Malignant transformation of a non-healing traumatic wound on the lower extremity: A case report

Day, Deborah-Leigh; Chakari, Wahida; Matzen, Steen Henrik

doi:10.1016/j.ijscr.2018.11.026

Cited by 5 publications

(3 citation statements)

References 13 publications

(17 reference statements)

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“…7 Marjolin's Ulcer is a rare complication which has been observed in scar tissue, chronic ulcers, osteomyelitis, fistulas and any wound aggravated by persistent inflammation. 11,12,17,19 The pathophysiology of chronic wounds undergoing malignant transformation has been debated over the past century and no specific factor has been identified. 15 Prevailing theories suggest repetitive tissue damage leading to cellular proliferation, prone to spontaneous mutations.…”

Section: Discussionmentioning

confidence: 99%

Marjolin's Tumor Complicating Chronic Periprosthetic Infection of a Total Knee Arthroplasty

Horan

Wallace

Aboulafia

et al. 2019

J. Bone Joint Infect.

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Abstract. Marjolin's tumor is a term used to describe a malignancy developing in the setting of a chronic wound, infection, or other tissue subject to chronic inflammatory changes. These malignancies usually present after many years of chronicity, and can range from lower grade basal cell carcinomas to high-grade sarcomas. We present the case of a squamous cell carcinoma that developed within a chronic periprosthetic infection of a total knee arthroplasty of 7 years duration. The intra-articular location, association with an orthopaedic implant, and brief latency period are all unique features of this case.

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Section: Discussionmentioning

confidence: 99%

Marjolin's Tumor Complicating Chronic Periprosthetic Infection of a Total Knee Arthroplasty

Horan

Wallace

Aboulafia

et al. 2019

J. Bone Joint Infect.

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“…Macrophages participate in all these stages and follow a transition of phenotypes from inflammatory to homeostatic as the healing progresses. If there is any dysregulation in macrophage function and phenotype transition, it messes up the healing or fibrosis and leads to pathological conditions, e.g., lung scarring, and chronic no-healing wounds can lead to cancer [ 130 ]. Tissue-resident macrophages (TRMs) originate from the yolk sac and fetal liver during embryonic development and persist in many tissues via self-renewal [ 131 ].…”

Section: Macrophage Phenotypesmentioning

confidence: 99%

Macrophage subsets and their role: co-relation with colony-stimulating factor-1 receptor and clinical relevance

et al. 2022

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Macrophages are one of the first innate immune cells to reach the site of infection or injury. Diverse functions from the uptake of pathogen or antigen, its killing, and presentation, the release of pro- or anti-inflammatory cytokines, activation of adaptive immune cells, clearing off tissue debris, tissue repair, and maintenance of tissue homeostasis have been attributed to macrophages. Besides tissue-resident macrophages, the circulating macrophages are recruited to different tissues to get activated. These are highly plastic cells, showing a spectrum of phenotypes depending on the stimulus received from their immediate environment. The macrophage differentiation requires colony-stimulating factor-1 (CSF-1) or macrophage colony-stimulating factor (M-CSF), colony-stimulating factor-2 (CSF-2), or granulocyte–macrophage colony-stimulating factor (GM-CSF) and different stimuli activate them to different phenotypes. The richness of tissue macrophages is precisely controlled via the CSF-1 and CSF-1R axis. In this review, we have given an overview of macrophage origin via hematopoiesis/myelopoiesis, different phenotypes associated with macrophages, their clinical significance, and how they are altered in various diseases. We have specifically focused on the function of CSF-1/CSF-1R signaling in deciding macrophage fate and the outcome of aberrant CSF-1R signaling in relation to macrophage phenotype in different diseases. We further extend the review to briefly discuss the possible strategies to manipulate CSF-1R and its signaling with the recent updates. Graphical Abstract

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“…2,5 . La base de la fisiopatología de la formación de esta úlcera se debe principalmente a la existencia de un ambiente inflamatorio crónico, la presencia de células con alta capacidad mitótica, pobre drenaje linfático, tejidos isquémicos y abundantes productos citotóxicos derivados de la actividad inmunitaria constante 1,6,7 .…”

Section: Introductionunclassified

ÓÓlcera de Marjolin, escenario final en la evoluciÓ³n de una Óºlcera venosa crÓ³nica

Segura-Marín¹,

Segura-Feria²,

López-Ramos³

et al. 2022

RMA

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La úlcera de Marjolin se define como una neoplasia desarrollada en el seno de una herida que ha sido crónicamente traumatizada. Presentamos el caso de una úlcera venosa crónica con degeneración maligna y realizamos una breve revisión de la literatura. Se trata de una paciente de género femenino, de 50 años de edad, con enfermedad venosa crónica diagnosticada desde los 20 años. Se le realizó ablación farmacológica de vena safena mayor bilateral; dos décadas mas tarde desarrolló una úlcera varicosa en cara medial de pierna derecha presentando recidiva a pesar de tratamiento durante 10 años. Esta úlcera aumentó de tamaño y presentó sangrado, por lo que se decide realizar biopsias. El reporte histopatológico reveló degeneración neoplásica maligna con extensión a planos profundos y adenopatías inguinales. Se realizó amputación supracondílea del miembro pélvico derecho con linfadenectomía inguinal. En conclusión, la úlcera de Marjolin secundaria a una úlcera varicosa puede tener mayor morbilidad debido a su localización, ya que predomina en las extremidades y generalmente es identificada en estadios avanzados, pudiendo conducir a desenlaces sombríos.

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Malignant transformation of a non-healing traumatic wound on the lower extremity: A case report

Cited by 5 publications

References 13 publications

Marjolin's Tumor Complicating Chronic Periprosthetic Infection of a Total Knee Arthroplasty

Marjolin's Tumor Complicating Chronic Periprosthetic Infection of a Total Knee Arthroplasty

Macrophage subsets and their role: co-relation with colony-stimulating factor-1 receptor and clinical relevance

ÓÓlcera de Marjolin, escenario final en la evoluciÓ³n de una Óºlcera venosa crÓ³nica

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