Malnutrition-induced macrophage apoptosis

Rivadeneira, David E.; Grobmyer, Stephen R.; Naama, Hassan A.; Mackrell, Peter J.; Mestre, Juan R.; Stapleton, Philip P.; Daly, J.M.

doi:10.1067/msy.2001.112963

Cited by 79 publications

(45 citation statements)

References 24 publications

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“…FerreiraSilva et al 24 found a reduction in the viability of alveolar macrophages after perinatal malnutrition. Corroborating these authors, Rivadeneira et al 29 found that malnutrition is associated with increased apoptosis. Apoptosis can be triggered by external stimuli or internal stimuli that result in mitochondrial dysfunction, DNA damage, and Revista de Nutrição http://dx.doi.org/10.1590/1415-52732014000500005 alteration of nutritional and growth factors.…”

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confidence: 75%

“…Apoptosis can be triggered by external stimuli or internal stimuli that result in mitochondrial dysfunction, DNA damage, and Revista de Nutrição http://dx.doi.org/10.1590/1415-52732014000500005 alteration of nutritional and growth factors. These different routes induce activation of caspases, which generate the cleavage of structural proteins, impairing cytoskeleton integrity, resulting in cell death 29 .…”

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confidence: 99%

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Long-term effects of neonatal malnutrition on microbicide response, production of cytokines, and survival of macrophages infected by Staphylococcus aureus sensitive/resistant to methicillin

et al. 2014

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OBJECTIVE: To assess microbicide function and macrophage viability after in vitro cellular infection by methicillin-sensitive/resistant Staphylococcus aureus in nourished rats and rats subjected to neonatal malnutrition. METHODS: Male Wistar rats (n=40) were divided in two groups: Nourished (rats suckled by dams consuming a 17% casein diet) and Malnourished (rats suckled by dams consuming an 8% casein diet). Macrophages were recovered after tracheotomy, by bronchoalveolar lavage. After mononuclear cell isolation, four systems were established: negative control composed exclusively of phagocytes; positive control composed of macrophages plus lipopolysaccharide; and two testing systems, macrophages plus methicillin-sensitive Staphylococcus aureus and macrophages plus methicillin-resistant Staphylococcus aureus. The plates were incubated in a humid atmosphere at 37 degrees Celsius containing 5% CO2 for 24 hours. After this period tests the microbicidal response, cytokine production, and cell viability were analyzed. The statistical analysis consisted of analysis of variance (p<0.05). RESULTS: Malnutrition reduced weight gain, rate of phagocytosis, production of superoxide anion and nitric oxide, and macrophage viability. Production of nitrite and interleukin 18, and viability of macrophages infected with methicillin-resistant Staphylococcus aureus were lower. CONCLUSION: The neonatal malnutrition model compromised phagocyte function and reduced microbicidal response and cell viability. Interaction between malnutrition and the methicillin-resistant strain decreased the production of inflammatory mediators by effector cells of the immune response, which may compromise the immune system's defense ability.

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confidence: 75%

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confidence: 99%

Long-term effects of neonatal malnutrition on microbicide response, production of cytokines, and survival of macrophages infected by Staphylococcus aureus sensitive/resistant to methicillin

et al. 2014

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“…Hypoalbuminemia was associated with poor tissue healing, decreased collagen synthesis in the surgical wounds or at the anastomosis [19][20][21] , and impairment of immune responses, such as macrophage activation and granuloma formation [22,23] . Therefore, in hypoalbuminemic patients, wound infection, remote infections such as pneumonia, and anastomotic leakage, were commonly found.…”

Section: Discussionmentioning

confidence: 99%

Pre-operative hypoalbuminemia is a major risk factor for postoperative complications following rectal cancer surgery

Lohsiriwat¹,

Lohsiriwat²,

Boonnuch³

et al. 2008

WJG

119

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AIM:To determine the relationship between preoperative hypoalbuminemia and the development of complications following rectal cancer surgery, as well as postoperative bowel function and hospital stay. METHODS:The medical records of 244 patients undergoing elective oncological resection for rectal adenocarcinoma at Siriraj Hospital during 2003 and 2006 were reviewed. The patients had pre-operative serum albumin assessment. Albumin less than 35 g/L was recognized as hypoalbuminemia. Postoperative outcomes, including mortality, complications, time to first bowel movement, time to first defecation, time to resumption of normal diet and length of hospital stay, were analyzed. RESULTS:The patients were 139 males (57%) and 105 females (43%) with mean age of 62 years. Fifty-six patients (23%) had hypoalbuminemia. Hypoalbuminemic patients had a significantly larger tumor size and lower body mass index compared with non-hypoalbuminemic patients (5.5 vs 4.3 cm; P < 0.001 and 21.9 vs 23.2 kg/m 2 ; P = 0.02, respectively). Thirty day postoperative mortality was 1.2%. Overall complication rate was 25%. Hypoalbuminemic patients had a significantly higher rate of postoperative complications (37.5% vs 21.3%; P = 0.014). In univariate analysis, hypoalbuminemia and ASA status were two risk factors for postoperative complications. In multivariate analysis, hypoalbuminemia was the only significant risk factor (odds ratio 2.22, 95% CI 1.17-4.23; P < 0.015). Hospitalization in hypoalbuminemic patients was significantly longer than that in non-hypoalbuminemic patients (13 vs 10 d, P = 0.034), but the parameters of postoperative bowel function were not significantly different between the two groups. CONCLUSION:Pre-operative hypoalbuminemia is an independent risk factor for postoperative complications following rectal cancer surgery.

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“…Macrophage is, in fact, the first line of defense against intracellular microbial pathogens. It has been proved (Rivadeneira et al 2001) on a cellular level that malnutrition can induce macrophage apoptosis, which is crucial in immuno-resistance to infectious diseases, particularly in the mechanism of TB infection.…”

Section: Risk Factors and Socio-economic Background Of Tuberculosismentioning

confidence: 99%

Evidence of tuberculosis among children in medieval (13th–15th century) Wrocław: A case study of hip joint tuberculosis in a juvenile skeleton excavated from the crypt of the St. Elizabeth church

Cieślik

2017

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Paleopathological examinations of the skeletal remains of people who died centuries ago are material source of knowledge about health and diseases in the past. In this article, a case of skeletal tuberculosis from historical (13th-15th c.) Wrocław, Poland has been presented. The juvenile skeleton excavated from grave No 93, from the crypt located under the church of St. Elizabeth, displayed pathological lesions within the right hip joint resulting from a chronic inflammation, which might have been assigned to signs typical for skeletal tuberculosis. The results of macroscopic and radiological analyses appeared to be consistent, and allowed to determine a reliable diagnosis of this paleopathological case.

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Malnutrition-induced macrophage apoptosis

Cited by 79 publications

References 24 publications

Long-term effects of neonatal malnutrition on microbicide response, production of cytokines, and survival of macrophages infected by Staphylococcus aureus sensitive/resistant to methicillin

Long-term effects of neonatal malnutrition on microbicide response, production of cytokines, and survival of macrophages infected by Staphylococcus aureus sensitive/resistant to methicillin

Pre-operative hypoalbuminemia is a major risk factor for postoperative complications following rectal cancer surgery

Evidence of tuberculosis among children in medieval (13th–15th century) Wrocław: A case study of hip joint tuberculosis in a juvenile skeleton excavated from the crypt of the St. Elizabeth church

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