Malondialdehyde and CA II autoantibody levels are elevated in children with undescended testes

Alver, Ahmet; İmamoğlu, Mustafa; Menteşe, Ahmet; Şentürk, Ayşe; Bülbül, Serap Samut; Kahraman, Cemil; Sümer, Ayşegül

doi:10.1007/s00345-013-1129-9

Cited by 6 publications

(5 citation statements)

References 29 publications

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“…Many studies reported that the MDA levels in UDT group were significantly higher than that of the healthy control group. 2,5 Our results showed that lipid peroxidation increased in children with UDT. With the prolonged temperature exposure time of the testicle, the oxidative damage can increase.…”

Section: Discussionmentioning

confidence: 52%

“…They also stated that testicular torsion is an acute condition, but UDT is a chronic condition. 2 In one study, the rat testicle was torsioned and the two groups were formed as 2 and 4 hours after torsion. The IMA level in the group 4 hours after torsion was significantly higher than sham group and the group 2 hours after torsion.…”

Section: Discussionmentioning

confidence: 99%

“…1 UDT is one of the most common newborn anomalies and has a high incidence especially in premature and low-birth-weight infants. 2 The main purpose of the treatment is to reduce the risk of sub-/infertility and maintain fertility. 3 Previous studies have reported that the surgical approach is the most appropriate treatment choice for UDT.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative DNA Damage and NOX4 Levels in Children with Undescended Testes

2019

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Background Undescended testis (UDT) is a common urological disorder. Patients with UDT have a risk of malignancy and infertility. The development of these conditions may be due to oxidative stress mediated by reactive oxygen species. The aim of this study was to investigate the relationship between these parameters by detecting oxidative DNA damage (8-hydroxy 2 deoxyguanosine/106 deoxyguanosine), ischemia-modified albumin (IMA), malondialdehyde (MDA), and nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) levels in children with UDT and healthy control group. Materials and Methods The blood samples were obtained from 30 patients with UDT and 40 healthy male subjects. The levels of oxidative DNA damage were detected by high-pressure liquid chromatography method. We used commercially available kits that use enzyme-linked immunosorbent assay method to measure IMA, MDA, and NOX4 levels. Results The levels of MDA, IMA, NOX4, and oxidative DNA damage in children with UDT were statistically significantly higher than control group. In addition, we found that the levels of NOX4, IMA, and oxidative DNA damage after 12 months of age was significantly higher than before 12 months of age. Conclusion We identified increased lipid peroxidation, oxidative DNA damage, IMA, and NOX4 levels in children with UDT. Delay in the treatment of UDT may cause oxidative damage. That is why, according to us the antioxidant treatment may be beneficial in children with UDT.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

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Oxidative DNA Damage and NOX4 Levels in Children with Undescended Testes

2019

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“…The MDA levels in erythrocytes were determined as described in a previous publication (Agilent 1100 series HPLC systems, Waldbronn, Germany), C18 column was used for measurements (ZORBAX Eclipse XDB-C18; 4.6 x 150mm; Agilent Technologies, Santa Clara, CA, USA) [12]. Detection was performed fluorometrically (excitation 536 nm and emission 555 nm).…”

Section: Determination Of Malondialdehyde (Mda) Levels In Erythrocytesmentioning

confidence: 99%

Serum levels of anti-carbonic anhydrase antibodies and erythrocyte oxidative stress markers in endometriosis

Ural¹,

Alver²,

Efe³

et al. 2020

j-ebr

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To evaluate the serum levels of anti-carbonic anhydrase I-II antibodies and erythrocyte oxidative stress markers in endometriosis. Method: This case-control laboratory investigation was performed in the obstetrics and gynecology department of a tertiary center. Serum anti-carbonic anhydrase I and II antibodies and erythrocyte oxidative stress markers (superoxide dismutase, malondialdehyde, glutathione peroxidase and catalase) were compared with control group (n = 30) in the endometriosis group (n = 33). Correlation between carbonic anhydrase autoantibodies and oxidative stress markers were tested. Results: Serum levels of anti-carbonic anhydrase II antibodies were found to be significantly increased in the endometriosis group compared to controls. The erythrocyte antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase and catalase) and malondialdehyde levels in erythrocytes were increased in endometriosis group; but only glutathione peroxidase activity and malondialdehyde levels were significantly higher in endometriosis group. No correlation was detected between anti-carbonic anhydrase antibodies and oxidative stress markers. Conclusions: Our results indicate that erythrocyte oxidative stress and anti-carbonic anhydrase antibodies may be involved in the pathophysiology of endometriosis.

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“…Similar publications in the literature did not support this issue with postoperative period values. 2,3 Due to lack of cases, budget, and time limitations, the aforementioned deficiencies may not have been covered; therefore, this issue should be addressed by further studies and samples of testicular tissue itself rather than only blood samples.…”

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confidence: 99%

Comment: Oxidative DNA Damage and NOX4 Levels in Children with Undescended Testes

2020

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Malondialdehyde and CA II autoantibody levels are elevated in children with undescended testes

Abstract: MDA is the most reliable and decisive biochemical marker displaying oxidative damage in undescended testes, and an autoimmune response may be triggered by oxidative stress against CA II during the UDT process.

Cited by 6 publications

References 29 publications

Oxidative DNA Damage and NOX4 Levels in Children with Undescended Testes

Oxidative DNA Damage and NOX4 Levels in Children with Undescended Testes

Serum levels of anti-carbonic anhydrase antibodies and erythrocyte oxidative stress markers in endometriosis

Comment: Oxidative DNA Damage and NOX4 Levels in Children with Undescended Testes

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