Malignant teratoma of the thyroid with primitive neuroepithelial and mesenchymal sarcomatous components

Craver, Randall; Lipscomb, Jane T.; Suskind, Dana L.; Velez, María

doi:10.1053/adpa.2001.27918

Cited by 27 publications

(21 citation statements)

References 20 publications

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“…Complete surgical excision with wide 2-3 cm margins is undertaken whenever possible to improve long-term survival 10 . In the current case, the initial clinical presentation led to rapid resection.…”

Section: Discussionmentioning

confidence: 90%

Conservative Multimodal Management of a Primitive Neuroectodermal Tumor of the Thyroid

et al. 2013

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Primitive neuroectodermal tumors (PNET) represent 1% of sarcomas. Head and neck peripheral PNETs have an intermediate prognosis between abdominopelvic disease and extremities. We here report the case of a 40-year old male who presented with primitive neuroectodermal tumor of the thyroid and was treated by multimodal treatment, including surgery, chemotherapy and intermediate dose radiotherapy. The patient is alive and fit with a functional larynx at 27 months. Multimodal treatments yield five-year survival rates of about 60%. Major drug regimens use vincristine, doxorubicin, ifosfamide or cyclophosphamide, dactinomycin and/or etoposide. Complete surgical excision is undertaken whenever possible to improve long-term survival. However, the relative radiosensitivity of tumors of the Ewing family, suggest multimodal treatment including adjuvant conformal radiotherapy in case of positive margins or poor response to chemotherapy rather than resection with 2-3 cm margins, which would imply laryngeal sacrifice for thyroid tumors. The role of expert rare tumor networks is crucial for optimal decision-making and management of such rare tumors on a case by case basis.

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Section: Discussionmentioning

confidence: 90%

Conservative Multimodal Management of a Primitive Neuroectodermal Tumor of the Thyroid

et al. 2013

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“…Complete surgical excision is undertaken whenever possible to improve long term survival. 5 Radiotherapy is indicated in Ewing sarcomas whenever there are close or positive margins or poor response to chemotherapy (necrosis<90%). It is associated with improved local control and improves survival.…”

Section: Discussionmentioning

confidence: 99%

Primitive neuroectodermal tumor of thyroid: a rare presentation

Shetty

Savant

Lokhandwala

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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<p>Extraskeletal Ewing’s sarcoma (EES) commonly arises in the soft tissues of trunk or extremities. EES is rare in the head and neck region; most having been documented in nasal cavity, paranasal sinuses and neck. Head and neck PNETs have an intermediate prognosis. We report the case of a 12 year old boy who presented with primitive neuroectodermal tumor of the thyroid and was treated with multimodal treatment including surgery, chemotherapy and radiotherapy. The patient is alive and fit with a functional larynx. Major drug regimens use vincristine, doxorubicin, ifosfamide or cyclophosphamide, dactinomycin and/or etoposide. Complete surgical excision is undertaken whenever possible to improve long-term survival. However, the relative radiosensitivity of tumors of the Ewing family, suggest multimodal treatment including adjuvant radiotherapy in case of positive margins or poor response to chemotherapy rather than resection with 2-3 cm margins, which would imply laryngeal sacrifice for thyroid tumors.</p>

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“…By 1999, nineteen cases of malignant teratoma of the thyroid had been reported in the medical literature, emphasizing the aggressive clinical course of the disease (1). After then, 3 cases have been reported (2, 6, 7). There were a predominance of primitive neuroepithelial component within mature squamous or glandular epithelial components and mature cartilage in our case.…”

Section: Discussionmentioning

confidence: 99%

Primary Malignant Teratoma with a Primitive Neuroectodermal Tumor Component in Thyroid Gland: A Case Report

et al. 2007

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Teratomas comprise the most common extragonadal germ cell tumors in childhood. Most teratomas involving the thyroid are benign and occur in children. However, the adult cases reported are mostly malignant and commonly arise in the thyroid. We report a case of a 31-yr-old female with a huge neck mass. Pathologic examination revealed it to be malignant teratoma composed of primitive neuroepithelial tissue with primitive neural tubes and loose myxoid to fibrous immature mesenchymal stroma. The patient underwent extensive evaluation of the thyroid gland with computed tomography (CT) scan and positron emission tomography (PET) scan, which revealed no evidence of metastatic disease. She underwent total thyroidectomy with bilateral modified radical neck dissection, intensive chemotherapy and radiotherapy. At 22-months of follow-up, the patient has remained euthyroid and showed no evidence of recurrence. This is the first case, to our knowledge, of malignant thyroid teratoma with a exuberant primitive neuroectodermal tumor component in Korea.

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Malignant teratoma of the thyroid with primitive neuroepithelial and mesenchymal sarcomatous components

Cited by 27 publications

References 20 publications

Conservative Multimodal Management of a Primitive Neuroectodermal Tumor of the Thyroid

Conservative Multimodal Management of a Primitive Neuroectodermal Tumor of the Thyroid

Primitive neuroectodermal tumor of thyroid: a rare presentation

Primary Malignant Teratoma with a Primitive Neuroectodermal Tumor Component in Thyroid Gland: A Case Report

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