation

Helal, Hala Mahmoud; Samy, Wael; El‐Fakharany, Esmail M.; Kamoun, Elbadawy A.; Mortada, Sana Mohamed; Sallam, Marwa A.

doi:10.1016/j.jddst.2020.102097

Cited by 10 publications

(25 citation statements)

References 38 publications

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“…In addition, peaks of vitamin E appeared at ѵ 1435 and 1390 cm −1 for -CH3 asymmetric/symmetric peaks, at ν 1226 cm −1 of C-O stretching of phenol and 2924 cm −1 of C-H stretching along with ester bond specific peak at ν 1742 cm −1 . 12 Moreover, TAC which has an empirical formula of C 44 H 69 NO 12 showed characteristic peaks at ν 3457, 1727, 1639, 1184 and 1098 cm −1 , corresponding to O-H stretching vibration, C=O (ester and ketone) stretching vibrations, C=O (amide) and C=C 32 Overall, FTIR spectra of TAC@MD-α-TOC micelles revealed that all the characteristic peaks of TAC and the polymer were in their original places without addition or deletion, indicating absence of strong chemical interaction with no incompatibility among all the formulation ingredients.…”

Section: Dsc Thermographs and Ftir Spectra Of Polymeric Nano-micellesmentioning

confidence: 99%

“…This gives an indication that upon in vivo administration and dilution with physiological fluids, micellar structures integrity of the biopolymer will be maintained, thus overcoming the instability problems encountered with conventional micelles from detergent-like polymers. 12,17 In vitro and in vivo Toxicological Assessment TAC has serious toxicological dose-dependent hazards such as hyperglycemia, hyperkalemia, vaso-constrictive properties, decrease in neutrophil counts and more seriously nephrotoxicity. 38 Thus, preventing TAC accompanied side effects without decreasing its dose to obtain the desired therapeutic outcomes is one of the basic aims for utilizing MD-α-TOC based polymeric micelles as TAC nanocarriers.…”

Section: In Vitro Stability Of Prepared Md-α-toc Nano-micellesmentioning

confidence: 99%

“…CMCs values of synthesized conjugates shown in Table 2, seemed to be obviously very low which might enhance the stability of prepared nanomicellar structures upon dilution with physiological fluids, thus overcoming the main obstacle facing nano-micelles as drug delivery systems. 12 Preparation and Characterization of TAC-Loaded MD-α-TOC Nano-Micelles PS, Zeta Potential, PDI, EE and DL Direct dialysis method was chosen over other techniques for preparation of nano-micelles, as shown in Figure 1B. This method granted an efficient dispersion of the drug during the micelle formation as both TAC and polymer were dissolved in DMSO.…”

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confidence: 99%

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Potential Privilege of Maltodextrin-α-Tocopherol Nano-Micelles in Seizing Tacrolimus Renal Toxicity, Managing Rheumatoid Arthritis and Accelerating Bone Regeneration

Helal¹,

Samy²,

Kamoun³

et al. 2021

IJN

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Background: Tacrolimus (TAC) is a powerful immunosuppressive agent whose therapeutic applicability is confined owing to its systemic side effects. Objective: Herein, we harnessed a natural polymer based bioconjugate composed of maltodextrin and α-tocopherol (MD-α-TOC) to encapsulate TAC as an attempt to overcome its biological limitations while enhancing its therapeutic anti-rheumatic efficacy. Methods: The designed TAC loaded maltodextrin-α-tocopherol nano-micelles (TAC@MDα-TOC) were assessed for their physical properties, safety, toxicological behavior, their ability to combat arthritis and assist bone/cartilage formation. Results: In vitro cell viability assay revealed enhanced safety profile of optimized TAC@MD-α-TOC with 1.6-to 2-fold increase in Vero cells viability compared with free TAC. Subacute toxicity study demonstrated a diminished nephro-and hepato-toxicity accompanied with optimized TAC@MD-α-TOC. TAC@MD-α-TOC also showed significantly enhanced anti-arthritic activity compared with free TAC, as reflected by improved clinical scores and decreased IL-6 and TNF-α levels in serum and synovial fluids. Unique bone formation criteria were proved with TAC@MD-α-TOC by elevated serum and synovial fluid levels of osteocalcin and osteopontin mRNA and proteins expression. Chondrogenic differentiation abilities of TAC@MD-α-TOC were proved by increased serum and synovial fluid levels of SOX9 mRNA and protein expression. Conclusion: Overall, our designed bioconjugate micelles offered an excellent approach for improved TAC safety profile with enhanced anti-arthritic activity and unique bone formation characteristics.

