Malignant teratoma of the thyroid in a pregnant woman

Pérez-Míes, Belén; Zapata, Rita María Regojo; García-Fernández, Eugenia; Serrano, Manuel Nistal Martín

doi:10.1016/j.anndiagpath.2009.07.004

Cited by 9 publications

(8 citation statements)

References 18 publications

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“…Establishing the diagnosis of malignant teratoma of the thyroid can be difficult on fine-needle aspiration. The cytologic specimens usually show spindle to oval cells with even chromatin and faint to absent cytoplasm intermixed with groups of cohesive epithelial cells [3]. The differential diagnosis of malignant teratoma of thyroid includes primary or secondary malignant thyroid neoplasms with spindle cell differentiation such as medullary carcinoma, SETTLE, primary or metastatic thyroid sarcoma, and anaplastic carcinoma.…”

Section: Commentmentioning

confidence: 98%

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Images in Endocrine Pathology: Case 1

2011

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Section: Commentmentioning

confidence: 98%

“…However in adults, the microscopically malignant teratomas follow an aggressive course, i.e., regional and distant metastases [1][2][3]. Fig.…”

Section: Commentmentioning

confidence: 99%

Images in Endocrine Pathology: Case 1

2011

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“…A total of 15 studies (11 case reports and 4 case series) described outcomes for 27 patients who were diagnosed with PTT and underwent thyroidectomy and in some cases an additional neck dissection (1,2,4,8,9,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). One study was excluded from the present systematic review (6).…”

Section: Literature Reviewmentioning

confidence: 99%

“…More specifically, the location of recurrence in these 11 patients was the thyroid bed (n=4), the central compartment lymph nodes (n=3), the lateral lymph nodes (n=2) and the mediastinum (n=2). The proportion of patients who needed reoperation after their first surgery due to recurrence, either in the thyroid bed or in regional lymph nodes was 22.7% (n=5 out of 22 cases) (1,2,4,14,16). Distant metastases occurred in 8 (29.6%) patients; 5 (62.5%) had bone metastases, 3 (37.5%) had lung metastases and 3 (37.5%) were diagnosed with metastases in paraaortic and clavicular lymph nodes (4,11,(18)(19)(20).…”

Section: Literature Reviewmentioning

confidence: 99%

Primary thyroid teratoma in adults: A case report and systematic review of the literature

et al. 2021

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Extragonadal germ cell tumors are uncommon in adults and only 2-5% of teratomas develop in extragonadal sites. Primary thyroid teratomas represent <0.1% of all primary thyroid gland neoplasms. In the present report, a case of primary thyroid teratoma in a 65-year-old female is described. Furthermore, the current literature regarding patients who were diagnosed with primary thyroid teratoma and underwent surgical resection was systematically reviewed. A total of 15 studies of 27 patients (age range, 17-65 years). Growing mass or neck swelling were the primary symptoms in 14 patients (51.8%). Only one (5.5%) patient was preoperatively diagnosed with malignant thyroid teratoma. All patients underwent thyroidectomy, but 6 cases had more advanced surgery, including lymph node dissection. A total of 12 patients received a combination of adjuvant chemoradiation postoperatively, 10 (45.4%) patients reported recurrence of disease and 8 (29.6%) were postoperatively diagnosed with distant metastases. A total of 9 (39.1%) patients died due to progression of the disease. In conclusion, primary thyroid teratomas are rare and difficult to diagnose preoperatively. In particular, malignant cases are very aggressive tumors with a considerably poor prognosis, even after surgical resection combined with adjuvant chemoradiation.

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“…2 In previous case reports of primary malignant teratoma with FNA findings, patients have ranged in age from 13 to 64 years old, and as with most other thyroid malignancies, the majority were female. 1,5,[7][8][9][10][11][12][13][14] Given the germ cell origin of thyroid teratomas, and the overall rarity of these tumors, it is interesting that four cases have been previously reported during pregnancy 15 ; all were malignant.…”

Section: Introductionmentioning

confidence: 99%

Malignant teratoma of the thyroid: A difficult diagnosis by fine‐needle aspiration

Starling¹,

Sabra²,

Brady³

et al. 2019

Diagnostic Cytopathology

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Primary thyroid teratomas are rare, usually benign, and typically occur in children. We report the unusual occurrence of a malignant thyroid teratoma in a young man. Initial ultrasound and CT studies revealed an 8.5 heterogeneous mass involving the entire right thyroid lobe causing tracheal compression and deviation. Fine‐needle aspiration (FNA) revealed malignant cells with possible neuroendocrine features. Similar findings have been previously reported, with an occasional interpretation as possible medullary thyroid carcinoma. In no report, as with our case, has the correct diagnosis been suggested with FNA. The surgical specimen contained abundant primitive neuroepithelium with a very minor component of mature ectodermal tissue in one area. Like this case, an abundance of immature neuroepithelium has been reported in essentially all previous reports of primary malignant thyroid teratoma, sometimes creating a challenge to find another type of germ cell tissue. Array comparative genomic hybridization studies in this case revealed a markedly complex karyotype including gain of chromosome 12 and loss of 17p. Amplification of MYCN, EWSR1 rearrangement and isochromosome 12p were not identified, providing no evidence for neuroblastoma or Ewing sarcoma/peripheral neuroectodermal tumor, both of which have also rarely been reported as primary thyroid tumors. With the use of cisplatinum‐based chemotherapy combined with radiation, survival times have increased dramatically. Our patient is now disease free and back to his normal activities after relatively short follow‐up. Although rare, it is important to be aware that teratomas may present as a thyroid nodule. Recognition by FNA is challenging, and requires multiple modalities for full identification.

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Malignant teratoma of the thyroid in a pregnant woman

Cited by 9 publications

References 18 publications

Images in Endocrine Pathology: Case 1

Images in Endocrine Pathology: Case 1

Primary thyroid teratoma in adults: A case report and systematic review of the literature

Malignant teratoma of the thyroid: A difficult diagnosis by fine‐needle aspiration

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