Malnutrition Is Common in Systemic Sclerosis: Results from the Canadian Scleroderma Research Group Database

Baron, Murray; Hudson, Marie; Steele, Russell

doi:10.3899/jrheum.090694

Cited by 124 publications

(92 citation statements)

References 37 publications

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“…This tool combines body mass index (BMI) and weight loss measures. Using this tool, a study of 586 Canadian SSc patients showed that the risk of malnutrition in SSc was high, with more than 28% of patients being at medium or high risk of malnutrition [43]. Malnutrition was associated with more GI complaints, early disease, diffuse disease, and with possible malabsorption.…”

Section: Malnutrition In Sclerodermamentioning

confidence: 99%

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Gastrointestinal Manifestations of Scleroderma: Recent Progress in Evaluation, Pathogenesis, and Management

2011

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Gastrointestinal (GI) involvement is frequent in scleroderma (systemic sclerosis [SSc]) and is the most frequent internal complication of the disease. Patients with GI involvement have impaired quality of life, and their prognosis may be one of severe impairment. Unfortunately, GI involvement is often noticed when severe complications have already occurred, is irreversible, and is difficult to manage. The past 2 to 3 years have been rich in exciting studies that we hope will help identify, prevent, treat, and monitor disease progression. Recent studies on the pathophysiology of GI tract disease could lead to advances in the treatment of GI tract involvement. The importance of treating gastroesophageal reflux (GER) has been reinforced by studies showing GER damage in almost all SSc patients, and the fact that GER damage is reversible if early treatment with proton pump inhibitors is introduced. Moreover, recent data showing a link between GER and interstitial lung disease in SSc underscore the importance of aggressive GER treatment in SSc patients. A novel lung pattern possibly related to GER also has been described. New, exciting data on gastric vascular antral ectasia have been published. Finally, malnutrition in SSc patients has been highlighted, and anorectal involvement has been emphasized.

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Section: Malnutrition In Sclerodermamentioning

confidence: 99%

“…Malnutrition was associated with more GI complaints, early disease, diffuse disease, and with possible malabsorption. Interestingly, it was also associated with the physician global disease assessment of disease severity, which implies that there may be factors other than the GI tract that can predict malnutrition [43].…”

Section: Malnutrition In Sclerodermamentioning

confidence: 99%

Gastrointestinal Manifestations of Scleroderma: Recent Progress in Evaluation, Pathogenesis, and Management

2011

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“…43 Experts agree that all patients with SSc should be screened for malnutrition. 25 Weight loss is the most sensitive indicator of malnutrition and should be performed at regular intervals.…”

Section: Malnutritionmentioning

confidence: 99%

Systemic Sclerosis

Gyger

Baron

2015

Rheumatic Disease Clinics of North America

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“…It is estimated that 30 % of SSc patients are at medium to high risk for malnutrition [81]. Patients should be aware of warning signs such as sudden weight loss and undergo yearly screening by a rheumatologist.…”

Section: Gastrointestinal Manifestationsmentioning

confidence: 99%

Update on Systemic Sclerosis

McCray

Mayes

2015

Curr Allergy Asthma Rep

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Systemic sclerosis (SSc) is a rare autoimmune disease characterized by autoantibody production, small-vessel vasculopathy, and skin and other organ fibrosis. The disease is clinically heterogeneous with most patients having some degree of skin sclerosis with varying organ system involvement. Early disease can be difficult to diagnose, especially with minimal skin sclerosis and absence of anti-nuclear antibody (ANA) positivity; however, studies have demonstrated early diagnosis is important as early treatment could potentially lead to better outcomes. New classification criteria have recently been published that have higher sensitivity for detecting early disease thus allowing for a broader spectrum of patients to be represented in clinical trials. Treatment guidelines have been published based on a limited number of randomized-controlled clinical trials; however, there are ongoing phase II and III clinical trials with novel agents that are promising and will change the treatment landscape over the next decade.

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Malnutrition Is Common in Systemic Sclerosis: Results from the Canadian Scleroderma Research Group Database

Abstract: The risk for malnutrition in SSc is moderate and is associated with shorter disease duration, markers of GI involvement, and disease severity. Patients with SSc should be screened for malnutrition, and potential underlying causes assessed and treated when possible.

Cited by 124 publications

References 37 publications

Gastrointestinal Manifestations of Scleroderma: Recent Progress in Evaluation, Pathogenesis, and Management

Gastrointestinal Manifestations of Scleroderma: Recent Progress in Evaluation, Pathogenesis, and Management

Systemic Sclerosis

Update on Systemic Sclerosis

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