Malignant Transformation of Recurrent Respiratory Papillomatosis: Atypical Presentation as Right Mainstem Bronchus Occlusion

Siddiqi, Tauseef; Assar, Seth; Lougee, Kevin; Knepler, James

doi:10.1378/chest.1836553

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rare cases have been identified in patients with HPV papillomatosis. [2][3][4][5][6][7][8][9][10] When malignant transformation occurs, there is usually a latent period of more than 15 years from initial diagnosis. [11] Also, these patients initially demonstrate recurrent respiratory papillomatosis prior to two and a half years of age and require frequent papilloma debulking and tracheostomy.…”

Section: Introductionmentioning

confidence: 99%

Hypercalcemia with invasive pulmonary papillomatosis and microinvasive squamous carcinoma

Oertling¹,

Daroca²,

Hartz³

et al. 2020

CRCP

View full text Add to dashboard Cite

Juvenile respiratory papillomatosis is a rare pediatric disease in which benign papillomata develop in the respiratory tract, most commonly involving the larynx and tracheobronchial tree. Invasive pulmonary papillomatosis is an aggressive form in which the papillomata extend into the lung parenchyma. We report a case of a 22-year-old man with a long-standing juvenile respiratory tract papillomatosis, initially diagnosed at age 2, who subsequently developed invasive pulmonary papillomatosis and underwent partial surgical resection for his pulmonary disease. Hypercalcemia complicated the patient’s final hospitalizations. HPV typing performed on a laryngeal papilloma was positive for HPV 6/11. The lobectomy specimen revealed malignant transformation of invasive pulmonary papillomatosis characterized by the presence of microinvasive nests of squamous carcinoma. Immunohistochemical stain for parathyroid hormone on the invasive component was negative. Eventually, the patient succumbed to his disease and while the family refused post-mortem examination, Positron Emission Tomography (PET) performed during the patient’s terminal course suggested the possibility of metastasis to liver and periaortic lymph nodes. There was no evidence of bony metastasis.

show abstract