Malignant Proliferating Pilar Tumor With Sarcomatous Transformation (“Carcinosarcoma”): Case Report With Molecular Profile
Jakob M. T. Moran,
Mai P. Hoang,
Adrian Mariño-Enríquez
et al.
Abstract:Malignant proliferating pilar tumors (MPPTs) are rare, unique cutaneous adnexal tumors. Sarcomatous transformation in MPPTs is even rarer (4 previous cases reported). Here, we report an extraordinary case of a MPPT with sarcomatous transformation occurring on the scalp of a 63-year-old man with an in-depth molecular profile along with histologic, immunohistochemical, and follow-up data. Shared mutations in the epithelial and sarcomatous components included a loss-of-function TP53 mutation. An inactivating TP53… Show more
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