Malignant teratomas of the thyroid gland: clinico-radiologic and cytomorphologic features of a rare entity

Miller, Daniel; Thompson, Lester D.�R.; Bishop, Justin A.; Rooper, Lisa M.; Ali, Syed Z.

doi:10.1016/j.jasc.2020.04.008

Cited by 13 publications

(25 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A growing mass or neck swelling were the primary sign in 14 (51.8%) patients, while odynophagia was observed in 4 (14.8%) patients. Four (14.8%) patients presented with other symptoms (4,11,17,18). Of these, one (3.7%) presented with severe airway obstruction, one (3.7%) with dysphonia, one (3.7%) with vocal cord paralysis and one (3.7%) case with hoarseness of voice.…”

Section: Literature Reviewmentioning

confidence: 99%

“…A total of 15 studies (11 case reports and 4 case series) described outcomes for 27 patients who were diagnosed with PTT and underwent thyroidectomy and in some cases an additional neck dissection (1,2,4,8,9,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). One study was excluded from the present systematic review (6).…”

Section: Literature Reviewmentioning

confidence: 99%

“…More specifically, the percentage of patients who had a preoperative neck US and CT for assessing nodules of thyroid gland were 66.6 and 57.1%, respectively. PET scan performed preoperatively in 3 out of 21 patients (14.2%), whereas only 2 cases had a Sestamibi scan (9.5%) (2,8,13,16,18). Moreover, FNA biopsy of suspicious lesions of thyroid gland was used in approximately 90.4% (n=19 out of 21 patients) of included patients.…”

Section: Literature Reviewmentioning

confidence: 99%

“…The proportion of patients who needed reoperation after their first surgery due to recurrence, either in the thyroid bed or in regional lymph nodes was 22.7% (n=5 out of 22 cases) (1,2,4,14,16). Distant metastases occurred in 8 (29.6%) patients; 5 (62.5%) had bone metastases, 3 (37.5%) had lung metastases and 3 (37.5%) were diagnosed with metastases in paraaortic and clavicular lymph nodes (4,11,(18)(19)(20). The average time of recurrence or disease progression after the first surgery was 3.6±6.25 months, while the average time of follow-up was 66,7±77 months.…”

Section: Literature Reviewmentioning

confidence: 99%

“…The average time of recurrence or disease progression after the first surgery was 3.6±6.25 months, while the average time of follow-up was 66,7±77 months. Nine (39.1%) patients died due to progression of the disease (4,9,11,(18)(19)(20).…”

Section: Literature Reviewmentioning

confidence: 99%

See 4 more Smart Citations

Primary thyroid teratoma in adults: A case report and systematic review of the literature

et al. 2021

View full text Add to dashboard Cite

Extragonadal germ cell tumors are uncommon in adults and only 2-5% of teratomas develop in extragonadal sites. Primary thyroid teratomas represent <0.1% of all primary thyroid gland neoplasms. In the present report, a case of primary thyroid teratoma in a 65-year-old female is described. Furthermore, the current literature regarding patients who were diagnosed with primary thyroid teratoma and underwent surgical resection was systematically reviewed. A total of 15 studies of 27 patients (age range, 17-65 years). Growing mass or neck swelling were the primary symptoms in 14 patients (51.8%). Only one (5.5%) patient was preoperatively diagnosed with malignant thyroid teratoma. All patients underwent thyroidectomy, but 6 cases had more advanced surgery, including lymph node dissection. A total of 12 patients received a combination of adjuvant chemoradiation postoperatively, 10 (45.4%) patients reported recurrence of disease and 8 (29.6%) were postoperatively diagnosed with distant metastases. A total of 9 (39.1%) patients died due to progression of the disease. In conclusion, primary thyroid teratomas are rare and difficult to diagnose preoperatively. In particular, malignant cases are very aggressive tumors with a considerably poor prognosis, even after surgical resection combined with adjuvant chemoradiation.

