Malnutrition is associated with dementia severity and geriatricsyndromes in patients with Alzheimer disease

Yıldız, Demet; Pekel, Nilüfer Büyükkoyuncu; Tolgay, Elif Nalan; Tufan, Fatih

doi:10.3906/sag-1406-76

Cited by 33 publications

(31 citation statements)

References 14 publications

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“…Several possible mechanisms have been suggested to explain the effect of serum albumin on MCI risk. First, serum albumin is associated with nutritional status in elderly (Covinsky et al 2002), and persistent malnutrition plays an important role in cognitive impairment (Yildiz et al 2015;Karakis et al 2016). Therefore, relatively low serum level of albumin partly reflects the malnutrition, which promotes the progression of MCI.…”

Section: Discussionmentioning

confidence: 99%

Inverse Relationship between Baseline Serum Albumin Levels and Risk of Mild Cognitive Impairment in Elderly: A Seven-Year Retrospective Cohort Study

Wang

Liu

et al. 2018

Tohoku J. Exp. Med.

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Mild cognitive impairment (MCI) is the prophase of dementia. MCI patients have a high risk of developing dementia. Relatively low serum albumin levels are associated with the development of several geriatric diseases, including stroke and poor cognitive performance. However, the potential relationship between serum albumin levels and MCI risk has not been fully elucidated. In the present study, we explored this relationship to increase our understanding of the pathogenesis of MCI, the finding of which may provide new ideas for the controlling of dementia. A total of 1,800 subjects who had normal cognitive function at their first health examinations (seven years ago) were retrospectively analyzed from a health database in Tianjin Medical University General Hospital. They were over 60 years old at baseline, and the follow-up period was 7 years. At the time of data collection (seven years after), 196 subjects suffered from MCI, diagnosed by symptoms and Mini-Mental State Examination. The remaining 1,604 subjects were still cognitively normal. Multivariate COX regression analysis showed that relatively low serum albumin levels at baseline (< 40.5 g/L) were associated with the increased risk of MCI (HR: 2.18, 95% CI: 1.67-2.82). Moreover, the effect of low serum albumin on the risk of MCI was further enhanced among the subjects with hypertension, diabetes, hyperlipemia, cardiovascular disease, cerebrovascular disease, high serum levels of C-reactive protein, or relatively low levels of uric acid or total bilirubin. In conclusion, relatively low serum concentrations of albumin may be an independent risk factor for MCI in elderly.

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Section: Discussionmentioning

confidence: 99%

Inverse Relationship between Baseline Serum Albumin Levels and Risk of Mild Cognitive Impairment in Elderly: A Seven-Year Retrospective Cohort Study

Wang

Liu

et al. 2018

Tohoku J. Exp. Med.

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“…Dietary patterns of older adults usually contain low amounts of macro and micronutrients (calcium, iodine, vitamin B2, zinc, phosphorus, and vitamin B12) [Rakıcıoğlu et al, 2015] and it is high in carbohydrates [Boirie et al, 2014]. Dietary imbalances in older adults may determine several systemic conditions, including, frailty [Boulos et al, 2016], sarcopenia [Relph, 2016], dependency [Yildiz et al, 2015], dementia [Naseer et al, 2016], sleep disorders [Yildiz et al, 2015], increased risk of falls [Masumoto et al, 2015], mortality [Tsai et al, 2016] and higher rates of hospitalization [Geurden et al, 2015]. As a way to counteract this problem, a range of dietary supplements including milk-based drinks fortified with different nutrients are commercially available.…”

