Malignant transformation of biliary cystadenoma: a difficult diagnosis

Poggio, P. Del; Jamoletti, Carlo; Forloni, B; Benedictis, Raffaele De; Mattiello, M.; Corti, D.; Pezzica, E

doi:10.1016/s1590-8658(00)80339-4

Cited by 21 publications

(31 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Intracystic hemorrhage and fine punctuate calcifications may present in both conditions and can also be observed in complicated hemorrhagic cysts, their role as diagnostic criterion are, therefore, doubtful [5] . Fine needle aspiration can be used to differentiate a biliary cyst from other benign conditions and from a single metastasis, but is totally unreliable in differentiating cystadenoma from cystadenocarcinoma, since small neoplastic foci are undetectable by fine needle aspiration and may be revealed only in the surgical specimen [6] .…”

Section: Solitary Cystic Tumorsmentioning

confidence: 99%

Cystic tumors of the liver: A practical approach

Poggio¹,

Buonocore²

2008

WJG

113

110

View full text Add to dashboard Cite

Biliary cyst tumors (cystadenoma and cystadenocarcinoma) are an indication for liver resection. They account for only 5% of all solitary cystic lesions of the liver, but differential diagnosis with multiloculated or complicated biliary cysts, atypical hemangiomas, hamartomas and lymphangiomas may be difficult. The most frequent challenge is to differentiate biliary cyst tumors from hemorrhagic cysts. Computerized tomography (CT) and magnetic resonance imaging (MRI) are often not diagnostic and in these cases fine needle aspiration (FNA) is used to confirm the presence of atypical biliary cells. FNA, however, lacks adequate sensitivity and specificity and should always be used in conjunction with imaging. Pre-operative differentiation o f c y s t a d e n o m a f r o m c y s t a d e n o c a r c i n o m a i s impossible and surgery must be performed if a biliary cyst tumor is suspected. When multiple cystic lesions are observed throughout the liver parenchyma, it is important to exclude liver metastasis, of which colonic cancer is the most common primary site. Multiple biliary hamartomas (von Meyenburg complex) can appear as a mixture of solid and cystic lesions and can be confused with cystic metastasis. Strong and uniform T2 hyperintensity on MRI is usually diagnostic, but occasionally a percutaneous biopsy may be required.

show abstract

Section: Solitary Cystic Tumorsmentioning

confidence: 99%

Cystic tumors of the liver: A practical approach

Poggio¹,

Buonocore²

2008

WJG

113

110

View full text Add to dashboard Cite

show abstract

“…En effet, vu la difficulté de distinguer sur le plan macroscopique le cystadénome du cystadénocarcinome, les précautions carcinologiques doivent être toujours de mise. Pour cette même raison, les gestes de ponction biopsie et aspiration doivent être évités et ce d'autant plus que leur intérêt diagnostique reste faible [8,9,11].…”

Section: Discussionunclassified

Cystadénome hépatique: le besoin d’un traitement radical

et al. 2010

View full text Add to dashboard Cite

Le cystadénome hépatique est une tumeur rare, touchant souvent la femme. Il se caractérise par sa tendance à récidiver après chirurgie et son risque de transformation maligne en cystadénocarcinome. Seul l'examen anatomopathologique peut trancher sur la nature bénigne ou maligne de la lésion. Nous rapportons le cas d'un cystadénome mucineux à stroma mésenchymateux et nous discutons les aspects diagnostiques et thérapeutiques de ce type de lésion qui justifie un traitement chirurgical radical, même en absence d'arguments en faveur de la malignité. Mots clés Cystadénome hépatique · Cystadénocarcinome · HépatectomieAbstract The hepatic cystadenoma is a rare tumor, often affecting women. It is characterized by its tendency to recur after surgery and the risk of malignant transformation into cystadenocarcinoma. Only histological examination can decide on the benign or malignant lesion. We report the case of a mucinous cystadenoma with mesenchymal stroma, and we discuss the diagnosis and therapeutic aspects of this type of lesion that justify a radical surgical treatment, even in the absence of arguments in favor of malignancy.

show abstract

“…Ряд авторов отмечают, что ЦАК в большей степени соответствуют злокачественно перерожденным ЦА, так как в описанных наблюдениях основные участки тяжелой дисплазии в стенке ЦАК были выявлены в некоторых еще неперерожденных ЦА [33,86]. Высказывается мнение о том, что злокачественная трансформация развивается не менее чем через 20 лет после возникновения билиарной ЦА [21].…”

Section: этиопатогенез и молекулярная биология кистозных заболеваний unclassified

“…Так как кистозный компонент иногда может выявляться в более распространенных пер-вичных злокачественных опухолях, например при гепато-целлюлярном и холангиоцеллюлярном раке, эти нозоло-гии могут имитировать гепатобилиарную ЦАК [55]. При оценке данных МСКТ и МРТ с внутривенным контраст-ным усилением эти заболевания можно будет исключить [33].…”

Section: дифференциальная диагностика кистозных опухолей печениunclassified

“…При проведении допплеровского сканирования определяется наличие кровотока во внутренних перегородках, что может озна-чать наличие первичной ЦА или злокачественной транс-формации в ЦАК, безусловно, требующее дальнейшего дифференциального поиска [33].…”

unclassified

See 1 more Smart Citation