Malignant Transformation of a Neurenteric Cyst in the Posterior Fossa Presenting with Intracranial Metastasis: A Case Report and Literature Review

Fujisawa, Naoaki; Oya, Soichi; Higashi, Morihiro; Matsui, Toru

doi:10.2176/nmccrj.cr.2014-0416

Cited by 12 publications

(17 citation statements)

References 19 publications

(27 reference statements)

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“…DWI was negative in all patients (100%), and T1 contrast-enhanced imaging demonstrated minimal rim enhancement in two patients (25%) (►Figs. [1][2][3][4][5].…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, several other mechanisms may also lead to the development of these cysts, including failure of disjunction between the notochord and mesoderm at escalation, ectopic endodermal nests of cells, and abnormal splitting of the notochord that may lead to adhesions of undifferentiated gastrointestinal or respiratory cells in ectodermal layers. [2][3][4][5] These cysts commonly arise in the lower cervical spine and upper thoracic spine and can be associated with other anomalies in the spine as well. Sinus tracts are not a common finding with these lesions, even with the proposed mechanism of embryological nondisjunction.…”

Section: Introductionmentioning

confidence: 99%

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Surgical Experience and Management of Intracranial Neurenteric Cysts: Single-Center Experience and Review of the Literature

Yagnik

Vakharia

Vaubel

et al. 2022

J Neurol Surg B Skull Base

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Background: Neurenteric cysts (NEC) are rare, congenital lesions lined by endodermal cell-derived columnar or cuboidal epithelium. Based upon previous studies, gross total removal of the capsule has been presumed to be the ideal surgical goal. Objective: This series was undertaken to further understand the risk of recurrence based on extent of capsule resection. Methods: Records were retrospectively reviewed for all patients with radiographic or pathological evidence of intracranial neurenteric cyst from 1996 to 2021. Results: A total of 8 patients were identified; Four of 8 (50%) presented with headache, four had signs of one or more cranial nerve syndromes. One patient (13%) presented with 3rd nerve palsy, one (13%) had 6th nerve palsy, and two (25%) with hemifacial spasm. One patient (13%) presented with signs of obstructive hydrocephalus. MRI demonstrated T2 hyper- or iso-intense lesions. Diffusion-weighted imaging was negative in all patients (100%) and T1 contrast-enhanced imaging demonstrated minimal rim enhancement in two patients (25%). In 3 of 8 (38%), a gross total resection (GTR) was achieved; while in 4 (50%) a near-total resection, and in one (13%) a decompression was performed. Recurrences occurred in 2 (25%) patients, one with decompression and another with near-total resection, among these ½ required repeat surgery after a mean follow-up of 77 months. Conclusion: In this series, none from GTR group demonstrated recurrence, while 40% of those receiving a less than gross total resection recurred, underpinning the importance of maximally safe resection in these patients. Overall patients did well without major morbidity from surgery.

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“…DWI was negative in all patients (100%), and T1 contrast-enhanced imaging demonstrated minimal rim enhancement in two patients (25%) (►Figs. [1][2][3][4][5].…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surgical Experience and Management of Intracranial Neurenteric Cysts: Single-Center Experience and Review of the Literature

Yagnik

Vakharia

Vaubel

et al. 2022

J Neurol Surg B Skull Base

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“…In immunohistochemistry, they are positive for cytokeratin, epithelial membrane antigen, and carcinoembryonic antigen. Degeneration to adenocarcinoma is extremely unusual and only occurs in intracranial locations (9 patients reported) [27]. In these cases, carbohydrate antigen 19-9 (CA 19-9) is positive [26], elevated MIB-1 labeling index suggests malignancy [27].…”

Section: Case Discussionmentioning

confidence: 99%

“…Degeneration to adenocarcinoma is extremely unusual and only occurs in intracranial locations (9 patients reported) [27]. In these cases, carbohydrate antigen 19-9 (CA 19-9) is positive [26], elevated MIB-1 labeling index suggests malignancy [27]. No correlation between imaging findings and pathology has been found [35].…”

Section: Case Discussionmentioning

confidence: 99%

“…Neuroenteric cysts (NEC) are rare benign (the malignant transformation is extremely rare) lesions of the spinal axis composed of heterotopic endodermal Rare Brain Tumors with Infrequent Clinical Manifestations: Illustrative Cases DOI: http://dx.doi.org/10.5772/intechopen.101062 tissue generally located in the intradural extramedullary space in the lower cervical and upper thoracic spine, comprising 0.03% of intracranial lesions and 16% of cystic lesions of the CNS, they can found rarely intracranially, examples in the posterior fossa are ventral to the brainstem or in the cerebellopontine angle, and they present with hydrocephalus, headache, and cranial nerve deficits [26,27]. The origin of these lesions is not completely understood, histologically are composed of cuboidal epithelium that resembles the gastrointestinal or respiratory tract.…”

Section: Neuroenteric Cyst On Posterior Fossa Associated With Klippel-feil Syndromementioning

confidence: 99%

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Rare Brain Tumors with Infrequent Clinical Manifestations: Illustrative Cases

Navarro-Olvera¹,

Armas-Salazar²,

Carrillo-Ruíz³

et al. 2022

Brain Tumors

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This chapter describes the epidemiology, clinical and neuroimaging features, histological characteristics, surgical approach, outcomes, and prognostic factors of different cases of very rare intracranial tumors, associated with complex clinical syndromes. Highlighting the important aspects in the diagnosis and management that were considered relevant through the experience of our center. Here we included an intracranial Rosai-Dorfman disease manifested as an apparent multiple meningiomatosis, a choroid plexus papilloma clinically manifested as a hemifacial spasm originated by a compression of the facial colliculus, and a neuroenteric cyst associated with Klippel-Feil syndrome. This type of tumor presents a challenge to the neurosurgeon, originating various questions about its management. In this chapter, we present the experience we had with these pathologies to establish the most appropriate management decisions.

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Pediatric intracranial neurenteric cyst of the oculomotor nerve: a case-based review

et al. 2021

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Malignant Transformation of a Neurenteric Cyst in the Posterior Fossa Presenting with Intracranial Metastasis: A Case Report and Literature Review

Cited by 12 publications

References 19 publications

Surgical Experience and Management of Intracranial Neurenteric Cysts: Single-Center Experience and Review of the Literature

Surgical Experience and Management of Intracranial Neurenteric Cysts: Single-Center Experience and Review of the Literature

Rare Brain Tumors with Infrequent Clinical Manifestations: Illustrative Cases

Pediatric intracranial neurenteric cyst of the oculomotor nerve: a case-based review

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