Section: Introductionmentioning

confidence: 99%

Cariogenicity of a Milk-Based Drink Used as a Dietary Supplement for Older Adults Using a Root Caries Experimental Model

et al. 2018

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The aim of this study was to evaluate the cariogenicity of a milk-based drink intended for older adults that was used as part of a governmental initiative in Chile to improve their nutritional conditions. This drink contains a high concentration of sugars, which can contribute to root caries development. To test this hypothesis, an experimental biofilm/caries model was used. Dentin slabs were used to grow biofilms of Streptococcus mutans UA159. Slabs/biofilms were exposed 3× per day to bovine milk with different fat content, the milk-based drink, and the milk-based drink supplemented with 10 g of sucrose added per serving. Slabs exposed to 10% sucrose or 0.9% NaCl were used as positive and negative controls, respectively. Biofilms were analyzed for bacterial counts and acidogenicity. Dentin demineralization was estimated by the loss of surface microhardness and integrated mineral loss. Results were compared by analysis of variance and Tukey’s test. The milk-based drink showed higher acidogenicity than milk with its entire (whole) or reduced total fat content (skim). The milk-based drink supplemented with sucrose had similar acidogenicity as the 10% sucrose positive control (p = 0.506). Whole milk exposure elicited lower bacterial counts than the positive control, the milk-based drink, and the milk-based drink supplemented with sucrose (p = 0.002; 0.006 and 0.014 respectively). Although skim milk induced higher demineralization than whole milk, both milk types produced lower demineralization than the milk-based drink. Regarding integrated mineral loss, demineralization induced by the milk-based drink and the milk-based drink supplemented with sucrose was similar to that induced by the positive control and skim milk (p > 0.05). Sugar-containing milk-based drinks used as dietary supplements for older adults may be highly cariogenic and could represent a potential risk for root caries.

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“…Cova et al (2016) reported that progression towards AD and dementia is expected when weight loss is observed in mild cognitive impairment. Malnutrition is associated with dementia severity and geriatric syndrome in AD patients (Yildiz et al, 2015). Various explanations have been proposed for weight loss such as atrophy of mesial temporal cortex, biological disturbance or feeding behavior.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Plant Food Extracts in Experimental Model of Alzheimer's Like Disease Induced by Aluminum Lactate in Rats

2017

J App Pharm Sci

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In the present research, the beneficial effect of plant food extracts in Alzheimer's like model, induced by aluminum, was studied in rats. A healthy control group without any treatments and a control with induced Alzheimer's like disease (ALD) were run. Tests groups of rats were treated with daily oral doses of methanol extract of Carica papaya leaves and fruits, Vitis venifera leaves and fruits, Origanum majorana herb, and petroleum ether extract of Carica papaya seeds separately for 5 weeks. Rats of test groups and control ALD received daily intraperitoneal injection of aluminum lactate starting from the 2 nd week. Plasma and brain tissues were biochemically analyzed. Control rats with ALD demonstrated a significant increase in erythrocyte sedimentation rate, plasma malondialdehyde, nitrite, tumor necrosis factor -alpha and cholinesterase activity with significant reduction in plasma vitamin C and E compared to control healthy rats. Brain malondialdehyde and acetyl cholinesterase activity showed significant elevation in control rats with ALD. The studied plant extracts showed efficient inhibition of oxidative stress, inflammation, and cholinesterase activity in plasma and brain with variable degrees. Both brain oxidative stress and acetyl cholinesterase activity were reduced by methanol extracts of Vitis venifera and Carica papya fruits.

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Malnutrition is associated with dementia severity and geriatricsyndromes in patients with Alzheimer disease

Cited by 33 publications

References 14 publications

Inverse Relationship between Baseline Serum Albumin Levels and Risk of Mild Cognitive Impairment in Elderly: A Seven-Year Retrospective Cohort Study

Inverse Relationship between Baseline Serum Albumin Levels and Risk of Mild Cognitive Impairment in Elderly: A Seven-Year Retrospective Cohort Study

Cariogenicity of a Milk-Based Drink Used as a Dietary Supplement for Older Adults Using a Root Caries Experimental Model

Evaluation of Plant Food Extracts in Experimental Model of Alzheimer's Like Disease Induced by Aluminum Lactate in Rats

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