Malignant primary pulmonary paraganglioma.

Abstract

The histological, immunocytochemical, and electron microscopic findings in a case of malignant primary pulmonary paraganglioma are reported. The existence of this rare tumour is evidence for the presence of pulmonary chemoreceptors. Case report A 49 year old nursing auxiliary, a non-smoker, presented with a three month history of pleuritic pain in the right shoulder and a cough with white sputum; she had noticed increased breathlessness during this period. On examination there were diminished breath sounds over the right upper lobe. A chest radiograph showed a shadow in the right upper lobe, which extended anteriorly to the pleura.Right anterior mediastinotomy through the second intercostal space disclosed a group of enlarged lymph nodes overlying the main pulmonary artery and a separate large mass within the right upper lobe of the lung. At bronchoscopy the anterior segment of the right upper lobe bronchus was found to be obstructed. Endobronchial biopsy specimens showed no mucosal abnormality. As no other primary lesion was found the patient underwent a right pneumonectomy through the fifth intercostal space. A tumour occupied the greater part of the right upper lobe: a mass of enlarged subcarinal and paratracheal nodes surrounded the main bronchus and extended round the right pulmonary artery. The right lung and the enlarged nodes were excised and she made an uneventful recovery. Repeat computed tomography at three months showed no recurrence. She remains well with

Pulmonales Paragangliom: Fallbericht und Literaturübersicht

“…B. Thoraxschmerzen aufgrund der Tumorgröße und -lage [8,9]. Nur in drei Fällen wurde präoperativ endobronchiales Fremdgewebe gesehen und biopsiert [10 -12], aber nur in einem dieser Fälle konnte anhand der Biopsie die korrekte Diagnose gestellt werden [12]. Abb.…”

Fine Needle Aspiration Cytology of Primary Pulmonary Paraganglioma

“…7,8,13,17 The age range was 18-69 years, and the mean age was 48. Eight patients, including the present one, were asymptomatic.…”

Primary Pulmonary Paraganglioma: Case Report and Literature Review

“…Malignant PPP is distinctly uncommon, with only 1 case having been reported in a 49-year-old woman. 2 She had lymph node metastases, but there was no evidence of distant metastases or any extrapulmonary involvement.…”

“…1 These tumors are usually located along the vascular tree, especially near the carotid body, the jugulotympanic body, or the mediastinal vessels. 2 While these low-grade tumors often occur in the superior or inferior para-aortic regions, there are reports of their presence in virtually every organ. However, the existence of paragangliomas as primary tumors of the lung remains controversial.…”

“…Association with pulmonary thromboemboli has been described in the adjacent blood vessel. [1][2][3][4] Clinical symptoms and malignant activity have not been noted. The second form of pulmonary paraganglioma is a large solid tumor in the lung parenchyma, which was first reported in 1958 by Heppleston.…”