Malignant Secondary Parotid Tumors

Rees, Riley S.; Maples, Michael D.; Lynch, John B.; Rosenfeld, L

doi:10.1097/00007611-198109000-00007

Cited by 20 publications

(8 citation statements)

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“…A few cases have been reported in the literature (10)(11)(12)(13)(14). If a malignant lymphoepithelial lesion is identified on FNAB of the parotid gland, it is a prerequisite to determine whether it is a primary or a metastatic one.…”

Section: Discussionmentioning

confidence: 99%

Parotis Bezi Kitlesi Olarak Semptom Veren Nazofarenks Karsinomu

Verim¹,

Çalım²,

Yüksel³

et al. 2014

Haseki

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ÖzetParotisin metastatik tümörleri nadir olarak görülmesine rağmen diğer tükürük bezlerinin metastatik kitlelerinden daha sık olarak izlenir. Bu bezin metastazdan diğer tükürük bezlerine göre daha sık etkilenmesinin nedeni içerisinde bulunan intraglandular lenf nodları ve periglandüler nod sayısının daha fazla olmasındandır. Kliniğimize yüzünün her iki yanında parotis kitlesi nedeni ile refere edilen ve ince iğne aspirasyon biopsilerinin sonucu maligniteyi düşündüren bulgular olarak rapor edilen bir hasta vesilesiyle total parotidektomi kararı vermeden önce nazofarinks karsinom metastazını ekarte etmenin ve dikkatli bir endoskopik muayene ve manyetik rezonans görüntülemenin önemini vurgulamak istedik. Abs tractEven though metastatic tumors of the parotid gland are rarely seen, they are observed more frequently than other salivary gland metastatic masses. The reason why this gland is more frequently affected by metastatic tumors as compared to other salivary glands relies on the higher number of intraglandular and periglandular lymph nodes that the parotid gland contains. The incidence of metastatic parotid masses is relatively low compared to other head and neck neoplasms, consequently, few cases have been reported in the literature. Here, we present a patient referred to our clinic with parotid gland masses on both sides suggesting malignant neoplasm after fine needle aspiration biopsy of both sides. In this report, we aimed to draw attention to nasopharyngeal carcinoma metastasis in the differential diagnosis of parotid gland masses and to emphasize the importance of a careful endoscopic examination and magnetic resonance imaging before deciding on total parotidectomy. (The Me di cal Bul le tin of Ha se ki 2014; 52: 130-2)

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Section: Discussionmentioning

confidence: 99%

Parotis Bezi Kitlesi Olarak Semptom Veren Nazofarenks Karsinomu

Verim¹,

Çalım²,

Yüksel³

et al. 2014

Haseki

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“…These two account for about 80% of major salivary gland metastases. In contrast, metastases from more distant sites account for only 2-4% of major salivary gland malignancies [20,21] and, similar to other head and neck sites, usually are from breast, lung and kidney primaries. In a study of 108 metastases identified from 11,000 salivary gland pathology specimens (9.8%), Seifert et al found that 6 (5.6%) were metastatic RCC [22].…”

Section: Discussionmentioning

confidence: 99%

p63 Immunohistochemistry Differentiates Salivary Gland Oncocytoma and Oncocytic Carcinoma from Metastatic Renal Cell Carcinoma

McHugh

Hoschar

Dvorakova

et al. 2007

Head and Neck Pathol

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Metastatic renal cell carcinoma (RCC) can pose diagnostic challenges in the head and neck often resembling benign and malignant oncocytic lesions. Immunohistochemical panels have been reported to help with this differential but are not entirely specific or sensitive. We have noticed that p63 routinely stains salivary gland oncocytomas but not metastatic RCC. Nineteen oncocytomas, 9 cases of oncocytosis, 9 oncocytic carcinomas and 16 head and neck metastatic RCC were studied. Morphologic features evaluated were cytoplasmic character (clear versus oncocytic), Fuhrman nuclear grade, mitotic rate, growth pattern, presence of lumens/blood lakes and stromal characteristics. Tumors were stained with antibodies to p63, renal cell carcinoma marker (RCCm), CD10, and vimentin. Eight benign oncocytic tumors (29%) had clear cell features while 6 metastatic RCC (37%) had oncocytic features. Median Fuhrman nuclear grade was 2 in oncocytoma and oncocytosis and 3 both oncocytic carcinoma and metastatic RCC. Mitotic rates were only significantly different between benign oncocytic tumors and metastatic RCC. All oncocytomas had lumina compared to half of metastatic RCC, all of which also demonstrated blood lakes. Seven benign oncocytic tumors (25%) and 5 oncocytic carcinomas (56%) had RCC-like vascular stroma. All primary salivary gland tumors were positive for p63, predominately in basal cell-type distribution. None of the metastatic RCC was positive. RCCm was entirely specific but lacked sensitivity for metastatic RCC while CD10 and vimentin showed variable sensitivity and specificity. While clinical history and morphology usually are adequate, demonstration of p63 staining can definitively exclude metastatic RCC from the differential diagnosis of similar appearing tumors in salivary glands, namely oncocytoma and oncocytic carcinoma, with 100% specificity and sensitivity. While RCCm, CD10, and vimentin performed adequately, they were significantly less reliable than p63 with both false positives and false negatives.

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“…Metastases to salivary glands most often (in about 80%) originate from squamous cell carcinomas of the head and neck region [4], followed by cutaneous as well as mucosal melanomas [1]. Carcinomas of the breast, lung, kidney and prostate are those prima-ries that may also potentially metastasize to salivary glands [4,5,6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Renal clear cell carcinoma metastasis to salivary glands – a series of 9 cases: clinico-pathological study

Majewska¹,

Skálová²,

Radecka³

et al. 2016

pjp

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Metastatic tumors involving salivary glands arising from the non-head and neck area are very rare. Renal cell carcinoma (RCC) is known for its high propensity for metastasis to unusual localizations. RCC metastasis to the maxillofacial area is an uncommon event (16%), but metastasis to salivary glands is extremely rare. We report a series of 9 such cases retrieved from two institutions. The group included 6 females and 3 males. The age at diagnosis ranged from 60 to 97 years (mean 72.6 years). The tumors involved the parotid gland in 7 cases, and the submandibular and small salivary gland of the oral cavity in 1 case each. The size of tumors ranged from 0.4 to 5 cm. Total parotidectomy with selective neck dissection was performed in 4 cases, while superficial parotidectomy was performed in 1 case and simple resection in 3 cases. Histologically, all the tumors were clear cell renal cell carcinomas, and therefore the differential diagnosis mainly included clear cell variants of salivary gland carcinomas. The parotid gland was the initial manifestation of renal malignancy in 4 of the cases, while in the remaining 5 cases a history of RCC had been known. The salivary gland involvement developed from 11 months to 13 years after the time of diagnosis of the primary tumor. In 2 cases it was the first site of dissemination. Pathologists need to maintain a high index of suspicion for the possibility of metastasis when confronted with oncocytic or clear cell neoplasms developing in salivary glands. RCC, although rare, should be included in this differential diagnosis.

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Malignant Secondary Parotid Tumors

Cited by 20 publications

References 0 publications

Parotis Bezi Kitlesi Olarak Semptom Veren Nazofarenks Karsinomu

Parotis Bezi Kitlesi Olarak Semptom Veren Nazofarenks Karsinomu

p63 Immunohistochemistry Differentiates Salivary Gland Oncocytoma and Oncocytic Carcinoma from Metastatic Renal Cell Carcinoma

Renal clear cell carcinoma metastasis to salivary glands – a series of 9 cases: clinico-pathological study

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