Malignant rhabdoid-tumor cell line showing neural and smooth-muscle-cell phenotypes

Sugimoto, Tohru; Hosoi, Hajime; Horii, Yusuke; Ishida, Hiroyuki; Mine, Hiroshi; Takahashi, Katsuhito; Abe, Tatsuo; Ohta, Shigeru; Sawada, Tadashi

doi:10.1002/(sici)1097-0215(19990827)82:5<678::aid-ijc10>3.0.co;2-k

Cited by 33 publications

(38 citation statements)

References 23 publications

(27 reference statements)

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“…Although several immunohistochemical studies with single-labeling methods have reported coexpression of cytokeratin and vimentin, no clear localization of these intermediate filaments in cytoplasm has been clarified (9,10,13,17,18). With regard to cytokeratin subunits, Shiratsuchi et al (18) reported that all six cases of MRT diffusely expressed CKs 8 and 18.…”

Section: Discussionsupporting

confidence: 65%

“…Also, expression of CKs 8 and 18 is observed in some malignant mesenchymal tumors such as leiomyosarcoma and malignant peripheral nerve sheath tumor (20), in addition to epithelioid sarcoma and synovial sarcoma (20,21), which are classified as miscellaneous tumors. Therefore, the (6,17), epithelial (10,22), myogenic (10,23), and smooth-muscle-cell (16) phenotype. Whatever its pathogenesis may be, the relatively uniform clinicopathological profile of MRT supports its acceptance as a specific disease entity of malignancy.…”

Section: Discussionmentioning

confidence: 99%

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Subcellular Distribution of Cytokeratin and Vimentin in Malignant Rhabdoid Tumor: Three-Dimensional Imaging with Confocal Laser Scanning Microscopy and Double Immunofluorescence

et al. 2001

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Subcellular Distribution of Cytokeratin and Vimentin in Malignant Rhabdoid Tumor: Three-Dimensional Imaging with Confocal Laser Scanning Microscopy and Double Immunofluorescence

et al. 2001

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“…About 13 MRT cell lines have been documented (12,13). The expression of EGFR on MRT cell lines was shown by immunohistochemistry and cell growth inhibition by anti-EGFR antibody (14).…”

Section: Introductionmentioning

confidence: 97%

“…However, the expression of EGFR on MRT tissues and the phosphorylation of EGFR by epidermal growth factor (EGF) on MRT cell lines have never been examined. We established two MRT cell lines from two MRT patients (13,15). In this study, we confirm the genetic diagnoses of these cell lines to MRT by the alteration of INI1 gene (16).…”

Section: Introductionmentioning

confidence: 99%

Antitumor Activity of Gefitinib in Malignant Rhabdoid Tumor Cells In vitro and In vivo

Kuwahara¹,

Hosoi²,

Osone³

et al. 2004

Clinical Cancer Research

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“…Various cellular origins of MRT, such as neuroectodermal (8,9,12), neural (13)(14)(15), epithelial (16), histiocytic (17) or myogenic (18), have been proposed. Despite the variability observed in tumor location and histology, most rhabdoid tumors share a similar genetic origin and are characterized by the presence of mutations in the hSNF5/INI1 gene on chromosome band 22q11.2 (19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Expression of neural stem cell markers in malignant rhabdoid tumor cell lines

Okuno

Ohta²,

Katô³

et al. 2009

Oncol Rep

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Abstract. Malignant rhabdoid tumor (MRT) is considered to display multi-phenotypic characteristics but the true origin of this tumor remains unknown. In recent years, the concept of the cancer stem cell (CSC) has drawn great attention. In the present study we investigated six MRT cell lines (TM87-16, STM91-01, TTC642, TTC549, YAM-RTK-1 and TTC1240), for CD133, nestin and Musashi-1 (Msi-1), which are considered to be CSC as well as neural stem cell (NSC) markers, using assays for cell viability and apoptosis, reverse transcriptional polymerase chain reaction (RT-PCR), semiquantitative PCR and Western blot analysis before and after differentiation-induction with N-(4-hydroxyphenyl) retinamid (4-HPR). Before differentiation-induction with 4-HPR, CD133 was detected in three MRT cell lines, nestin in three cell lines and Msi-1 in five cell lines. In TTC549 after differentiation-induction with 4-HPR, nestin and Msi-1 were down-regulated in a time-dependent manner. Similar downregulation of Msi-1 was recognized in YAM-RTK-1. In STM91-01, CD133 was gradually down-regulated and Msi-1 was down-regulated after a transient increase. Results from our study indicated that 4-HPR might be effective in some MRTs. Expression of NSC markers showed that some MRTs contain a subpopulation of NSC and down-regulation of NSC markers in MRT cells provides supportive evidence that many MRTs could be considered of neuroectodermal origin.

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Malignant rhabdoid-tumor cell line showing neural and smooth-muscle-cell phenotypes

Cited by 33 publications

References 23 publications

Subcellular Distribution of Cytokeratin and Vimentin in Malignant Rhabdoid Tumor: Three-Dimensional Imaging with Confocal Laser Scanning Microscopy and Double Immunofluorescence

Subcellular Distribution of Cytokeratin and Vimentin in Malignant Rhabdoid Tumor: Three-Dimensional Imaging with Confocal Laser Scanning Microscopy and Double Immunofluorescence

Antitumor Activity of Gefitinib in Malignant Rhabdoid Tumor Cells In vitro and In vivo

Expression of neural stem cell markers in malignant rhabdoid tumor cell lines

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