Malnutrition Is Associated with Increased Blood Pressure in Childhood

Sesso, Ricardo; Barreto, Gênia Pithon; Neves, Janaína das; Sawaya, Ana Lydia

doi:10.1159/000078402

Cited by 32 publications

(49 citation statements)

References 13 publications

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“…In contrast to the findings of the present study, Sesso et al 13 conducted a crosssectional study with 172 children over 2 years of age; of these, 91 were classified as malnourished with a Z-score of −1 in relation to height and weight for their age. Of the group of malnourished children, 29% showed an increase in SBP and DBP after adjustment for age, sex, and height when compared with the control children (2%).…”

Section: Discussioncontrasting

confidence: 87%

Impact of malnutrition on cardiac autonomic modulation in children

Barreto

Vanderlei

et al. 2016

Jornal de Pediatria

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Section: Discussioncontrasting

confidence: 87%

Impact of malnutrition on cardiac autonomic modulation in children

Barreto

Vanderlei

et al. 2016

Jornal de Pediatria

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“…Briefly, we found that nutritional stunting, a factor previously reported to increase the risk of hypertension [7][8][9] Values are expressed as mean, with the (95% CI given in parenthesis and later obesity [5], was associated with high ACE activity in childhood and that the adjustment by gender did not modify the strength of this association. Additionally, a greater percentage of stunted children had increased BP levels, and this clinical parameter was inversely correlated with anthropometric indicators.…”

Section: Discussionmentioning

confidence: 99%

“…However, childhood malnutrition remains extremely common in many developing countries, and associations with later disease need to be established. In fact, childhood nutritional stunting, an indicator of chronic malnutrition, has been suggested as one factor that can contribute to high incidences of obesity [5], impaired glucose metabolism [6] and hypertension [7][8][9] in developing countries. A series of studies in Brazil demonstrated that alterations in blood pressure (BP) levels are associated with stunted growth in children, adolescents and adults.…”

Section: Introductionmentioning

confidence: 99%

“…A series of studies in Brazil demonstrated that alterations in blood pressure (BP) levels are associated with stunted growth in children, adolescents and adults. Sesso et al [7] reported that BP levels were increased in malnourished children and in those who recovered from malnutrition after an average period of 6 years. Fernandes et al [8] described a high prevalence of arterial hypertension in a group of adolescents with mild malnutrition who were living under conditions of extreme poverty.…”

Section: Introductionmentioning

confidence: 99%

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Stunting growth: association of the blood pressure levels and ACE activity in early childhood

et al. 2009

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Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II and inactive bradykinin. Several studies carried out in our laboratory have consistently identified three isoforms of ACE, at 65, 90 and 190 kDa, with the 90-kDa isoform being a possible genetic marker of hypertension. Based on these observations and the fact that nutritional stunting can be associated with hypertension, we have investigated the expression and activity of ACE in stunted children and its association with blood pressure (BP) levels and nutritional state. Sixty children aged 2-7 years were selected for this study. A urine sample was collected from each child. Angiotensin converting enzyme activity was evaluated using two different substrates, and ACE expression was detected by Western blotting. Our results show that nutritional stunting is associated with high ACE activity in childhood and that adjustment by gender does not modify the strength of this association. A greater percentage of stunted children had increased BP levels, and this clinical parameter was inversely correlated with anthropometric indicators. A greater urinary protein expression of the three ACE isoforms was observed in the group of children with growth stunting. Our findings suggest that the reported high risk of hypertension in stunted adolescents and adults are, at least partly, associated with abnormalities in the renin-angiotensin system.

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“…8 However, malnutrition is also associated with increased Blood Pressure. 9 Protein Energy Malnutrition remains a major public health problem in many countries including India, but there is scanty information available about the effects of malnutrition on blood pressure. Low socioeconomic status is associated with higher blood pressure.…”

Section: Introductionmentioning

confidence: 99%

Study of blood pressure profile and anthropometry in children belonging to low socio-economic status; a prospective cross sectional study

Sudhakar

Rahman

2017

Int J Contemp Pediatr

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Background: A significant number of population in India are below poverty line. It contributes to the higher incidence of malnutrition especially among children which is 48% according to NFHS-3 (National family Health survey). Blood Pressure tracking studies suggest that hypertension in adulthood often has its origin in childhood. Blood pressure in childhood is the best predictor of hypertension in later life. There have been very few studies on malnutrition and Hypertension association and none in this area. One rationale for screening for hypertension in children and adolescents is that early identification of primary hypertension could lead to interventions to reduce blood pressure during childhood and adolescence, resulting in a reduced risk for cardiovascular events and death in adulthood. Methods: The present cross sectional prospective study was conducted on School going children (5-14 years) belonging to lower socio-economic status attending schools from Bhilai, District Durg Chhattisgarh, India, within 5 km range of Chandulal Chandrakar Memorial Hospital over a period of 12 months from March 2015 to February 2016.The present study took 300 sample size. List of schools was arranged from district education officer (DEO) and required government schools were shortlisted on within 5 km range of hospital. After short history and examination, as per the prerequisite of proforma, the following measurements were taken. For all the statistical analysis MS EXCEL and SPSS 16 (Statistical Package for Social Science) version were used. The information collected was tabulated and the data was analyzed using suitable statistics. Results: 60% of the subjects were belongs to 5-10 years of age and 40% in 10-14 years' age group. Males and females were equal in distributions (50% each), thus there were 150 males and 150 females in the current study. Overall prevalence of malnutrition in our study was 38.6%. The present study found 88 subjects (29.3%) having grade 1 malnutrition and 28 subjects (38.7%) having grade 2 and 0 (0%) with grade 3 and grade 4 malnutrition. There were 2 pre-hypertensives in our study, out of which one was male and one female. When analyzed according to nutritional status, there were 2 hypertensives in malnourished group. Similarly. there was 1 hypertensive in normal nutritional status group. Conclusions: There is a significant prevalence of malnutrition in our society which contributes to a more number of problems than what is presented to practicing paediatricians. The prevalence is higher in children <5 years age group overall which continues through school age and adolescent age group as shown in our study. The focus of attention should be identification of various diseases along with hypertension at the earliest and prevention of malnutrition.

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Malnutrition Is Associated with Increased Blood Pressure in Childhood

Cited by 32 publications

References 13 publications

Impact of malnutrition on cardiac autonomic modulation in children

Impact of malnutrition on cardiac autonomic modulation in children

Stunting growth: association of the blood pressure levels and ACE activity in early childhood

Study of blood pressure profile and anthropometry in children belonging to low socio-economic status; a prospective cross sectional study

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