Malignant Pleural Mesothelioma Epidemiology in the United States From 2000 to 2016

Thomas, Akesh; Karakattu, Sajin; Cagle, Jeanette; Hoskere, Girendra

doi:10.7759/cureus.14605

Cited by 4 publications

(7 citation statements)

References 18 publications

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“…The incidence and mortality mesothelioma rates are consistent with trends in asbestos exposure due to the strong causal link between asbestos and mesothelioma [28]. Studies have revealed that the time of the law's implementation prohibiting the use of asbestos has an impact on these rates as well [10,[29][30][31]. MM incidence trends differ between European nations.…”

Section: Discussionmentioning

confidence: 60%

“…In Europe, pleural mesothelioma incidence rates are still rising, while certain countries have seen an overal decline [28,29]. In countries where the law banned the use of asbestos was adopted early, studies have indicated a decrease in the incidence and mortality rates of MM [10,[29][30][31]. Research that investigated nations with high cumulative asbestos consumption (> 2 million tons) between 1933 and 2012 found an overall, distinct linear correlation between the total amount of asbestos consumed and the total number of mesothelioma deaths [32].…”

Section: Introductionmentioning

confidence: 99%

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Asbestos ban policies and mesothelioma mortality in Greece

Gogou,

Hatzoglou,

Siachpazidou

et al. 2024

BMC Public Health

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Background Malignant mesothelioma is a rare form of cancer that mostly affects the pleura and has a strong link to asbestos exposure. Greece banned the use of asbestos in 2005, however, the public was already aware of this substance in the 1980s. This research aims to present an overview of Greece’s mesothelioma age-standardized mortality rates (ASMR) from 1983 to 2019 by age, gender, and geographic region and to determine whether the actions to ban asbestos impacted these rates. Methods Data were retrieved by the Hellenic Statistical Authority (HSA) from death certificates that mentioned mesothelioma as the cause of death from 1983 to 2019 with details on the residence, gender, and age. Statistical analysis was performed using PRISM 6.0 software, a two-way ANOVA test, Trend analysis was conducted using Joinpoint Regression Program 5.0 software. The linear and non-linear model was used to calculate the age-standardized rates of annual percentage change (APC) and its 95% confidential interval (95% CI). Results From 1983 to 2019, 850 total mesothelioma deaths were recorded, the majority of whom were males (634). A rate of 74.6% accounts for males and 25.4% for females, and the ratio of Males: Females was 3:1. Males’ ASMR and the whole population’s ASMR reached their highest levels in 2011 (0.93/100000person-years and 0.53/100000person-years, respectively). To look for potential changes between the first two decades of the 21st century, we compared the mean ASMR of each geographic region in Greece between two different 10-year subperiods (2000–2009 and 2010–2019). Except for Epirus, all regions of Greece had elevated regional ASMRs, particularly in those with the highest asbestos deposits. Notably, the ASMR in Epirus decreased from 0.54/100000person-years (2000–2009) to 0.31/100000person-years (2010–2019). After 2011, the ASMR for men and the general population stabilized. This stability is important since mesothelioma in men is associated with occupational asbestos exposure. The intriguing discovery of a lower ASMR in Epirus emphasizes the need to raise awareness of the condition and implement effective public health measures. Conclusions In Greece, the annual ASMR for males and the whole population reached its highest level in 2011, which is positive and encouraging and may be a sign that the rate will stabilize during the following years. Moreover, this study showed that the actions made in the 1980s regarding public awareness and surveillance directly impacted the decrease in Epirus rates. Future research, continual awareness, information, and recording are needed to monitor the mesothelioma epidemic. The possible benefit of a mesothelioma registry and the epidemiological surveillance of asbestos-related diseases, particularly mesothelioma mortality, need to be addressed. Trial registration Not applicable.

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Asbestos ban policies and mesothelioma mortality in Greece

Gogou,

Hatzoglou,

Siachpazidou

et al. 2024

BMC Public Health

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“…MM is a heterogeneous tumor that includes the following three major histologic subtypes: epithelioid, sarcomatoid and biphasic. The epithelioid subtype is the most common type of mesothelioma, and it has a better prognosis than the other subtypes [ 4 ]. The median overall survival is approximately 1 year in patients with advanced surgically unresectable mesothelioma, and the 5-year overall survival (OS) is approximately 10% [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Systemic characterization of alternative splicing related to prognosis and immune infiltration in malignant mesothelioma