show abstract

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

See 3 more Smart Citations

Primary thyroid teratoma in adults: A case report and systematic review of the literature

et al. 2021

View full text Add to dashboard Cite

show abstract

Cytologic and histological features of rare nonepithelial and nonlymphoid tumors of the thyroid

Rossi

Pantanowitz

Hornick

2021

Cancer Cytopathology

View full text Add to dashboard Cite

Thyroid tumors can be classified into epithelial, nonepithelial, and nonprimary lesions. Nonepithelial thyroid tumors are rare. They can be of primary origin within the thyroid gland, arise secondary to contiguous growth from adjacent tissues, or represent metastatic disease. The incidence of nonepithelial tumors of the thyroid is only 1% to 2%, most of which are lymphomas; the remainder includes mesenchymal and histiocytic tumors. This review examines the cytohistological features of various nonepithelial and nonlymphoid tumors of the thyroid, including vascular lesions, neural tumors (including granular cell tumor and paraganglioma), smooth muscle tumors, solitary fibrous tumor, histiocytic neoplasms (eg, Langerhans cell histiocytosis and Rosai‐Dorfman disease), and follicular dendritic cell sarcoma. Their differential diagnosis is discussed, including recommendations to prevent the pitfall of mistaking these rare tumors for more common epithelial thyroid neoplasms.

show abstract

Comprehensive evaluation of cytomorphologic, histologic, and molecular features of DICER1‐altered thyroid lesions on FNA: A multipractice experience

Lengyel,

Lubin,

Hsiao

et al. 2024

Cancer Cytopathology

View full text Add to dashboard Cite

BackgroundDICER1 mutations, though infrequent, are encountered on preoperative molecular testing of indeterminate adult and pediatric thyroid fine‐needle aspiration (FNA) specimens. Yet, published cytomorphologic features of DICER1‐altered thyroid lesions are limited. Cytomorphological features of DICER1‐altered thyroid lesions were examined in a multipractice FNA cohort with clinical, radiological, and histologic data.MethodsThe cohort comprised 18 DICER1‐altered thyroid FNAs, with 14 having slides available and eight having corresponding surgical resections. Smears, ThinPrep, and formalin‐fixed cell block slides were reviewed and correlated with histology, when available. Clinical and radiologic data were obtained from the medical record.ResultsMost DICER1‐altered FNAs were classified as atypia of undetermined significance (94.4%). DICER1 mutations occurred in codons 1709 (50%), 1810 (27.8%), and 1813 (22.2%). One patient had an additional DICER1 p.D1822N variant in both of their FNAs. Lesions were often hypoechoic (35.3%) and solid (47.1%) on ultrasound. Notable cytomorphologic features include mixed but prominent microfollicular or crowded component, variable colloid, and insignificant nuclear atypia. On resection (n = 10), histologic diagnoses ranged from benign follicular adenoma and low‐risk follicular thyroid carcinoma to high‐grade follicular–derived nonanaplastic thyroid carcinoma. Subcapsular infarct‐type change was the most common histologic change. There was no evidence of recurrence or metastasis in eight patients on limited follow‐up.ConclusionDICER1‐altered thyroid lesions occurred frequently in young females and FNAs show RAS‐like cytomorphology including crowded, mixed macro‐/microfollicular pattern, and bland nuclear features. On resection, DICER1‐altered thyroid lesions include benign (50%), low‐risk lesions (30%), or high‐risk malignancies (20%).

show abstract

Malignant teratomas of the thyroid gland: clinico-radiologic and cytomorphologic features of a rare entity

Cited by 13 publications

References 18 publications

Primary thyroid teratoma in adults: A case report and systematic review of the literature

Primary thyroid teratoma in adults: A case report and systematic review of the literature

Cytologic and histological features of rare nonepithelial and nonlymphoid tumors of the thyroid

Comprehensive evaluation of cytomorphologic, histologic, and molecular features of DICER1‐altered thyroid lesions on FNA: A multipractice experience

Contact Info

Product

Resources

About