Malignant schwannoma of cranial nerves

Robertson, Ian; Cook, Martin; Wilson, David; Henderson, D.W.

doi:10.3109/00313028309085169

Cited by 27 publications

(8 citation statements)

References 11 publications

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“…MPNST of the mandible are extremely rare and clinically of marginal importance. Only a few cases are known to date [19][20][21], some of them with localized or fusiform canal widening, or with a widened foramen mentale [20,22,23]. Perineural spreading to the intracranial portion of the trigeminal nerve is characteristic, as well as spreading to other trigeminal nerve branches and the skull base [5].…”

Section: Discussionmentioning

confidence: 99%

Unilateral widening of the inferior alveolar nerve canal: a rare anatomic variant mimicking disease

et al. 2012

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We report a case of an asymptomatic healthy 49-year-old male patient with an incidental finding of enlargement of the right inferior alveolar nerve (IAN) canal (9 vs. 4 mm). After 2 years, follow-up magnetic resonance imaging (MRI) revealed no change in the findings. In addition, MR-based diffusion tensor imaging with tractography of the right and left mandibular nerves showed that the difference in size between the right and left nerves was caused by an increased number of nerve fibers in the right IAN. During the entire follow-up period of 4 years, the patient remained symptom-free. Therefore, we suggest that the enlargement in our patient was a pure anatomic variant. However, a multitude of conditions are known to produce the identical radiological appearance in conventional radiology, including benign and malignant tumors, vascular malformations, and inflammatory disorders. We describe these pathologies in more detail as well as the possibilities for examinations with different MRI sequences.

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Section: Discussionmentioning

confidence: 99%

Unilateral widening of the inferior alveolar nerve canal: a rare anatomic variant mimicking disease

et al. 2012

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“…5,6,12) Intracranial MPNST is extremely rare, with only 24 cases reported to date. [1][2][3][4]8,9,11,[13][14][15][16][17][18][19][20][21][22][23]26,27,29) The tumor originated in the trigeminal nerve or the acoustic nerve in most of these cases. Accordingly, the lesion is generally located mainly in the middle cranial fossa and the cerebellopontine angle.…”

Section: Introductionmentioning

confidence: 99%

Malignant Peripheral Nerve Sheath Tumor in the Anterior Skullb Base Associated With Neurofibromatosis Type 1-Case Report-

Ueda

Saito

Horiguchi

et al. 2004

Neurol. Med. Chir.(Tokyo)

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A 36-year-old man presented with a tumor in the anterior skull base manifesting as headache and visual disturbance. Neurofibromatosis type 1 (NF-1) was identified in early childhood in the patient, and also in his father. Subtotal excision of the tumor was performed, leaving the portion extending outside of the cranium. The histological diagnosis was malignant peripheral nerve sheath tumor. Local radiotherapy was instituted postoperatively. Facial paralysis and dysphagia appeared 7 months after the first operation. Magnetic resonance imaging revealed new lesions in the lateral ventricle and around the brainstem. These tumors were also subtotally excised, but the patient died 10 months after the first operation. The tumor very likely originated from the meningeal branch of the trigeminal nerve. Treatment of such tumors developing inside the cranium should include the widest resection possible, followed by irradiation of the entire neuraxis including the spinal cord to inhibit dissemination through the cerebrospinal fluid. Treatment should be started as quickly as possible if the tumor is associated with NF-1, because of the poor prognosis associated with this condition.

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“…These 29 articles provided 35 cases, to which we added 1 additional case from our institu tion. 1,2,[4][5][6][7][8]10,11,[14][15][16][17][18][19][20][21]24,[26][27][28][29][30][32][33][34][35][36][37] The complete results of our analysis of 36 cases are detailed in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Malignant peripheral nerve sheath tumors of the trigeminal nerve: a systematic review of 36 cases

Schmidt¹,

Yick²,

Boghani³

et al. 2013

FOC

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Object Malignant peripheral nerve sheath tumors (MPNSTs) are a rare form of malignancy arising from the Schwann cells of peripheral nerves. MPNSTs of the trigeminal nerve are exceptionally rare, with only a handful of reports in the literature. These tumors are typically very aggressive, resulting in significant patient morbidity and a generally grim prognosis. Most current reports suggest that radical resection with radiation therapy offers the best benefit. In this study, the authors systematically reviewed the world English-language literature on MPNSTs of the trigeminal nerve to analyze the presentations, treatment options, and outcomes for patients with this disease. Methods A literature search for MPNSTs of the trigeminal nerve confined to nonanimal, English-language articles was conducted utilizing the PubMed database, with additional cases chosen from the references of selected articles. Only cases of confirmed MPNSTs of the trigeminal nerve or its peripheral branches, based upon surgical, pathological, or radiological analysis, were included. Results From the literature search, 29 articles discussing 35 cases of MPNSTs of the trigeminal nerve were chosen. With the addition of 1 case from their own institution, the authors analyzed 36 cases of trigeminal MPNSTs. The average age of onset was 44.6 years. These tumors were more commonly seen in male patients (77.1%). The gasserian ganglion was involved in 36.1% of the cases. Of the cases in which the nerve distribution was specified (n = 25), the mandibular branch was most commonly involved (72.0%), followed by the maxillary branch (60.0%) and the ophthalmic branch (32.0%), with 44.0% of patients exhibiting involvement of 2 or more branches. Altered facial sensation and facial pain were the 2 most commonly reported symptoms, found in 63.9% and 52.8% of patients, respectively. Mastication difficulty and diplopia were seen in 22.2% of patients, facial weakness was seen in 19.4%, and hearing loss was present in 16.7%. With regard to the primary treatment strategy, 80.6% underwent resection, 16.7% underwent radiation therapy, and 2.9% received chemotherapy alone. Patients treated with complete resection followed by postoperative radiation therapy had the most favorable outcomes, with no patients showing evidence of disease recurrence with a mean follow-up of 34.6 months. Patients treated with incomplete resection followed by postoperative radiation therapy had more favorable outcomes than patients treated with incomplete resection without radiation therapy or radiation therapy alone. Conclusions Trigeminal MPNSTs most commonly present as altered facial sensation or facial pain, although they exhibit a number of other clinical manifestations, including the involvement of other cranial nerves. While a variety of treatment options exist, due to their highly infiltrative nature, aggressive resection followed by radiation therapy appears to offer the greatest chance of recurrence-free survival.

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Malignant schwannoma of cranial nerves

Cited by 27 publications

References 11 publications

Unilateral widening of the inferior alveolar nerve canal: a rare anatomic variant mimicking disease

Unilateral widening of the inferior alveolar nerve canal: a rare anatomic variant mimicking disease

Malignant Peripheral Nerve Sheath Tumor in the Anterior Skullb Base Associated With Neurofibromatosis Type 1-Case Report-

Malignant peripheral nerve sheath tumors of the trigeminal nerve: a systematic review of 36 cases

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