Malocclusion in individuals with osteogenesis imperfecta: A systematic review and meta‐analysis

Abstract

Objective: To evaluate whether individuals with osteogenesis imperfecta (OI) are more affected by malocclusion than individuals without OI. Materials and Methods: Searches in PubMed, Ovid, Web of Science, Scopus, Lilacs and gray literature were performed. Data extraction was conducted by two researchers. Risk of bias assessment employing the Newcastle-Ottawa Scale and meta-analysis were conducted. Results were provided with mean difference (MD), odds ratio (OR) and 95% confidence interval (CI). Strength of evidence was determined. Results: Six cross-sectional studies were included. In comparison with individuals without OI, the group with OI had 19.69-fold greater chance of exhibiting Angle Class III malocclusion (OR = 19.69, CI: 9.00-43.09) and presenting anterior crossbite greater (MD = 6.08, CI: 2.40-9.77). Individuals without OI had a significantly greater ANB angle (MD = 3.88, CI: 1.15-6.61) and SNA angle (MD = 2.11, CI: 0.24-3.98) in comparison with those with OI. No difference between groups was found for SNB (MD = −0.50, CI: −2.21 to 1.21) and open bite (MD = 0.98, CI: −0.29 to 2.25). Most studies included had moderate methodological quality. Strength of evidence was low or very low. Conclusions: The occurrence of Angle Class III malocclusion and anterior crossbite was greater among individuals with OI compared to those without OI. These findings can assist stakeholders about the occlusal abnormalities affecting OI individuals.

The patient clinical journey and socioeconomic impact of osteogenesis imperfecta: a systematic scoping review

“…Existing reviews of OI literature do not provide a systematic overview of the scope of published records, but rather follow a narrative design [ 61 – 63 ], or aim to answer specific research questions [ 9 , 11 , 18 – 21 , 64 – 72 ]. Therefore, the aim of this review was to determine the breadth of literature available and provide a snapshot of the evidence it covers.…”

Correction of malocclusion in individuals with osteogenesis imperfecta: a systematic review

“…According to previous studies, the prevalence of malocclusion is high among individuals diagnosed with OI and the frequency and severity vary significantly among the different types of the disease (Hidalgo-Perea & Green, 2021;Rizkallah et al, 2013;Retrouvey et al, 2019;Prado et al, 2022). Besides the systemic clinical consequences caused by OI, the high prevalence of malocclusion can affect the functioning of the stomatognathic system in this portion of the population.…”

“…A recent systematic review found that class III malocclusion with anterior crossbite is the more frequently found in individuals with OI compared to individuals without this disease (Prado et al, 2022). The growth of all craniofacial bones is affected by OI due to defects in intramembranous or endochondral ossification.…”

Oral manifestations and rehabilitation of a patient with osteogenesis imperfecta

“…In addition, abnormal bone growth, posture, head size might be contributing factors to the development of malocclusions, which may become more serious with time [20]. Malocclusions can impair everyday activities such as chewing and speaking and consequently have negative impact on quality of life [12,24], which was one of the main concerns of our patient.…”

“…Malocclusions can impair daily activities, such as chewing and speaking, which has negative impact on quality of life and serious psychological and social implications [12]. Also, affected teeth might have crowns with a bulbous structure, constriction in the cementoenamel junction, irregular root morphology, enlarged pulp chamber as well as pulp stones and obliterations [13,14].…”