Malignant schwannoma of the sympathetic chain, combined with plexiform neurofibromas of the tongue and larynx in a patient with von Recklinghausen's disease

Handžić-Ćuk, J.; Simovic, Sladjana; Bumber, Željko

doi:10.1007/bf02630753

Cited by 7 publications

(5 citation statements)

References 4 publications

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“…The features of laryngeal MPNST have been discussed on the previous reports [ 9–12 ]. This type of tumor was identified submucosally in a previous study [ 11 ] and in our patient. Ipsilateral vocal fold palsy was present in one case [ 11 ].…”

Section: Discussionsupporting

confidence: 79%

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Laryngeal malignant peripheral nerve sheath tumor mixed with high- and low-grade malignancies

Kajiyama

Komori

Iguchi

et al. 2021

Journal of Surgical Case Reports

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Malignant peripheral nerve sheath tumors (MPNSTs), as defined by immunohistochemical evaluation, are identified along a spectrum ranging from atypical neurofibroma to high-grade MPNST because these tumors are similar in terms of cell shape and tissue components on hematoxylin–eosin (HE) staining. The patient was a 57-year-old male referred to our hospital, with a recurrent red tumor at the anterior commissure of the larynx and submucosal swelling of the right vocal fold. A surgical specimen from a right horizontal partial laryngectomy was evaluated immunohistochemically. A high-grade MPNST lesion was included in the submucosal white tumor, whereas a low-grade MPNST lesion was encountered around the high-grade MPNST lesion. This tumor may involve different malignancies even when it is small. Although intra-tumor heterogeneity in cancers has been reported recently, careful immunohistochemical examination can be important and beneficial for eradicating the tumor while preserving vocal function.

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Section: Discussionsupporting

confidence: 79%

“…This type of tumor was identified submucosally in a previous study [ 11 ] and in our patient. Ipsilateral vocal fold palsy was present in one case [ 11 ]. No patients with pain have been reported.…”

Section: Discussionsupporting

confidence: 79%

Laryngeal malignant peripheral nerve sheath tumor mixed with high- and low-grade malignancies

Kajiyama

Komori

Iguchi

et al. 2021

Journal of Surgical Case Reports

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“…One of their eight cases (twelve percent) presented with a horner's syndrome and that malignant schwannomas were rare and often associated with familial disorders such as neurofibromatosis [11]. The differential diagnoses of these lesions are broad.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Paediatric Neck Swelling: Cervical Sympathetic Chain Schwannoma

Keane

Francis

Thambipillai

2013

Case Reports in Otolaryngology

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“…Neurofibromatosis due to von Recklinghausen's disease (central type II and peripheral type I) may present clinically as multiple neurofibromas, but solitary neurofibromas can also be the first manifestation of general peripheral neurofibromatosis [2]. Malignancy rarely occurs in solitary neurofibromas but has been observed in 3-30% of cases with von Recklinghausen's neurofibromatosis [4,7,9,11,12,14]. Such malignancy is thought to be stimulated by hormone imbalances associated with puberty [7].…”

Section: Introductionmentioning

confidence: 99%

“…Neurofibromas of the facial nerve have been described and mostly have been located intratemporally [9,10,13]. Neurofibromas of the vagus nerve, glossopharyngeal nerve, hypoglossal nerve, cervical sympathetic chain and trigeminal nerve have occurred occasionally [1,4,7,12]. When they are situated along the branching of the trigeminal nerve, the nose, paranasal sinuses, infratemporal fossa, parapharyngeal space and mandibular region can be affected [1,12].…”

Section: Introductionmentioning

confidence: 99%

Neurofibroma of the auriculotemporal nerve

Cartellieri

Swoboda

2000

European Archives of Oto-Rhino-Laryngology

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Despite the extensive branching of the trigeminal nerve, solitary neurofibromas along its branches are a rare finding. We report our management of a neurofibroma of the right auriculotemporal nerve in a 46-year-old women. A chain of small nodules palpable in the right postauricular region was associated with increasing pain radiating into the postauricular and temporoparietal regions of her head. Magnetic resonance imaging and computed tomography showed several small ovoid lesions extending from the postauricular region to the infratemporal fossa. The lesions were removed surgically. The facial nerve adhered to the dorsal side of the largest nodule, but this could be removed without sequelae. The auriculotemporal nerve was identified as the nerve of origin and was removed together with the lesions. Histopathological examination was consistent with a neurofibroma with early plexiform cell formations. Clinical findings are discussed.

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Malignant schwannoma of the sympathetic chain, combined with plexiform neurofibromas of the tongue and larynx in a patient with von Recklinghausen's disease

Cited by 7 publications

References 4 publications

Laryngeal malignant peripheral nerve sheath tumor mixed with high- and low-grade malignancies

Laryngeal malignant peripheral nerve sheath tumor mixed with high- and low-grade malignancies

A Rare Case of Paediatric Neck Swelling: Cervical Sympathetic Chain Schwannoma

Neurofibroma of the auriculotemporal nerve

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