Malnourished mice display an impaired hematologic response to granulocyte colony-stimulating factor administration

Vinolo, Marco Aurélio Ramirez; Crisma, Amanda Rabello; Nakajima, Karina; Rogero, Marcelo Macedo; Fock, Ricardo Ambrósio; Borelli, Primavera

doi:10.1016/j.nutres.2008.08.006

Cited by 13 publications

(14 citation statements)

References 30 publications

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“…Protein deprivation also generated a decrease in the number of total BM granulocytes and erythroblasts. These results agree with previous studies that showed BM atrophy with a reduced number of leukocytes, granulocytes and lymphocytes [6], [31], [33].…”

Section: Discussionsupporting

confidence: 93%

Dietary Supplementation with Probiotics Improves Hematopoiesis in Malnourished Mice

et al. 2012

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Background Lactobacillus rhamnosus CRL1505 (Lr) administered during the repletion of immunocompromised-malnourished mice improves the resistance against intestinal and respiratory infections. This effect is associated with an increase in the number and functionality of immune cells, indicating that Lr could have some influence on myeloid and lymphoid cell production and maturation.ObjectiveThis study analyzed the extent of the damage caused by malnutrition on myeloid and lymphoid cell development in the spleen and bone marrow (BM). We also evaluated the impact of immunobiotics on the recovery of hematopoiesis affected in malnourished mice.MethodsProtein malnourished mice were fed on a balanced conventional diet for 7 or 14 consecutive d with or without supplemental Lr or fermented goat's milk (FGM). Malnourished mice and well-nourished mice were used as controls. Histological and flow cytometry studies were carried out in BM and spleen to study myeloid and lymphoid cells.ResultsMalnutrition induced quantitative alterations in spleen B and T cells; however, no alteration was observed in the ability of splenic B cells to produce immunoglobulins after challenge with LPS or CpG. The analysis of BM B cell subsets based on B220, CD24, IgM and IgD expression showed that malnutrition affected B cell development. In addition, BM myeloid cells decreased in malnourished mice. On the contrary, protein deprivation increased BM T cell number. These alterations were reverted with Lr or FGM repletion treatments since normal numbers of BM myeloid, T and B cells were observed in these groups.ConclusionsProtein malnutrition significantly alters B cell development in BM. The treatment of malnourished mice with L. rhamnosus CRL1505 was able to induce a recovery of B cells that would explain its ability to increase immunity against infections. This work highlights the possibility of using immunobiotics to accelerate the recovery of lymphopoyesis in immunocompromised-malnourished hosts.

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Section: Discussionsupporting

confidence: 93%

Dietary Supplementation with Probiotics Improves Hematopoiesis in Malnourished Mice

et al. 2012

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“…Based on previous literature results (Vinolo et al, 2008;Cunha et al, 2013;Oliveira et al, 2014) and with the current results, we can conclude that PM impacts GM-CSF production, leading to alterations in hematopoietic cell production and immune response. This pattern of cytokine production could partially explain immunodeficiency and the hematopoietic changes presented in proteinmalnourished organisms.…”

Section: Discussionsupporting

confidence: 86%

The influence of protein malnutrition on the production of GM-CSF and M-CSF by macrophages

Oliveira

Hastreiter

Borelli

et al. 2016

Braz. J. Pharm. Sci.

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“…● Protein-energy malnutrition (PEM) has its largest effect in reducing barrier function, both epithelial ( 47 – 52 ) and physiologic ( 53 – 55 ), followed by the function of macrophages ( 56 – 59 ), neutrophils ( 60 – 65 ), and to a lesser extent, NK cell activity ( 66 ).…”

Section: Part Ii: Wg Report Summariesmentioning

confidence: 99%

Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE)

Raiten¹,

Ashour²,

Ross

et al. 2015

The Journal of Nutrition

192

200

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An increasing recognition has emerged of the complexities of the global health agenda—specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1) the need for a better understanding of the bidirectional relations between nutritional status and the development and function of the immune and inflammatory response and 2) the specific impact of the inflammatory response on the selection, use, and interpretation of nutrient biomarkers. The goal of the Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE) is to provide guidance for those users represented by the global food and nutrition enterprise. These include researchers (bench and clinical), clinicians providing care/treatment, those developing and evaluating programs/interventions at scale, and those responsible for generating evidence-based policy. The INSPIRE process included convening 5 thematic working groups (WGs) charged with developing summary reports around the following issues: 1) basic overview of the interactions between nutrition, immune function, and the inflammatory response; 2) examination of the evidence regarding the impact of nutrition on immune function and inflammation; 3) evaluation of the impact of inflammation and clinical conditions (acute and chronic) on nutrition; 4) examination of existing and potential new approaches to account for the impact of inflammation on biomarker interpretation and use; and 5) the presentation of new approaches to the study of these relations. Each WG was tasked with synthesizing a summary of the evidence for each of these topics and delineating the remaining gaps in our knowledge. This review consists of a summary of the INSPIRE workshop and the WG deliberations.

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Malnourished mice display an impaired hematologic response to granulocyte colony-stimulating factor administration

Cited by 13 publications

References 30 publications

Dietary Supplementation with Probiotics Improves Hematopoiesis in Malnourished Mice

Dietary Supplementation with Probiotics Improves Hematopoiesis in Malnourished Mice

The influence of protein malnutrition on the production of GM-CSF and M-CSF by macrophages

Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE)

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