Malnutrition in pre-dialysis chronic kidney disease patients in a teaching hospital in Southern Nigeria

Adejumo, Oluseyi Ademola; Enajite, Okaka

doi:10.4314/ahs.v16i1.31

Cited by 26 publications

(28 citation statements)

References 31 publications

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“…This finding was similar to the Southern Nigeria study which reported that malnutrition was significantly commoner in elderly patients (p=0.047). 20 …”

Section: Discussionmentioning

confidence: 99%

<p>Protein-Energy Wasting and Associated Factors Among Chronic Kidney Disease Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia</p>

Merga

Girma

Teshome

2020

IJNRD

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Background Protein-energy wasting is a major issue in patients with chronic kidney disease (CKD), adversely affecting morbidity, mortality, functional activity, and quality of life. Assessment of nutritional status in CKD patients is important to ensure patient’s normal protein stores and avoid metabolic complications. However, in Ethiopia, there were very few studies done to assess the prevalence of protein-energy wasting (PEW) and its associated factors among CKD patients. Objective To assess protein-energy wasting and associated factors among chronic kidney disease patients at adult OPD St. Paulo’s Hospital Millennium Medical College, Addis Ababa Ethiopia. Materials and Methods An institution-based cross-sectional study was conducted from March to April 2019. Data were collected using a structured interviewer-administered questionnaire and anthropometric measurements, and laboratory data were collected from patient files. Data were entered into Epi-data version 3.1 and analyzed using SPSS version 20. Both bivariate and multiple logistic regression analyses were performed to identify associated factors. P values <0.05 were considered to declare statistical significance. Results In this study, 274 respondents were interviewed with a response rate of 100%. The prevalence of protein-energy wasting in CKD patients was 23.4%. Chronic kidney disease patients at age ≥65 years were seven times more likely to have protein-energy wasting as compared to patients aged 18–34 years [AOR=7.0, 95% (CI: 2.4, 20.5)]. Patients who had a history of anorexia were 5.2 times more likely to have protein-energy wasting as compared to those who had no history of anorexia [(AOR=5.2, 95% (CI: 2.7, 10.3)] and were significantly associated with the risk of having CKD. Conclusion The prevalence of protein-energy wasting among CKD patients was high and associated with age, physical activity, history of anorexia, and CKD stages. Interventions that address nutritional problems and lifestyle factors in CKD patients need to be implemented together with medical treatment.

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“…This finding was similar to the Southern Nigeria study which reported that malnutrition was significantly commoner in elderly patients (p=0.047). 20 …”

Section: Discussionmentioning

confidence: 99%

<p>Protein-Energy Wasting and Associated Factors Among Chronic Kidney Disease Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia</p>

Merga

Girma

Teshome

2020

IJNRD

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“…Reduced serum albumin is considered a strong predictor of morbidity and mortality in the CKD population in all stages and, with other clinical parameters, is an indicative of dialysis therapy initiation 19,20 . In addition, hypoalbuminemia may indicate inflammation and depletion of nutritional status 21 .…”

Section: Discussionmentioning

confidence: 99%

“…Reduction of MAC values, regardless of body weight and state of hydration and inflammation, may suggest decreased muscle mass. Reduction of lean mass, inflammatory state, and hypoalbuminemia are considered risk factors for cardiovascular disease, increased mortality, and rapid progression of CKD 20 .…”

Section: Discussionmentioning

confidence: 99%

Longitudinal changes in nutritional parameters and resting energy expenditure in end-stage renal disease

et al. 2020

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Aims: To evaluate the nutritional status, resting energy expenditure, caloric and protein intake, and evolution of biochemical parameters in three stages of chronic kidney disease: pre-dialytic, at the beginning of the dialysis treatment, and 30 days after starting treatment. Methods: The chi-square and Student’s t tests were used to compare the variables, and analysis of repeated measurements was used to compare the data obtained in the three moments evaluated. The results were discussed at the 5% level of significance. Results: We evaluated 35 patients, 60% female and 60% with diabetes mellitus. There was a decrease in midarm circumference and serum albumin. Inflammatory state and caloric and protein intake increased. There was no significant difference in resting energy expenditure in the three moments. The serum urea and serum albumin, handgrip strength, and protein consumption after 30 days from the start of dialysis were greater in the peritoneal dialysis patients, when compared to the hemodialysis population. Conclusion: there was a decrease in midarm circumference and serum albumin and an increase in protein intake after dialysis. The peritoneal dialysis patients had higher muscle strength, even with lower protein intake. Resting energy expenditure was not different between dialysis methods and the moments evaluated.

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“…47 Malnutrition in turn is associated with reduced quality of life, sleep problems, depression, erythropoietin hypo-responsiveness, immunosuppression, and heart failure exacerbation in patients with ESKD. 47 Malnutrition in itself is already associated with increased all-cause mortality and MACE rates in subjects with CAD. 48 In this specific population of patients after KT, malnutrition is associated with longer transplant hospitalization length of stays, higher all-cause graft loss, and higher mortality.…”

Section: Discussionmentioning

confidence: 99%

Acute coronary syndromes in the peri‐operative period after kidney transplantation in United States

Goyal

Chatterjee

et al. 2020

Clinical Transplantation

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It is well known that chronic kidney disease (CKD) is an independent risk factor for the development of cardiovascular disease (CVD). 1 The risk of cardiovascular mortality goes up with progressive decline in estimated glomerular filtration rate (eGFR). 2,3 In fact, among patients with end-stage kidney disease (ESKD), there is up to a 30-fold increase in cardiovascular and all-cause mortality. 2,4 While kidney transplantation (KT) decreases the burden of cardiovascular disease (CVD) when compared to patients who remain on dialysis, the rates of major adverse cardiovascular events (MACE) are still higher compared to the general population. 5-7 In various prospective studies, the incidence of MACE after KT range from 5% to 20% and cardiovascular events can account for over 50% of all-cause mortality in KT recipients. 7-11 These adverse cardiovascular events may occur

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Malnutrition in pre-dialysis chronic kidney disease patients in a teaching hospital in Southern Nigeria

Cited by 26 publications

References 31 publications

<p>Protein-Energy Wasting and Associated Factors Among Chronic Kidney Disease Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia</p>

<p>Protein-Energy Wasting and Associated Factors Among Chronic Kidney Disease Patients at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia</p>

Longitudinal changes in nutritional parameters and resting energy expenditure in end-stage renal disease

Acute coronary syndromes in the peri‐operative period after kidney transplantation in United States

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