Malignant tumors of the uterine corpus: molecular background of their origin

Braný, Dušan; Dvorska, Dana; Ňachajová, Marcela; Slávik, Pavol; Burjanivová, Tatiana

doi:10.1007/s13277-015-3824-1

Cited by 7 publications

(7 citation statements)

References 64 publications

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“…The body of the uterus is composed of a mucosa muscular interface derived from the Müllerian embryonic ducts and constituted of internal endometrium and external myometrium (MM) tissue layers [ 1 , 2 , 3 , 4 ]. The internal endometrium is composed of luminal epithelium, glandular epithelium, and endometrial stroma whereas the MM consists mainly of smooth muscle cells [ 2 , 3 , 4 ]. Cellular and molecular alterations in the endometrial stroma and smooth muscle cell layers can lead to uterine sarcoma (US) development [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Features in Uterine Leiomyosarcoma and Endometrial Stromal Sarcomas: An Overview of the Literature

et al. 2022

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There is a consensus that epigenetic alterations play a key role in cancer initiation and its biology. Studies evaluating the modification in the DNA methylation and chromatin remodeling patterns, as well as gene regulation profile by non-coding RNAs (ncRNAs) have led to the development of novel therapeutic approaches to treat several tumor types. Indeed, despite clinical and translational challenges, combinatorial therapies employing agents targeting epigenetic modifications with conventional approaches have shown encouraging results. However, for rare neoplasia such as uterine leiomyosarcomas (LMS) and endometrial stromal sarcomas (ESS), treatment options are still limited. LMS has high chromosomal instability and molecular derangements, while ESS can present a specific gene fusion signature. Although they are the most frequent types of “pure” uterine sarcomas, these tumors are difficult to diagnose, have high rates of recurrence, and frequently develop resistance to current treatment options. The challenges involving the management of these tumors arise from the fact that the molecular mechanisms governing their progression have not been entirely elucidated. Hence, to fill this gap and highlight the importance of ongoing and future studies, we have cross-referenced the literature on uterine LMS and ESS and compiled the most relevant epigenetic studies, published between 2009 and 2022.

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Section: Introductionmentioning

confidence: 99%

Epigenetic Features in Uterine Leiomyosarcoma and Endometrial Stromal Sarcomas: An Overview of the Literature

et al. 2022

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Section: Introductionmentioning

confidence: 99%

“…Uterus cancer can be divided into two main groups, including endometrial and mesenchymal malignancies [ 14 ]. Endometrial cancers are common and mesenchymal malignancies are rare with a poorer prognosis [ 14 ]. Cervical cancer has decreased due to vaccination, screening, early detection and treatment of cervical dysplasia or pre-invasive cancers [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

The risk of distant metastases in patients with gynecologic cancers after surgery: a population-based study

Hsiao

Chen

Hsin

et al. 2021

Aging

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The aim of the study was to determine the risk of distant metastases in patients with gynecologic cancers after surgery, including cervical, uterine and ovarian cancers. This is a retrospective study evaluating gynecologic cancer from 2009 to 2014 using population-based administrative datasets from the Health and Welfare Data Science Center (HWDC) and from The National Health Informatics Project (NHIP). A total of 1,464 gynecologic cancer patients, including 321 cervical cancer patients, 724 uterine cancer patients and 419 ovarian cancer patients, were analyzed retrospectively from 2009 to 2014. Among the cervical cancer patients, 173 (53.89%) received surgery only and 148 (46.11%) received surgery with radiotherapy /chemotherapy. Among the uterus cancer patients, 425(58.70%) received surgery only and 299 (41.3%) received surgery with radiotherapy /chemotherapy. Among the ovarian cancer patients, 81 (19.33%) received surgery only and 338 (80.67%) received surgery with radiotherapy/chemotherapy. Among patients with brain, liver or lung metastasis, cervical cancer patients have more cumulative metastasis-free survival than those ovarian cancer (p=0.0041). In analyzing liver metastasis based on primary cancer sites, cervical cancer patients and uterine cancer cases have more cumulative metastasis- free survival than those ovarian cancer (p<0.0001). In conclusion, ovarian cancer patients have higher risk of liver metastasis than cervical or uterine cancer. There were significantly different of pathological stage for cumulative metastasis-free survival among gynecologic cancer patients with brain or liver or lung metastasis. Pathological T stage remains the main predictive for distant metastasis of gynecologic cancer.

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“…The former are common gynaecological diseases, whereas the latter manifest more aggressively and are rarer with worse prognosis than the former. Endometrioid adenocarcinomas and carcinosarcomas or leiomyosarcomas, considering clear types of tumours alone, are the most common types of endometrial tumours and mesenchymal tumours, respectively [1].…”

Section: Introductionmentioning

confidence: 99%

Mortality prediction in women with corpus uteri cancer in Brazil: a 21-year analysis

Dantas

Rodrigues

Gomes

et al. 2020

ecancer

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Mortality data obtained from the Mortality Information System identified a total of 19,499 deaths in women caused by corpus uteri cancer in Brazil. However, the association between mortality and sociodemographic factors in these women is not fully understood. A study based on the secondary data on deaths caused by corpus uteri cancer recorded in the SIM-DATASUS was conducted. Deaths reported from 1996 to 2016 in the health information system were included. Sociodemographic factors were analysed to determine their association with mortality. Low schooling is highly associated with mortality in all administrative regions. Advanced age, race and marital status have specific association with mortality for the different geographic regions. Black, Brown and Indigenous women with low schooling and of advanced age are highly associated with mortality. Brown, White and Black women of advanced age had the highest corpus uteri cancer related mortality rates. Women with low schooling who died of corpus uteri cancer were either single or widows. The marital status of Black, White and Brown women aged <59 years was single. The sociodemographic factors that predict mortality in women with corpus uteri cancer in Brazil were presented and can be used to guide public health.

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Malignant tumors of the uterine corpus: molecular background of their origin

Cited by 7 publications

References 64 publications

Epigenetic Features in Uterine Leiomyosarcoma and Endometrial Stromal Sarcomas: An Overview of the Literature

Epigenetic Features in Uterine Leiomyosarcoma and Endometrial Stromal Sarcomas: An Overview of the Literature

The risk of distant metastases in patients with gynecologic cancers after surgery: a population-based study

Mortality prediction in women with corpus uteri cancer in Brazil: a 21-year analysis

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