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Section: Dsc Thermographs and Ftir Spectra Of Polymeric Nano-micellesmentioning

confidence: 99%

Section: In Vitro Stability Of Prepared Md-α-toc Nano-micellesmentioning

confidence: 99%

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confidence: 99%

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Potential Privilege of Maltodextrin-α-Tocopherol Nano-Micelles in Seizing Tacrolimus Renal Toxicity, Managing Rheumatoid Arthritis and Accelerating Bone Regeneration

Helal¹,

Samy²,

Kamoun³

et al. 2021

IJN

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“…Maltodextrin (MD) is a reducing hydrophilic polysaccharide that has been used extensively in food industry, beverage products and pharmaceutical industry ( Figure 1) [5,6]. It Maltodextrins ((C6H10O5)n) are non-sweet saccharide polymers that consist of D-glucose units linked primarily by α (1,4)-glycosidic bonds and have a dextrose equivalent (DE) of less than 20 [7].…”

Section: Introductionmentioning

confidence: 99%

“…Maltodextrins and starches are some of the carbohydrates most commonly employed as vehicles for the microencapsulation of bioactive compounds [9]. Chemically, maltodextrin has different reaction sites in repeating glucose moieties providing wide alternatives in chemical conjugation process [5].…”

Section: Introductionmentioning

confidence: 99%

One-Pot Selective Functionalization of Polysaccharides with Urea

Guntero

Peralta

Noriega

et al. 2020

The 24th International Electronic Conference on Synthetic Organic Chemistry

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Natural Polysaccharides are polymers composed of monosaccharide units bound together by glycosidic linkages. In their native form, these polymers may not be able to provide all the desired properties for a particular application. Thus, the functionalization of its reactive hydroxyl groups would change their surface properties. In this work, we evaluated the derivatization of OH groups of maltodextrin polysaccharide with urea. By a one-pot selective procedure carried out at room temperature for 3 h, urea united at maltodextrin through covalent bonding was obtained. The results showed that after functionalization with urea, the pH and solubility in polar solvents of the new material increased. Derivatization of maltodextrin with urea confers stability, and terminal amide groups on the surface of this material represent a versatile reactive functional group for conjugation with other molecules for potential applications in the development of new materials.

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Delivery strategies of amphotericin B for invasive fungal infections

Wang

Mohammad

Fan

et al. 2021

Acta Pharmaceutica Sinica B

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Invasive fungal infections (IFIs) represent a growing public concern for clinicians to manage in many medical settings, with substantial associated morbidities and mortalities. Among many current therapeutic options for the treatment of IFIs, amphotericin B (AmB) is the most frequently used drug. AmB is considered as a first-line drug in the clinic that has strong antifungal activity and less resistance. In this review, we summarized the most promising research efforts on nanocarriers for AmB delivery and highlighted their efficacy and safety for treating IFIs. We have also discussed the mechanism of actions of AmB, rationale for treating IFIs, and recent advances in formulating AmB for clinical use. Finally, this review discusses some practical considerations and provides recommendations for future studies in applying AmB for combating IFIs.

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Maltodextrin-α-tocopherol conjugates of vitamin E: Influence of degree of derivatization on physicochemical properties and biological evaluation

Cited by 10 publications

References 38 publications

Potential Privilege of Maltodextrin-α-Tocopherol Nano-Micelles in Seizing Tacrolimus Renal Toxicity, Managing Rheumatoid Arthritis and Accelerating Bone Regeneration

Potential Privilege of Maltodextrin-α-Tocopherol Nano-Micelles in Seizing Tacrolimus Renal Toxicity, Managing Rheumatoid Arthritis and Accelerating Bone Regeneration

One-Pot Selective Functionalization of Polysaccharides with Urea

Delivery strategies of amphotericin B for invasive fungal infections

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