Malnutrition inflammation score (MIS) is stronger predictor of mortality in hemodialysis patients than waist-to-hip ratio (WHR)-4-year follow-up

Prelević, Vladimir; Antunović, Tanja; Radunović, Danilo; Gligorovic-Barhanovic, Najdana; Gledovic, Branka; Ratković, Marina; Jukić, Nikolina Bašić

doi:10.1007/s11255-021-02954-z

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…(29) In a four-year follow-up study of survival rates in hemodialysis patients, 100 patients were enrolled, initially 16 patients had MIS score <11, 55 patients had scores 12 or 13, and 29 patients had scores >14. (30) Although the present study did not investigate any correlation with mortality as it is a cross-sectional study, it was found that there was significant correlation between MIS and age (r = 0.221), total energy intake (r = -0.468), total protein intake (r = -0.368), dry body weight (r = -0.341) and BMI (r = -0.282). Gencer et al (2019) did not find any significant correlation between age and MIS (r = 0.097), they also found a significant negative correlation between MIS and body weight (r = -0.312).…”

Section: Discussionmentioning

confidence: 56%

Intradialytic Feeding Practice and Nutritional Status of Maintenance Hemodialysis Patients in Alexandria, Egypt

Elkeraie,

Amine,

Naga

et al. 2023

Journal of High Institute of Public Health

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Background: Malnutrition is a common complication of hemodialysis that needs to be prevented, properly diagnosed and treated. Intra-dialytic feeding is a controversial yet effective method to help improve nutritional status. Objective(s):To assess intradialytic dietary pattern and nutritional status of hemodialysis patients and determine the energy and protein adequacy on hemodialysis and non-hemodialysis days. Methods: A cross sectional study was conducted using a predesigned interview questionnaire, 3-day 24-hour diet recall, anthropometric measurements, serum albumin and total iron binding capacity measurements, and malnutrition inflammation score (MIS) for 150 hemodialysis patients. Results: More than three quarters of the patients reported eating during the hemodialysis session with 71.3% of them eating due to the long session hours. Mean energy and protein intake on hemodialysis days was 1743.0 ± 718.1 kcal and 73.78 ± 37.15 g, respectively, which was significantly higher among patients who eat than those who don't eat during the hemodialysis session (p<0.001). Although mean serum albumin was higher in patients who eat during dialysis session and MIS was lower, there was no statistically significant difference between both groups. Conclusion: Intradialytic feeding is a common practice in chronic hemodialysis patients. Both energy and protein intakes and their adequacies were found to be higher in patients who eat during the dialysis session. This hints at the importance of utilization of dialysis session time to enhance the patients' nutritional status. Therefore, it is recommended to individualize the advice of intradialytic feeding according to the patient's needs.

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Section: Discussionmentioning

confidence: 56%

Intradialytic Feeding Practice and Nutritional Status of Maintenance Hemodialysis Patients in Alexandria, Egypt

Elkeraie,

Amine,

Naga

et al. 2023

Journal of High Institute of Public Health

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“…The MIS is a useful and widely employed measure of nutritional status for patients on maintenance dialysis. It has been shown to be a strong predictor of mortality in these patient [42]. By identifying nutritional de ciencies through MIS, healthcare professionals can pinpoint patients at higher risk for sarcopenia, highlighting malnutrition as a signi cant risk factor for the severity of sarcopenia.…”

Section: Malnutrition Assessmentmentioning

confidence: 99%

The Role of Medication Literacy and Polypharmacy in Sarcopenia Among Maintenance Hemodialysis Patients: A Cross-Sectional Analysis

