Malignant transformation of spinal meningeal melanocytoma

Wang, Fulin; Li, Xianghong; Gao, Xiang; Pu, Xiaolu

doi:10.3171/spi.2007.6.5.451

Cited by 55 publications

(28 citation statements)

References 11 publications

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“…Tumor to tumor metastases have been documented;[111314] however, there are only five cases reported concerning melanoma and all these reports emphasized on the existence of melanoma cells in the previously existed intracranial host tumor of different origin, which is different from our case. There were no melanoma cells found in the meningioma even though macroscopic appearance was black, which can mean that either the melanoma invaded intracranially and completely changed into meningioma or the meningioma had already existed when melanoma was diagnosed, but it was too small to be discovered from imaging studies.…”

Section: Discussioncontrasting

confidence: 70%

Cutaneous malignant melanoma "recurred as" or "in coexistence" with meningioma?

Rahmah

Horiuchi²,

Nakayama³

et al. 2010

Surg Neurol Int

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Background:The authors report a rare case of a patient with previously treated cutaneous malignant melanoma that recurred 1 year later as an intracranial meningioma.Case Description:A 20-year-old woman presented with exophthalmos, diplopia and a mass in the left supraorbital area. Imaging study revealed an enhanced intracranial extradural mass with bone destruction. The patient had a history of cutaneous malignant melanoma surgery on the same location 1 year before. The patient underwent left frontotemporal craniotomy for total resection of the mass. Histological study revealed the intracranial mass to be an atypical meningioma.Conclusion:To our knowledge, this is a rare report of a patient with this tumor occurrence. This case serves to remind neurosurgeons of the potential existence of benign and/ or malignant tumors of neural crest origin.

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Section: Discussioncontrasting

confidence: 70%

Cutaneous malignant melanoma "recurred as" or "in coexistence" with meningioma?

Rahmah

Horiuchi²,

Nakayama³

et al. 2010

Surg Neurol Int

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“…Some believe transition into malignant melanoma does not occur, however, we encountered to four cases of malignant transformation of meningeal melanocytoma, in the literature (10-13). We did not find any description for a case of melanocytoma with tonsillar hernaition; however, we presume that in a case with extensive meningeal involvement, an obstacle for complete debulking may increase the mass effect of the growing lesions consequently leading to this inevitable outcome.…”

Section: Discussionmentioning

confidence: 88%

Unusual Tonsillar Herniation in Meningeal Melanocytoma: A Case Report

et al. 2012

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Meningeal melanocytoma is a primary melanocytic neoplasm with certain MR and immunohistochemical characteristics worthy to note. In a 38-year-old man with a complaint of headache for a couple of years and recently added nausea, vomiting, diplopia, progressive visual blurring and hearing loss, magnetic resonance imaging (MRI) was remarkable for T1 shortening of leptomeninges and certain nodules in precontrast study. Subsequent contrast-enhanced MR imaging of the brain and spine revealed enhancement in the basal cisterns extending throughout the spinal canal. Contrast-enhanced MRI revealed diffuse enhancement in the basal cisterns extending throughout the spinal canal. Immunohistochemical analysis on one of the intraspinal nodules proposed leptomeningeal melanocytoma. The characteristic shortening of T1 and T2 relaxation times in MRI as a result of the paramagnetic stable free radicals that exist within melanin, often suggests a diagnosis of a melanocytic leptomeningeal process. Moreover, there are unique immunohistochemical characteristics for these varied lesions. In appropriate clinical settings, certain radiologic findings, especially both T1 and T2 shortening in nodular CNS lesions should propose meningeal melanocytoma.

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“…27 Malignant transformation of melanocytoma to malignant melanoma has been reported. [28][29][30][31] Meningeal melanocytomas are mass lesions and present with focal neurological signs associated with their location, intracranial hypertension or haemorrhage, neuropsychiatric symptoms, spinal cord compression, or seizures. 3,25,[32][33][34][35][36][37] They most commonly occur in the cervical and thoracic spine as intradural, extramedullary lesions.…”

Section: Meningeal Melanocytoma and Primary Cns Melanomamentioning

confidence: 99%