Malignant Transformation in a Young Adult With Recurrent Laryngeal Papillomatosis

Behl, Arun; James, Eddie A.; Kelkar, Prasad; Chawla, Naveen

doi:10.1016/s0377-1237(01)80140-4

Cited by 2 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Scarring secondary of repeated surgical treatment for RRP is common and should be identified and prevented whenever possible (12). Additionally, malignant transformation of juvenile-onset RRP has been observed in young adults and in rare cases in children, causing a worse outcome (13,14). As with our patient, dysplasia can be identified in up to 50% of RRP cases, requiring a regular histological control, as envisaged in our case.…”

Section: F O R P U B L I C a T I O Nsupporting

confidence: 58%

Juvenile laryngeal papillomatosis: a rare cause of upper airway obstruction with possible dysplasia

Sidatt¹,

Lehbib²,

Lemine³

et al. 2023

Pediatr Respir J

View full text Add to dashboard Cite

Laryngeal papillomatosis is a rare and potentially severe cause of recurrent laryngeal dyspnea resistant to the usual treatments. It results from human papilloma virus (HPV) infection, transmitted M a n u s c r i p t a c c e p t e d f o r p u b l i c a t i o n during the perinatal period, and is mainly observed during the childhood. Upper airway obstruction is due to the growth of benign tumor, with rare malignant transformation. However, genetic mutation in association with viral integration can lead to the development and clonal expansion of malignant lesions. We report on one pediatric case of recurrent upper airway obstruction due to severe laryngeal papillomatosis with histological dysplasia. Through this case, the Authors emphasize the importance of early detection, close follow up, and appropriate treatment. They also call for increased HPV immunization coverage in low-income countries where medical resources are limited.IMPACT STATEMENT: Juvenile laryngeal papillomatosis is a rare but serious recurrent respiratory emergency with possible malignant transformation. Its management is challenging in low-income countries, and the HPV immunization is a promising measure.

show abstract

Section: F O R P U B L I C a T I O Nsupporting

confidence: 58%

Juvenile laryngeal papillomatosis: a rare cause of upper airway obstruction with possible dysplasia

Sidatt¹,

Lehbib²,

Lemine³

et al. 2023

Pediatr Respir J

View full text Add to dashboard Cite

show abstract

Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature

El‐Achkar

Duarte

Saggioro

et al. 2018

Case Reports in Otolaryngology

View full text Add to dashboard Cite

Background The malignant transformation of laryngeal papillomatosis (LP) into squamous cell carcinoma (SCC) can occur in up to 4% of LP cases. The low-risk HPV types 6 and 11 are those that are most commonly related to LP; however, high-risk HPV types may be present. The present study reviews the literature on cases of malignant transformation of LP in adults and reports a clinical case. Case Report A 47-year-old male patient exhibiting hoarseness for 4 months presented an exophytic lesion in the right palatine tonsil and a digitiform-like lesion in the right vocal fold. The biopsy revealed a well-differentiated SCC in the vocal cord, which showed a transition zone with a squamous papillomatous lesion. By using the chromogenic in situ hybridization (CISH) test, both lesions showed a positive result for high-risk HPV types 16 and 18 and negative for low-risk HPV types 6 and 11. The final diagnosis was SCC arising from LP. The patient underwent surgical treatment. After 36 months of follow-up, no signs of recurrence were observed. Results The literature review revealed 25 cases of malignant transformation into SCC of LP with adult onset. Of these, only 9 cases were assessed by CISH and/or PCR for HPV identification, of which 7 were positive. The current study focuses on the eighth case, suggesting the involvement of the high-risk HPV types in its pathogenesis. Conclusions LP is considered a benign lesion with the potential for malignant transformation, which reinforces the need for its early diagnosis and the constant monitoring of patients with LP.

show abstract

Malignant Transformation in a Young Adult With Recurrent Laryngeal Papillomatosis

Cited by 2 publications

References 8 publications

Juvenile laryngeal papillomatosis: a rare cause of upper airway obstruction with possible dysplasia

Juvenile laryngeal papillomatosis: a rare cause of upper airway obstruction with possible dysplasia

Squamous Cell Carcinoma Originating from Adult Laryngeal Papillomatosis: Case Report and Review of the Literature

Contact Info

Product

Resources

About