Zhu,

Liu,

Yang

et al. 2024

Preprint

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Purpose Sarcopenia is significantly prevalent among maintenance hemodialysis patients, with the contributing factors of medication literacy and polypharmacy receiving limited exploration in current research. This study aims to fill this gap by assessing the impact of these factors, along with demographic and malnurtition, on sarcopenia risk. Methods Conducted at the Wenjiang Hemodialysis Center in West China Hospital, this descriptive cross-sectional study involved 236 participants. Data collection included the Chinese Medication Literacy Scale, Malnutrition-Inflammation Score assessments, bioelectrical impedance analysis, and grip strength measurements, with sarcopenia diagnosed according to the 2019 AWGS criteria. Results The study included 236 participants. Of these, 87 (36.9%) had no sarcopenia, 121 (51.3%) were pre-sarcopenia, 7 (3.0%) were sarcopenia, and 21 (8.9%) had severe sarcopenia. Ordinal logistic regression analysis identified male gender (OR = 0.557, 95% CI: 0.322 to 0.962, P = 0.036), age below 65 (OR = 0.178, 95% CI: 0.082 to 0.389, P < 0.001), and good nutritional status (OR = 0.544, 95% CI: 0.310 to 0.954, P = 0.034) as protective against severe sarcopenia. Conversely, the combination of polypharmacy and limited medication literacy (OR = 1.956, 95% CI: 1.094 to 3.496, P = 0.024) was significantly associated with an increased risk of sarcopenia progression. Conclusion The study highlights the protective role of good nutrition and the lesser susceptibility of males and younger individuals to severe sarcopenia. It underscores the necessity of targeted interventions to address the compounded risk presented by polypharmacy and limited medication literacy in patients undergoing hemodialysis.

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“…Malnutrition, with a prevalence between 40% and 75% in MHD patients, 1 , 2 is the most important risk factor for morbidity, the quality of life, all-cause mortality and cardiovascular mortality. 3–5 Chronic systemic inflammation is highly correlated with high cardiovascular disease (CVD) mortality and overall mortality in individuals undergoing hemodialysis. 6 Malnutrition and inflammation are closely intertwined in MHD patients.…”

Section: Introductionmentioning

confidence: 99%

Diet-Related Inflammation is Associated with Malnutrition-Inflammation Markers in Maintenance Hemodialysis Patients: Results of a Cross-Sectional Study in China Using Dietary Inflammatory Index

Zeng¹,

Lin²,

He³

et al. 2022

IJGM

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Purpose This cross-sectional study aimed to explore the association between the inflammation potential of the diet and malnutrition-inflammation status in Chinese maintenance hemodialysis (MHD) patients. Methods Dietary Inflammatory Index (DII) was computed based on a semi-quantitative food frequency questionnaire. Malnutrition-inflammation status was assessed by six indexes, including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), hemoglobin (HB), albumin (ALB) and malnutrition-inflammation score (MIS). Multivariable linear regression and logistic regression were employed adjusting for covariables including age, gender, body mass index and dialysis vintage. Results A total of 161 Chinese MHD patients with an average age of 60.0 ± 13.6 years were enrolled. The median (IQR) DII score among participants was 0.60 (−0.80, 2.32), revealing a generally pro-inflammatory diet. DII was positively associated with MIS score (β= 0.61, 95% CI: 0.51, 0.69, p < 0.0001) and CRP (β = 0.54, 95% CI: 0.46, 0.63, p < 0.0001). A negative relationship between DII and NLR (β = −0.37, 95% CI: −0.61, −0.13, p = 0.008) was found in the most anti-inflammatory diet. Multivariable logistic regression showed that each unit increase in DII was linked with 3.06 (95% CI: 1.39, 6.69, p = 0.005) times increased odds of MIS. Conclusion Diet with a higher DII score may act as a potential trigger contributing to the development of malnutrition-inflammation status. Further studies for verification and for developing strategies to decrease the dietary inflammation burden are warranted.

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Malnutrition inflammation score (MIS) is stronger predictor of mortality in hemodialysis patients than waist-to-hip ratio (WHR)-4-year follow-up

Cited by 7 publications

References 11 publications

Intradialytic Feeding Practice and Nutritional Status of Maintenance Hemodialysis Patients in Alexandria, Egypt

Intradialytic Feeding Practice and Nutritional Status of Maintenance Hemodialysis Patients in Alexandria, Egypt

The Role of Medication Literacy and Polypharmacy in Sarcopenia Among Maintenance Hemodialysis Patients: A Cross-Sectional Analysis

Diet-Related Inflammation is Associated with Malnutrition-Inflammation Markers in Maintenance Hemodialysis Patients: Results of a Cross-Sectional Study in China Using Dietary Inflammatory Index

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