Malignant Triton Tumor of the Ethmoid Sinus and Nasal Cavity

Nicolai, Piero; Tomenzoli, Davide; Berlucchi, Marco; Facchetti, Fabio; Morassi, L; Maroldi, Roberto

doi:10.1177/000348940010900918

Cited by 18 publications

(18 citation statements)

References 35 publications

(18 reference statements)

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“…This entity has been reported to occur within the sinonasal region. 10,14,19,22,28 Malignant Triton tumors commonly occur in the setting of type 1 neurofibromatosis. As indicated previously, none of the patients in this series had NF1.…”

Section: Discussionmentioning

confidence: 99%

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Low-grade Sinonasal Sarcoma With Neural and Myogenic Features

Lewis¹,

Oliveira²,

Nascimento

et al. 2012

American Journal of Surgical Pathology

133

196

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Sarcomas of the sinonasal region are rare. We describe a distinct spindle cell sarcoma of the sinonasal region characterized by concomitant neural and myogenic differentiation. Consultation files and surgical cases from Mayo Clinic were reviewed. Twenty-eight cases were identified that met the inclusion criteria. Clinical data were collected from medical records, consultation letters, and referring pathologists. Reverse transcriptase-polymerase chain reaction for synovial sarcoma fusion transcripts was performed on 18 cases. Cytogenetic studies were performed on 2 cases. The 21 female and 7 male patients ranged in age from 24 to 85 years (mean, 52 y). All cases showed a characteristic histology, which included a cellular spindle cell neoplasm with uniform, elongate nuclei and an infiltrative growth pattern. All tumors demonstrated expression of S-100 with actin positivity in 96% of cases tested. Reverse transcriptase-polymerase chain reaction for synovial sarcoma fusion transcripts was negative in all cases tested. Cytogenetic studies conducted on 2 cases demonstrated the chromosomal translocation t(2;4). The nasal cavity (54%) and ethmoid sinus (57%) were the most commonly involved areas, singly or in combination. Follow-up information was available for 57% (16/28) of cases, with a mean of 8.3 years. Of these, 44% (7/16) experienced at least 1 recurrence. No patient has developed metastases or died of disease. We describe a unique tumor with a characteristic morphologic, immunophenotypic, and cytogenetic profile. On the basis of the locally aggressive nature of this lesion we believe it is best considered a low-grade sarcoma and suggest the term low-grade sinonasal sarcoma with neural and myogenic features.

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Section: Discussionmentioning

confidence: 99%

“…After obtaining approval from the Mayo Clinic IRB, initial cases (22) were identified from the consultation files of the authors. Review of Mayo Clinic files of tumors previously diagnosed as sarcomas of the sinonasal region, including FS, MPNST, and synovial sarcoma, yielded 6 additional cases (initially diagnosed from 1956 to 1981).…”

Section: Methodsmentioning

confidence: 99%

Low-grade Sinonasal Sarcoma With Neural and Myogenic Features

Lewis¹,

Oliveira²,

Nascimento

et al. 2012

American Journal of Surgical Pathology

133

196

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“…Positive staining for S-100 in 50-90% percent of MTTs supports the presence of neurogenic elements of Schwannian origin [1]. A small subset of these lesions may have additional epithelial/mesenchymal elements, thus having "pluri-directional differentiation" [12]. Recently, due to the identification of a novel PAX3-NCOA1 fusion in BSNS, demonstration of PAX3 genetic abnormalities by FISH is proposed as an additional diagnostic tool in its identification [22].…”

Section: Pathologymentioning

confidence: 91%

“…Only two patients had died at the time of manuscript publication, one from an unrelated malignancy with no evidence of MTT recurrence, and the other a patient who had non-resectable tumor at initial presentation. All other patients were treated surgically, with eight receiving adjuvant radiotherapy and two adjuvant chemotherapy as summarized in Table 1 [6][7][8][9][10][11][12][13][14][15][16].…”

Section: Literature Reviewmentioning

confidence: 99%

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Sinonasal Malignant Triton Tumor: A Case Report with Historical and Surgical Review

Jl¹,

Sc²,

Kanthan³

2016

Head Neck Cancer Res

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International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

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Malignant Triton Tumor of the Ethmoid Sinus and Nasal Cavity

Cited by 18 publications

References 35 publications

Low-grade Sinonasal Sarcoma With Neural and Myogenic Features

Low-grade Sinonasal Sarcoma With Neural and Myogenic Features

Sinonasal Malignant Triton Tumor: A Case Report with Historical and Surgical Review

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

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