1996
DOI: 10.1293/tox.9.107
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Malignant schwannoma of the intracranial trigeminal nerve in a 19-week-old female sprague-dawley rat.

Abstract: Light microscopic, histochemical and ultrastructural observations were conducted to examine a

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Cited by 8 publications
(5 citation statements)
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“…The incidence of spontaneous intracranial tumors is very low in rats, with the exception of pituitary neoplasms 1 , 2 . Spontaneous tumors of the pituitary gland are one of the most common neoplasms in aging Sprague-Dawley (SD) rats, with most pituitary tumors arising from the pars distalis.…”
mentioning
confidence: 97%
“…The incidence of spontaneous intracranial tumors is very low in rats, with the exception of pituitary neoplasms 1 , 2 . Spontaneous tumors of the pituitary gland are one of the most common neoplasms in aging Sprague-Dawley (SD) rats, with most pituitary tumors arising from the pars distalis.…”
mentioning
confidence: 97%
“…Sequential sections of nodules were stained with periodic acid Schiff (PAS). Immunohistochemistry was performed with antibodies to proliferating cell nuclear antigen (PCNA) to detect the proliferative activity 14 , pancytokeratin (CK) as an epithelial cell marker, vimentin as a mesenchymal cell marker 15 , the common acute lymphoblastic leukemia antigen 10 (CD10) as a uterine interstitial cell marker 16 , α-smooth muscle actin (SMA) and desmin as muscular cell markers 15 , S-100 as a Schwann cell and adipocyte marker 17 , and estrogen receptor α (ER) and progesterone receptor (PgR) to detect steroid hormone receptors 18 . Detailed staining protocols for all antibodies are listed in Table 1…”
mentioning
confidence: 99%
“…There were no incidences of schwannoma in similarly aged historical control rats at the test facility. However, based on reports of schwannoma in younger rats 27,28 and the single occurrence in the 6-month study, this finding was considered incidental.…”
Section: Introductionmentioning
confidence: 99%