MALT lymphoma at the base of tongue of a 29-year-old woman treated with radiation therapy alone

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is frequently reported in the gastrointestinal tract (GIT), but the incidence is low in the upper aerodigestive tract. In particular, MALT lymphoma of the tongue is very rare. Only four cases have been reported in the English literature to date. We report a case of 29-year-old woman who had a past history of peripheral T cell lymphoma of the head and neck and a new mass at the right base of tongue 3 years later. An incisional biopsy of the base of tongue revealed a new pathology, one that of extranodal marginal zone B cell lymphoma (MALT lymphoma). After staging work-up, she was diagnosed to be at the Ann Arbor stage IE. She was treated with 30.6 Gy of radiation therapy alone and there was no recurrence after 3 years follow-up.

Valproic Acid Inhibits Peripheral T Cell Lymphoma Cells Behaviors via Restraining PI3K/AKT Pathway

“…Peripheral T cell lymphoma (PTCL) is a type of heterogeneous lymphoproliferative diseases that a ect multiorgan including the digestive system. When PTCLs occur in the digestive system, dysphagia, digestive tract stenosis, and other type of symptoms like Crohn's disease could occur [9][10][11]. Clarifying the pathogenic mechanism of PTCLs is important to the development of e ective therapeutic methods.…”

“…As PTCL has diverse clinical symptoms, PTCL could a ect upper digestive tract to induce esophageal stricture and dysphagia [9]. Tongue could also be the target tissue of lymphoma [10].…”