Malignant pleural mesothelioma (MPM) is a rare and extremely aggressive intrathoracic neoplasm that emerges from the mesothelial cells that line the ribs and the membrane that envelopes the lungs. We present the case of a 68-year-old male with complaints of breathlessness and fatigue. He had no history of exposure to asbestos and no association with familial exposure either. He was evaluated with a PET-CT scan, pleural cytology, and immunohistochemistry and was diagnosed with Malignant Pleural Mesothelioma. The patient was managed with chemotherapy, radiotherapy, and palliative care. A detailed report of malignant pleural mesothelioma was presented in this study.