Malondialdehyde as a Useful Biomarker of Low Hand Grip Strength in Community-Dwelling Stroke Patients

Abstract

The assessment of muscle strength by hand grip strength (HGS) is used to evaluate muscle weakness and wasting among stroke patients. This study aimed to investigate the association of oxidative stress/oxidative damage and inflammatory biomarkers with muscle strength and wasting, as evaluated by HGS, among community-dwelling post-stroke patients. The HGS of both paretic and non-paretic limbs was negatively associated with modified Rankin scale (mRS) values. The serum levels of catalase activity and malondialdehyde (MDA), and plasma tumor necrosis factor (TNF)-α levels were significantly increased in post-stroke patients compared with non-stroke controls. Further analysis highlighted that hydrogen peroxide was positively correlated with HGS in the paretic limbs. Interestingly, an elevated MDA level, excluding advanced age and high mRS, increased the risk of low HGS in the non-paretic limbs of stroke patients. This study suggests that there is a detrimental association between MDA and muscle strength and early muscle wasting among post-stroke patients. Hence, MDA is a potentially useful biomarker of muscle weakness and wasting in post-stroke patients living in the community.

Comparison the Impact on TENS and Conventional Physiotherapy in Stroke Patients with Upper Limb Dysfunctions: A Research Protocol

“…This frequently encountered condition has a tremendous impact on a person's experience, including physiological, emotional, and social impacts [6]. The far more serious condition following a stroke is hemiparesis, which is followed by aphasia, visual problems, facial paralysis, stiffness, instability, post-stroke discomfort or bodily irritability, & swallowing [7].…”

“…Upper extremity paresis, which is marked by muscular weakness in the afflicted limb over one side of the body, is among the most prevalent instances (up to 85 percent of stroke survivors) [6]. These symptoms have a huge impact on stroke victims' everyday lives as well as their quality of life [7]. Differences in the size and power of skeletal muscles across both paretic and non-paretic limbs have been seen in poststroke subjects [7].…”

“…These symptoms have a huge impact on stroke victims' everyday lives as well as their quality of life [7]. Differences in the size and power of skeletal muscles across both paretic and non-paretic limbs have been seen in poststroke subjects [7]. The number of extra motor units recorded in the hypothenar muscles of paretic limbs reduces gradually as soon as four to thirty hours following the onset of an acute ischemic stroke (IS) compared to non-paretic limbs [7].…”

Association of Plasma Carotenoid and Malondialdehyde Levels with Physical Performance in Korean Adolescents

“…A number of clinical [6,7] and epidemiological [8,9] studies have evaluated the degree of oxidative stress/oxidative damage by measuring MDA contents in humans. A recent study indicated that an elevated MDA level was associated with a higher risk of low hand grip strength in the non-paretic limbs of stroke patients [10].…”

“…A number of clinical [6,7] and epidemiological [8,9] studies have evaluated the degree of oxidative stress/oxidative damage by measuring MDA contents in humans. A recent study indicated that an elevated MDA level was associated with a higher risk of low hand grip strength in the non-paretic limbs of stroke patients [10].Carotenoids are natural pigments responsible for the yellow, orange, and red colors of various fruits and vegetables [11]. Human organisms cannot synthesize carotenoids; therefore, these compounds must be supplied with the diet.…”