Malnutrition in older adults

Dent, Elsa; Wright, Olivia; Woo, Jean; Hoogendijk, Emiel O.

doi:10.1016/s0140-6736(22)02612-5

Cited by 82 publications

(60 citation statements)

References 118 publications

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“…First, we used the PubMed database [ 75 ] and characterized each of the 39 novel PAG-related DEGs of the tame and aggressive rats ( Table 2 ) by answering the question as to how under- or overexpression of their human orthologs can aggravate or alleviate ARDs [ 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , ...…”

Section: Resultsmentioning

confidence: 99%

Differentially Expressed Genes and Molecular Susceptibility to Human Age-Related Diseases

Shikhevich

Chadaeva

Khandaev

et al. 2023

IJMS

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Mainstream transcriptome profiling of susceptibility versus resistance to age-related diseases (ARDs) is focused on differentially expressed genes (DEGs) specific to gender, age, and pathogeneses. This approach fits in well with predictive, preventive, personalized, participatory medicine and helps understand how, why, when, and what ARDs one can develop depending on their genetic background. Within this mainstream paradigm, we wanted to find out whether the known ARD-linked DEGs available in PubMed can reveal a molecular marker that will serve the purpose in anyone’s any tissue at any time. We sequenced the periaqueductal gray (PAG) transcriptome of tame versus aggressive rats, identified rat-behavior-related DEGs, and compared them with their known homologous animal ARD-linked DEGs. This analysis yielded statistically significant correlations between behavior-related and ARD-susceptibility-related fold changes (log2 values) in the expression of these DEG homologs. We found principal components, PC1 and PC2, corresponding to the half-sum and the half-difference of these log2 values, respectively. With the DEGs linked to ARD susceptibility and ARD resistance in humans used as controls, we verified these principal components. This yielded only one statistically significant common molecular marker for ARDs: an excess of Fcγ receptor IIb suppressing immune cell hyperactivation.

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Section: Resultsmentioning

confidence: 99%

Differentially Expressed Genes and Molecular Susceptibility to Human Age-Related Diseases

Shikhevich

Chadaeva

Khandaev

et al. 2023

IJMS

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“…Internationally recognised nutrition care recommendations and guidelines clearly articulate the need for inpatients with or at risk of malnutrition to (i) receive timely, systematic assessment and diagnostic advice; (ii) be involved in their care planning and decision making processes; (iii) receive multimodal and multidisciplinary interventions; (iv) receive nutritional information, education, or counselling; and (v) work with care providers to coordinate the transition of care into post-hospital settings [ 9 , 13 , 20 , 21 ]. The lack of engagement of patients across these core components of care raises potential ethical concerns regarding informed consent and shared decision making [ 11 , 14 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…Despite increased attention to malnutrition screening and diagnosis, in many settings malnutrition is often underdiagnosed and undertreated [ 12 , 14 ]. The majority of patients with or at risk of malnutrition reside in the community or residential aged care settings.…”

Section: Introductionmentioning

confidence: 99%

“…The Systematised, Interdisciplinary Malnutrition Program for impLementation and Evaluation (SIMPLE) and Integrated Nutrition Pathway for Acute Care (INPAC) provide two examples of such approaches [ 16 , 17 , 22 , 23 , 24 ]. However, in practice, a systematised approach to malnutrition care is not widely adopted, and low-value care remains commonplace [ 14 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Are Malnourished Inpatients Treated by Dietitians Active Participants in Their Nutrition Care? Findings of an Exploratory Study of Patient-Reported Measures across Nine Australian Hospitals

et al. 2023

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Background: Inpatient malnutrition is a key determinant of adverse patient and healthcare outcomes. The engagement of patients as active participants in nutrition care processes that support informed consent, care planning and shared decision making is recommended and has expected benefits. This study applied patient-reported measures to identify the proportion of malnourished inpatients seen by dietitians that reported engagement in key nutrition care processes. Methods: A subset analysis of a multisite malnutrition audit limited to patients with diagnosed malnutrition who had at least one dietitian chart entry and were able to respond to patient-reported measurement questions. Results: Data were available for 71 patients across nine Queensland hospitals. Patients were predominantly older adults (median 81 years, IQR 15) and female (n = 46) with mild/moderate (n = 50) versus severe (n = 17) or unspecified severity (n = 4) malnutrition. The median length of stay at the time of audit was 7 days (IQR 13). More than half of the patients included had two or more documented dietitian reviews. Nearly all patients (n = 68) received at least one form of nutrition support. A substantial number of patients reported not receiving a malnutrition diagnosis (n = 37), not being provided information about malnutrition (n = 30), or not having a plan for ongoing nutrition care or follow-up (n = 31). There were no clinically relevant trends between patient-reported measures and the number of dietitian reviews or severity of malnutrition. Conclusions: Malnourished inpatients seen by dietitians across multiple hospitals almost always receive nutritional support. Urgent attention is required to identify why these same patients do not routinely report receiving malnutrition diagnostic advice, receiving information about being at risk of malnutrition, and having a plan for ongoing nutrition care, regardless of how many times they are seen by dietitians.

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“…Nutritional status with all its aspects has been shown to be one of the most important factors impacting health in older adults. Malnutrition in particular is a highly prevalent condition in older age and carries high costs for individuals, families, and society due to its association with poor health, incapacitation, and adverse clinical outcomes such as frailty, osteoporosis, sarcopenia, and mortality [4]. Thus comprehensive assessment of nutritional status, besides screening for malnutrition, should be prioritized in the care of older adults.…”

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confidence: 99%

Nutrition and Older Adults – the Need for a More Comprehensive Approach

Medeiros de Morais

2023

Komp Nutr Diet

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Malnutrition in older adults

Cited by 82 publications

References 118 publications

Differentially Expressed Genes and Molecular Susceptibility to Human Age-Related Diseases

Differentially Expressed Genes and Molecular Susceptibility to Human Age-Related Diseases

Are Malnourished Inpatients Treated by Dietitians Active Participants in Their Nutrition Care? Findings of an Exploratory Study of Patient-Reported Measures across Nine Australian Hospitals

Nutrition and Older Adults – the Need for a More Comprehensive Approach

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