Malignant Proliferating Trichilemmal Tumors—Report of Three Cases

Mehregan, Amir H.; Lee, K.C.

doi:10.1111/j.1524-4725.1987.tb03579.x

Cited by 70 publications

(54 citation statements)

References 6 publications

(5 reference statements)

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“…Malignant transformation from proliferating trichilemmal tumours can also occur in rare instances. Mehregan and Lee 11 indicated that rapid growth or exophytic enlargement of the long‐standing nodule and histologically extensive areas of severe dysplasia and surrounding dermal invasion are signs of malignant transformation. Although our patient could not tell us the exact duration of each tumour, she did admit that tumours showing typical trichilemmal cyst histopathology were of short duration, changed in morphology and did not disappear.…”

Section: Discussionmentioning

confidence: 99%

Keratitis, ichthyosis and deafness syndrome with development of multiple hair follicle tumours

Kim

et al. 2002

Br J Dermatol

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We report multiple occurrences of various kinds of tumours that originate from hair follicles in a patient diagnosed with KID (keratitis, ichthyosis, deafness) syndrome. These tumours are diagnosed as: (i) trichilemmal cysts in early lesions; (ii) proliferating trichilemmal tumours in moderate duration lesions; and (iii) malignant proliferating trichilemmal tumours in advanced lesions that are thought to progress from benign trichilemmal lesions. This three-step process raises the hypothesis of a multihit model that could account for the frequent development of tumours in KID patients.

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Section: Discussionmentioning

confidence: 99%

Keratitis, ichthyosis and deafness syndrome with development of multiple hair follicle tumours

Kim

et al. 2002

Br J Dermatol

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“…15,23 Malignant pilar tumors range from in situ foci within an otherwise classical pilar tumor to frankly invasive neoplasms with a destructive growth pattern. 24 Therefore, it was not considered in the differential diagnosis of the present case, which was histologically a typical example of a trichilemmal (pilar) cyst.…”

Section: Discussionmentioning

confidence: 93%

Trichilemmal Cyst With Carcinoma In Situ Within an Atypical Fibroxanthoma

Arsenovic

Sen²,

Naik³

et al. 2009

The American Journal of Dermatopathology

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A 91-year-old lady presented with an 8-month history of a slow growing keratotic nodule on the forehead, which was excised. Histological examination showed a well-defined lesion with marked cellular pleomorphism. Numerous mitoses were present. The cells stained positively with CD10 and CD68 and weakly with smooth muscle actin. However, the tumor was negative for cytokeratins (AE1/AE3), epithelial membrane antigen (EMA), S100, Melan A, HMB45, leukocyte common antigen (LCA), desmin, and CD31. Therefore, the lesion was designated as atypical fibroxanthoma (AFX) by exclusion. Within the AFX, there was also a cyst lined by squamous epithelium showing pilar keratinization. The epithelium showed full-thickness dysplasia with increased mitotic activity and was stained positively with AE1/AE3, thus supporting our view of carcinoma in situ within the wall of the cyst. To the best of our knowledge, this article describes the first case of trichilemmal cyst with carcinoma in situ arising within an AFX.

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“…In some cases of PTT, atypical areas were found to be admixed with well-differentiated lobules [18]. Moreover, cases with little or no cytological atypia displayed aggressive behavior and vice versa [19].…”

Section: Discussionmentioning

confidence: 99%

Recurrent Proliferating Trichilemmal Tumor of the Vulva

Moraloğlu

Güngör²,

Özyer³

et al. 2013

Journal of Lower Genital Tract Disease

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Proliferating trichilemmal tumor (PTT) is a rare but morphologically distinct tumor that usually arises on the scalp of elderly women. It is composed of multiple cysts consisting of squamous epithelium with trichilemmal keratinization without granular layer interposition. Vulvar proliferating trichilemmal cyst is very rare, with, to the best of our knowledge, only 3 cases previously reported in the literature. We describe a 39-year-old woman with recurrent PTT on the left labium majus of the vulva, which had been excised from the same side 5 years before. She had a palpable nodule, approximately 2 cm in size, which was firm, mobile, and nontender; without erythema and ulceration; and covered by normal skin on the vulva. There was no inguinal lymphadenopathy. The lesion was removed by wide surgical excision; because of the tissue elasticity, primary closure was possible. The pathology result was reported as proliferating trichilemmal carcinoma with tumor-free margins. Although local recurrence after wide excision is rare, we recommend complete excision for treatment of PTT and long-term follow-up because of the possibility of recurrence.

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Malignant Proliferating Trichilemmal Tumors—Report of Three Cases

Cited by 70 publications

References 6 publications

Keratitis, ichthyosis and deafness syndrome with development of multiple hair follicle tumours

Keratitis, ichthyosis and deafness syndrome with development of multiple hair follicle tumours

Trichilemmal Cyst With Carcinoma In Situ Within an Atypical Fibroxanthoma

Recurrent Proliferating Trichilemmal Tumor of the Vulva

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