Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases

Stoot, Jan H.M.B.; Coelen, Robert J.S.; Jong, Mechteld C. de; Dejong, Cornelis H. C.

doi:10.1111/j.1477-2574.2010.00222.x

Cited by 298 publications

(265 citation statements)

References 157 publications

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“…2,3,5,25 In our transplanted patients' group, lesions involved the liver in multiple sites showing smaller average diameters. A standardized nomenclature was first proposed in 1994, placing FNH in the group of regenerative nodules, as opposed to dysplastic or neoplastic nodules.…”

Section: Resultsmentioning

confidence: 99%

Focal nodular hyperplasia of the liver: an emerging complication of hematopoietic SCT in children

Pillon

Carucci

Mainardi

et al. 2015

Bone Marrow Transplant

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Hepatic focal nodular hyperplasia (FNH) is a nonmalignant condition rarely affecting children previously treated for cancer, especially those who received hematopoietic SCT (HSCT). Some aspects of its pathogenesis still remain unclear and a strong association with specific risk factors has not yet been identified. We report here a single institution's case series of 17 patients who underwent HSCT and were diagnosed with FNH, analyzing retrospectively their clinical features and the radiological appearance of their hepatic lesions. We aimed to compare the diagnostic accuracy of ultrasound (US) and magnetic resonance imaging (MRI) and to explore the role of transient elastography (FibroScan) to evaluate the degree of hepatic fibrosis in FNH patients. Our analysis showed an association of FNH with age at transplant ⩽ 12 years (hazard ratio (HR) 9.10); chronic GVHD (HR 2.99); hormonereplacement therapy (HR 4.02) and abdominal radiotherapy (HR 4.37). MRI proved to be a more accurate diagnostic tool compared with US. Nine out of 12 patients who underwent FibroScan showed hepatic fibrosis. Our study points out that FNH is an emerging complication of HSCT, which requires a lifelong surveillance to follow its course in cancer patients.

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Section: Resultsmentioning

confidence: 99%

Focal nodular hyperplasia of the liver: an emerging complication of hematopoietic SCT in children

Pillon

Carucci

Mainardi

et al. 2015

Bone Marrow Transplant

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“…9,10 Although HCAs are benign, lesions larger than 5 cm have a relatively high risk of bleeding (25-40%) and an estimated risk of malignant transformation of approximately 5 per cent. [11][12][13] For these lesions elective resection is generally accepted as treatment of choice and can be performed both through an open or laparoscopic approach.…”

Section: Introductionmentioning

confidence: 99%

Long-term outcomes of resection in patients with symptomatic benign liver tumours

Rosmalen

Bieze

Besselink

et al. 2016

HPB

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“…Malignant transformation of hca into hcc is a rare phenomenon, occurring with reported frequency of 4.2%. In a review of the available literature of hca in 2010, Stoot et al 9 identified 19 cases of malignant transformation of hca, of which only 5 occurred in men.…”

Section: Discussionmentioning

confidence: 99%

“…Hepatocellular adenomas are uncommon benign tumours of the liver that typically occur in women taking oral contraceptive pills 9 . Malignant transformation of hca into hcc is a rare phenomenon, occurring with reported frequency of 4.2%.…”

Section: Discussionmentioning

confidence: 99%

Extrahepatic Metastasis of Hepatocellular Carcinoma Arising from a Hepatic Adenoma without Concurrent Intrahepatic Recurrence

et al. 2017

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Hepatocellular carcinoma (hcc) arising from a hepatic adenoma is a rare phenomenon accounting for fewer than 5% of hcc cases; it seldom recurs after resection of the primary tumour. We report a case of extrahepatic metastasis of hcc arising from a hepatic adenoma that presented as a solitary sternal metastasis without any evidence of intrahepatic recurrence.Our patient was initially treated with radiation therapy and bland embolization, without response. Subsequently, the patient developed progressive disease while taking sorafenib. He later received chemotherapy with docetaxel and gemcitabine, with the development of multiple pulmonary and splenic nodules. However, he remained free of intrahepatic recurrence. To the best of our knowledge, this is the first case of extrahepatic metastasis of hcc arising from a hepatic adenoma without evidence of intrahepatic recurrence.

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Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases

Cited by 298 publications

References 157 publications

Focal nodular hyperplasia of the liver: an emerging complication of hematopoietic SCT in children

Focal nodular hyperplasia of the liver: an emerging complication of hematopoietic SCT in children

Long-term outcomes of resection in patients with symptomatic benign liver tumours

Extrahepatic Metastasis of Hepatocellular Carcinoma Arising from a Hepatic Adenoma without Concurrent Intrahepatic Recurrence

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