Malondialdehyde (MDA) and protein carbonyl (PCO) levels as biomarkers of oxidative stress in subjects with familial hypercholesterolemia

Pirinççioğlu, Ayfer Gözü; Gökalp, Deniz; Pirinççioğlu, Mihdiye; Kızıl, Göksel; Kızıl, Murat

doi:10.1016/j.clinbiochem.2010.07.022

Cited by 189 publications

(113 citation statements)

References 36 publications

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“…Carbonyl groups are introduced into proteins by various oxidative pathways. ROS can react directly with the proteins, or they can react with molecules such as sugars and lipids, generating products (reactive carbonyl species) that may react with proteins and lead to the formation of protein carbonyl derivatives [2,3,4,5,6,7]. …”

Section: Introductionmentioning

confidence: 99%

Oxidative Protein Damage with Carbonyl Levels and Nitrotyrosine Expression after Chemotherapy in Bone Marrow Transplantation Patients

Sabuncuoğlu¹,

Öztaş²,

Çetinkaya

et al. 2012

Pharmacology

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Protein oxidation is defined as the covalent modification of a protein, induced either directly by reactive oxygen species/reactive nitrogen species or indirectly by reaction with secondary by-products of oxidative stress. Protein carbonyls are the most commonly measured products of protein oxidation. Additionally, nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide. Samples were collected before the preparative regimen (10 days before transplantation; day –10), on transplantation day (day 0), and after transplantation (days 7, 14, and 28) from 16 pediatric allogeneic hematopoietic stem cell transplantation (HSCT) patients. The erythrocyte 3-nitrotyrosine expression was shown to be significantly increased after chemotherapy. In accordance, the mean plasma carbonyl levels on days 14 and 28 were significantly higher than on the other days. High-dose chemotherapy applied in the preparative regimen of HSCT may be responsible for this long-term oxidation of plasma proteins. These results show that high-dose chemotherapy resulted in protein oxidation both in plasma and in erythrocytes in HSCT patients.

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Section: Introductionmentioning

confidence: 99%

Oxidative Protein Damage with Carbonyl Levels and Nitrotyrosine Expression after Chemotherapy in Bone Marrow Transplantation Patients

Sabuncuoğlu¹,

Öztaş²,

Çetinkaya

et al. 2012

Pharmacology

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show abstract

“…disease, obesity, type II diabetes, neurodegenerative disease, atherosclerosis, asthma, chronic obstructive pulmonary disease, and cancer (15)(16)(17)(18)(19)(20)(21)(22)(23). Notwithstanding, a wide variety of other reactive lipid aldehyde species are formed at appreciable levels in mammalian cells, though the specific effect of these lipids on cellular metabolism is less defined.…”

mentioning

confidence: 99%

Oxidative stress and lipotoxicity

Hauck

Bernlohr

2016

Journal of Lipid Research

234

175

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“…Damaged protein accumulates in photodamaged skin, and protein carbonylation is a biomarker of oxidative stress-induced protein damage [11]. The protein carbonyl content in HaCaT cells exposed to UVB (13 nmol/mg) was significantly elevated relative to untreated control and PAEpretreated cells; however, this value decreased to 11 nmol/mg in cells pretreated with PAE prior to UVB exposure (Fig 3B).…”

Section: Effect Of Pae On Uvb-induced Oxidative Lipid Protein and Dmentioning

confidence: 71%

Photoprotective Effect of a <i>Polyopes affinis</i> (Harvey) Kawaguchi and Wang (<i>Halymeniaceae</i>)-Derived Ethanol Extract on Human Keratinocytes

Hyun¹,

Piao²,

Kc³

et al. 2014

Trop. J. Pharm Res

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Malondialdehyde (MDA) and protein carbonyl (PCO) levels as biomarkers of oxidative stress in subjects with familial hypercholesterolemia

Cited by 189 publications

References 36 publications

Oxidative Protein Damage with Carbonyl Levels and Nitrotyrosine Expression after Chemotherapy in Bone Marrow Transplantation Patients

Oxidative Protein Damage with Carbonyl Levels and Nitrotyrosine Expression after Chemotherapy in Bone Marrow Transplantation Patients

Oxidative stress and lipotoxicity

Photoprotective Effect of a <i>Polyopes affinis</i> (Harvey) Kawaguchi and Wang (<i>Halymeniaceae</i>)-Derived Ethanol Extract on Human Keratinocytes

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