Malignant Pleural Mesothelioma with Bone Marrow Metastases

Ihara, Hiroaki; Harada, Norihiro; Shimada, Naoki; Kanamori, Koichiro; Hayashi, Takuo; Uekusa, Toshimasa; Takahashi, Kazuhisa

doi:10.2169/internalmedicine.9246-17

Cited by 4 publications

(3 citation statements)

References 26 publications

(35 reference statements)

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“…MPM is generally considered a locally invasive tumor, and bone marrow metastasis from MPM is considered an extremely rare consequence ( 5 ). One study of postmortem records of 318 patients with MPM revealed that tumors were detected in extrathoracic organs in 55.4% of the cases, and almost all organs were involved including the liver (31.9%), spleen (10.8%), thyroid (6.9%), and brain (3.0%).…”

Section: Discussionmentioning

confidence: 99%

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Cellular cannibalism and consequent thrombocytopenia in a patient with bone marrow metastasis of malignant pleural mesothelioma: A case report

et al. 2021

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Cellular cannibalism is a tumor activity where a cell is engulfed by another cell. This process promotes tumor cell survival under unfavorable conditions. The current report describes an extremely rare case of thrombocytopenia resulting from cellular cannibalism in a patient with bone marrow metastasis due to malignant pleural mesothelioma (MPM). A 77-year-old male presented with hemothorax and thrombocytopenia. He was diagnosed with MPM of the sarcomatoid cell type. However, his disease progressed rapidly and he died 11 days after admission. Bone marrow aspiration revealed metastatic MPM cells that had engulfed other blood cells. Accordingly, the observed thrombocytopenia was attributed to cellular cannibalism by metastatic MPM tumor cells. To the best of our knowledge, this is the first reported case of thrombocytopenia due to cellular cannibalism in a patient with this type of malignancy (MPM). The results suggested that although MPM rarely metastasizes to the bone marrow, bone marrow aspiration could be useful in such cases.

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Section: Discussionmentioning

confidence: 99%

“…Metastasis to the bone marrow most commonly arises from prostate, breast, and lung cancers and neuroblastoma ( 4 ). In contrast, bone marrow metastasis due to MPM is very rare ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Cellular cannibalism and consequent thrombocytopenia in a patient with bone marrow metastasis of malignant pleural mesothelioma: A case report

et al. 2021

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“…Immunotherapy of MESO exhibits satisfactory clinical outcomes as well [ 12 ]. Bone metastasis is a rare but much more serious feature in MESO [ 13 , 14 ]. Hence, it is of high clinical significance to elucidate immune-related molecular mechanisms that are associated with MESO bone metastasis, which will aid in the amelioration of individualized therapeutic methods for advanced patients.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Bone Metastasis-Associated Immune-Related Genes Regulated by Transcription Factors in Mesothelioma

Hao

Wang

Zheng

et al. 2022

BioMed Research International

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Mesothelioma (MESO) is a mesothelial originate neoplasm with high morbidity and mortality. Despite advancement in technology, early diagnosis still lacks effectivity and is full of pitfalls. Approaches of cancer diagnosis and therapy utilizing immune biomarkers and transcription factors (TFs) have attracted more and more attention. But the molecular mechanism of these features in MESO bone metastasis has not been thoroughly studied. Utilizing high-throughput genome sequencing data and lists of specific gene subsets, we performed several data mining algorithm. Single-sample Gene Set Enrichment Analysis (ssGSEA) was applied to identify downstream immune cells. Potential pathways involved in MESO bone metastasis were identified using Gene Oncology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Gene Set Variation Analysis (GSVA), Gene Set Enrichment Analysis (GSEA), and Cox regression analysis. Ultimately, a model to help early diagnosis and to predict prognosis was constructed based on differentially expressed immune-related genes between bone metastatic and nonmetastatic MESO groups. In conclusion, immune-related gene SDC2, regulated by TFs TCF7L1 and POLR3D, had an important role on immune cell function and infiltration, providing novel biomarkers and therapeutic targets for metastatic MESO.

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A challenging diagnosis of malignant mesothelioma with osteosarcomatous differentiation metastasizing to bone

Brown

Jersmann

Crowhurst

et al. 2020

Respirology Case Reports

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Malignant pleural mesothelioma (MPM) is an insidious primary neoplasm of the pleura that can be challenging to diagnose and is commonly considered to be only locally invasive. We present the case of a 74-year-old male who presented with clinical features of MPM but from whom pleural fluid and biopsies initially suggested benign pathology. He later developed diffuse bony metastases and re-examination of pleural biopsies using modern immunohistochemistry and molecular testing revealed a diagnosis of sarcomatoid and desmoplastic MPM with heterologous osteosarcomatous differentiation. This case not only demonstrates the rare potential of skeletal metastasis of MPM, but also highlights the importance of recognizing the utility of modern diagnostic tests and their potential to prevent the need for unnecessary invasive procedures. To our knowledge this is the first description of this rare histological sub-type presenting with skeletal metastases.

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Malignant Pleural Mesothelioma with Bone Marrow Metastases

Cited by 4 publications

References 26 publications

Cellular cannibalism and consequent thrombocytopenia in a patient with bone marrow metastasis of malignant pleural mesothelioma: A case report

Cellular cannibalism and consequent thrombocytopenia in a patient with bone marrow metastasis of malignant pleural mesothelioma: A case report

Prognostic Bone Metastasis-Associated Immune-Related Genes Regulated by Transcription Factors in Mesothelioma

A challenging diagnosis of malignant mesothelioma with osteosarcomatous differentiation metastasizing to bone

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