Malignant transformation of an abdominal inflammatory myofibroblastic tumor with distant metastases in a child

Ernst, Caroline; Bosch, Jutte van der Werff ten; Desprechins, Brigitte; Mey, Johan De; Maeseneer, Michel De

doi:10.5334/jbr-btr.500

Cited by 8 publications

(13 citation statements)

References 15 publications

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“…Due to the rarity of IMTs, only a few cases have been reported in the literature to date (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), and the incidence rates remain unclear. IMTs are most prevalent in the pulmonary system of children and young adults, however, they may also develop in older patients and in other organs (18).…”

Section: Introductionmentioning

confidence: 99%

“…IMTs are most commonly diagnosed via ultrasound, abdominal computed tomography (CT) or magnetic resonance imaging (18). Radical resection is the treatment of choice for patients with IMT (2). Prognostic factors for the disease remain unclear, however, survival is good in the majority of patients, with a five-year survival rate of ~87% (4).…”

Section: Introductionmentioning

confidence: 99%

“…Inflammatory myofibroblastic tumors (IMTs), originally termed as inflammatory pseudotumors, are rare neoplastic lesions with a tendency for locally aggressive behavior and recurrence (1,2). Due to the rarity of IMTs, only a few cases have been reported in the literature to date (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), and the incidence rates remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…However, a few studies have reported certain benefits in the treatment of invasive or incompletely resected IMT using immunosuppressive therapy with corticosteroids and non-steroidal inflammatory agents (10,15), radiation therapy (16) and chemotherapy (2,5,16). In the aggressive forms of IMT, exhibiting a high local recurrence rate and a potential for metastasis, it is recommended that close follow-up consisting of physical examination, radiographic imaging and the evaluation of serial erythrocyte sedimentation rates is undertaken (15).…”

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confidence: 99%

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Multiple malignant inflammatory myofibroblastic tumors of the jejunum: A case report and literature review

et al. 2015

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Abstract. Inflammatory myofibroblastic tumors (IMTs) are rare neoplastic lesions with a tendency for locally aggressive behavior and recurrence. IMTs most frequently occur in the soft tissues of children and young adults, with the lungs being the most commonly affected site; however, it has been recognized that any anatomical location may be involved. IMT in the jejunum is extremely rare, with only one case previously reported in the literature. The current study describes the case of a 42-year-old woman presenting with intermittent abdominal pain and small bowel intussusception that was identified during a laparotomy. Surgical resection of the jejunum, revealing 3 exophytic tumors, provided specimens for analysis. Following histological examination, a diagnosis of IMT was made. A review of the literature regarding this rare disease is also presented to emphasize the risk of local recurrence and the importance of adequate long-term follow-up.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Multiple malignant inflammatory myofibroblastic tumors of the jejunum: A case report and literature review

et al. 2015

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“…Recurrence rates are related to body site, multifocality and completeness of resection (12)(13)(14)(15)(16)(17). Rare malignant transformation has been reported (18,19). It is rare for IMT to occur in the breast, and only 19 cases have been reported in the English literature (20)(21)(22)(23)(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report

Zhao¹,

Wang

et al. 2012

Oncology Letters

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Abstract. Primary inflammatory myofibroblastic tumor (IMT) of the breast is extremely rare; only 19 cases have been reported in the English literature. In the present study, we present a case of IMT in a 56-year-old female patient who was admitted to our hospital due to a mass found in her right breast. Mammogram and ultrasound revealed a well-circumscribed mass and surgery was performed. Histopathologically, the lesion was composed of spindle and inflammatory cells, including plasma cells and lymphocytes. Mitotic figures were not observed. Immunohistochemically, the tumor cells were positive for SM-actin, anaplastic lymphoma kinase (ALK) and vimentin and focal positive for desmin, but negative for NSE, S-100, CD117, CD34, NF, CD21, CD35 and CD68. Thus, we made a diagnosis of IMT and advised regular follow-up. However, the patient had local recurrence and metastasis to the left groin area 3, 7 and 10 months after the initial surgery. Notably, the histopathological characteristics of the recurrent and metastatic foci were similar to those of the initial specimen, but mitotic figures were clearly observed. Thus, we conclude that IMT shows occasionally malignant biological behavior although it is a neoplasm of intermediate biological potential that frequently recurs and rarely metastasizes. We advise that clinical physicians should regularly follow up patients after focal resection for IMT.

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Inflammatory myofibroblastic tumor of the esophagus treated by endoscopy

et al. 2012

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Inflammatory myofibroblastic tumors are rare lesions that have been described in virtually every organ including the gastrointestinal tract. The esophagus is an extremely unusual site for these tumors, with only a few cases described in the literature. Surgery has been the most common therapeutic approach used for the resection of these lesions. In the present case, a patient diagnosed with an inflammatory myofibroblastic tumor of the upper esophagus was reported, and it was successfully removed by endoscopy with no complications.

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Malignant transformation of an abdominal inflammatory myofibroblastic tumor with distant metastases in a child

Cited by 8 publications

References 15 publications

Multiple malignant inflammatory myofibroblastic tumors of the jejunum: A case report and literature review

Multiple malignant inflammatory myofibroblastic tumors of the jejunum: A case report and literature review

Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report

Inflammatory myofibroblastic tumor of the esophagus treated by endoscopy

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