Malignant tumor of the trachea in children: diagnostic pitfalls and surgical management

Romão, Rodrigo Luiz Pinto; Barros, Fábio de; Filho, João Gilberto Maksoud; Gonçalves, Manoel Ernesto Peçanha; Cardoso, Sílvia Helena; Tannuri, Ana Cristina Aoun; Tannuri, Uenis

doi:10.1016/j.jpedsurg.2009.07.045

Cited by 14 publications

(22 citation statements)

References 13 publications

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“…It is important to note that, in contrast with earlier studies, most patients (n = 70; 90%) routinely underwent CT scans, which allows the early detection and better definition of small pulmonary lumps, consistent with the current algorithm for recurrent respiratory symptoms in pediatric populations …”

Section: Discussionmentioning

confidence: 63%

“…Diagnosis is often delayed because of nonspecific clinical presentations showing variable symptoms that are usually mistaken for respiratory tract infections or asthma …”

Section: Introductionmentioning

confidence: 99%

“…To date, most of the literature comprises case reports or case series that mainly focus on each histological subtype …”

Section: Introductionmentioning

confidence: 99%

“…2,3 Diagnosis is often delayed because of nonspecific clinical presentations showing variable symptoms that are usually mistaken for respiratory tract infections or asthma. 1,[4][5][6][7][8][9][10][11][12][13][14] Radical surgical resection seems to be the treatment of choice, whereas the endoscopic approach is recommended only in highly selected cases depending on histological type and tumor location. 13,15,16 Chemotherapy and radiotherapy are usually indicated only for the management of tumor relapse.…”

Section: Introductionmentioning

confidence: 99%

“…1,[4][5][6]8,10,17 To date, most of the literature comprises case reports or case series that mainly focus on each histological subtype. 3,[6][7][8][9][10][12][13][14][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Because specific pediatric oncologic guidelines on preoperative workup, treatment, and follow-up are still lacking, the International Network of Pediatric Airway Teams (INPAT) has coordinated a large international cohort of PTT in children, including the entire Italian cohort collected by the Tumori Rari in Età Pediatrica (TREP) (Rare Tumors in Children), with a total of 14 institutions to provide a complete overview with regard to clinical presentation, diagnostic assessment, histological findings, and outcomes. Particular attention has been given to identifying the main prognostic factors, possibly influencing outcome and carefully evaluating treatment modalities.…”

Section: Introductionmentioning

confidence: 99%

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Pediatric airway tumors: A report from the International Network of Pediatric Airway Teams (INPAT)

et al. 2019

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Objective Primary tracheobronchial tumors (PTTs) are rare heterogeneous lesions arising from any part of the tracheobronchial tree. Nonspecific symptoms may lead to delayed diagnosis that requires more aggressive surgical treatment. An analysis of cases collected by the International Network of Pediatric Airway Team was undertaken to ensure proper insight into the behavior and management of PTTs. Methods Patients <18 years of age with a histological confirmation of PTT diagnosed from 2000 to 2015 were included in this multicenter international retrospective study. Medical records, treatment modalities, and outcomes were analyzed. The patient presentation, tumor management, and clinical course were compared between malignant and benign histotypes. Clinical and surgical variables that might influence event‐free survival were considered. Results Among the 78 children identified, PTTs were more likely to be malignant than benign; bronchial carcinoid tumor (n = 31; 40%) was the most common histological subtype, followed by inflammatory myofibroblastic tumor (n = 19; 25%) and mucoepidermoid carcinoma (n = 15; 19%). Regarding symptoms at presentation, wheezing (P = 0.001) and dyspnea (P = 0.03) were more often associated with benign growth, whereas hemoptysis was more frequently associated with malignancy (P = 0.042). Factors that significantly worsened event‐free survival were age at diagnosis earlier than 112 months (P = 0.0035) and duration of symptoms lasting more than 2 months (P = 0.0029). Conclusion The results of this international study provide important information regarding the clinical presentation, diagnostic workup, and treatment of PTTs in children, casting new light on the biological behavior of PTTs to ensure appropriate treatments. Level of Evidence NA Laryngoscope, 130:E243–E251, 2020

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Section: Discussionmentioning

confidence: 63%

“…Diagnosis is often delayed because of nonspecific clinical presentations showing variable symptoms that are usually mistaken for respiratory tract infections or asthma …”

Section: Introductionmentioning

confidence: 99%

“…To date, most of the literature comprises case reports or case series that mainly focus on each histological subtype …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pediatric airway tumors: A report from the International Network of Pediatric Airway Teams (INPAT)

et al. 2019

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Unique application of awake tracheoscopy and endobronchial ultrasound in the management of tracheal mucoepidermoid carcinoma

et al. 2018

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Childhood and adolescent tracheobronchial mucoepidermoid carcinoma (MEC): a case-series and review of the literature

et al. 2016

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Tracheobronchial mucoepidermoid carcinomas (MEC) are rare in the pediatric population with literature limited primarily to case reports. Here we present our institutional experience treating MEC in three patients and review the literature of 142 pediatric cases previously published from 1968 to 2013. Although rare, tracheobronchial MEC should be included in the differential diagnosis in a child with recurrent respiratory symptoms. Conservative surgical management is often sufficient to achieve complete resection and good outcomes.

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Malignant tumor of the trachea in children: diagnostic pitfalls and surgical management

Cited by 14 publications

References 13 publications

Pediatric airway tumors: A report from the International Network of Pediatric Airway Teams (INPAT)

Pediatric airway tumors: A report from the International Network of Pediatric Airway Teams (INPAT)

Unique application of awake tracheoscopy and endobronchial ultrasound in the management of tracheal mucoepidermoid carcinoma

Childhood and adolescent tracheobronchial mucoepidermoid carcinoma (MEC): a case-series and review of the literature

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