Lai

Yang

2021

BMC Cancer

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Background Malignant mesothelioma (MM) is a relatively rare and highly lethal tumor with few treatment options. Thus, it is important to identify prognostic markers that can help clinicians diagnose mesothelioma earlier and assess disease activity more accurately. Alternative splicing (AS) events have been recognized as critical signatures for tumor diagnosis and treatment in multiple cancers, including MM. Methods We systematically examined the AS events and clinical information of 83 MM samples from TCGA database. Univariate Cox regression analysis was used to identify AS events associated with overall survival. LASSO analyses followed by multivariate Cox regression analyses were conducted to construct the prognostic signatures and assess the accuracy of these prognostic signatures by receiver operating characteristic (ROC) curve and Kaplan–Meier survival analyses. The ImmuCellAI and ssGSEA algorithms were used to assess the degrees of immune cell infiltration in MM samples. The survival-related splicing regulatory network was established based on the correlation between survival-related AS events and splicing factors (SFs). Results A total of 3976 AS events associated with overall survival were identified by univariate Cox regression analysis, and ES events accounted for the greatest proportion. We constructed prognostic signatures based on survival-related AS events. The prognostic signatures proved to be an efficient predictor with an area under the curve (AUC) greater than 0.9. Additionally, the risk score based on 6 key AS events proved to be an independent prognostic factor, and a nomogram composed of 6 key AS events was established. We found that the risk score was significantly decreased in patients with the epithelioid subtype. In addition, unsupervised clustering clearly showed that the risk score was associated with immune cell infiltration. The abundances of cytotoxic T (Tc) cells, natural killer (NK) cells and T-helper 17 (Th17) cells were higher in the high-risk group, whereas the abundances of induced regulatory T (iTreg) cells were lower in the high-risk group. Finally, we identified 3 SFs (HSPB1, INTS1 and LUC7L2) that were significantly associated with MM patient survival and then constructed a regulatory network between the 3 SFs and survival-related AS to reveal potential regulatory mechanisms in MM. Conclusion Our study provided a prognostic signature based on 6 key events, representing a better effective tumor-specific diagnostic and prognostic marker than the TNM staging system. AS events that are correlated with the immune system may be potential therapeutic targets for MM.

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“…Its global incidence has steadily increased, despite expectations that it would peak in 2020 1. Most cases are attributable to asbestos exposure;2 however, the latency period between exposure and development of DPM can range from 15 to 60 years and a clinical history of asbestos exposure is not always obtained 3,4. The prognosis of DPM is dismal, with reported median overall survival of only 9 to 12 months 5.…”

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confidence: 99%

“…1 Most cases are attributable to asbestos exposure; 2 however, the latency period between exposure and development of DPM can range from 15 to 60 years and a clinical history of asbestos exposure is not always obtained. 3,4 The prognosis of DPM is dismal, with reported median overall survival of only 9 to 12 months. 5 There have been minimal improvements in outcome, even in the small minority of patients eligible for surgical resection.…”

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confidence: 99%

A Critical Assessment of Current Grading Schemes for Diffuse Pleural Mesothelioma With a Proposal for a Novel Mesothelioma Weighted Grading Scheme (MWGS)

Fuchs

Chou

Aksoy

et al. 2021

American Journal of Surgical Pathology

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Although there is early support for schemes based on nuclear grade, necrosis and mitotic rate, there is currently no widely implemented grading system for diffuse pleural mesothelioma (DPM). We investigated current systems and propose a novel Mesothelioma Weighted Grading Scheme (MWGS). The MWGS assigns weighted scores from 0 to 10 based on age ( ≤ 74, > 74 yrs: 0,1); histologic type (epithelioid, biphasic, sarcomatoid: 0,1,2); necrosis (absent, present: 0,2); mitotic count per 2 mm 2 ( ≤ 1, 2 to 4, ≥ 5: 0,1,2); nuclear atypia (mild, moderate, severe: 0,1,2); and BRCA1-associated protein 1 (BAP1) expression (lost, retained: 0,1). A score of 0 to 3 is low grade, 4 to 6 intermediate grade, and 7 to 10 high grade. In 369 consecutive DPMs, median survival was 17.1, 10.1, and 4.1 months for low, intermediate, and high grades (P < 0.0001). A progressive increase in score correlated with worsening overall survival (P < 0.0001). Interobserver concordance was substantial (κ = 0.588), with assessment of nuclear grade being the most subjective parameter (κ = 0.195). We compared the MWGS to the 2-tiered system discussed in the World Health Organization (WHO) fifth edition. The WHO system predicted median survival in epithelioid (median 18.0 vs. 11.3 mo, P = 0.003) and biphasic (16.2 vs. 4.2 mo, P = 0.002), but not sarcomatoid DPM (5.4 vs. 4.7 mo, P = 0.407). Interestingly, the WHO grading system was prognostic in cases with BAP1 loss (median survival 18.7 vs. 10.4 mo, P < 0.0001), but not retained BAP1 expression (8.9 vs. 6.2 mo, P = 0.061). In conclusion, the WHO scheme has merit in epithelioid/biphasic and BAP1-deficient DPM, however, the MWGS can be used for risk stratification of all DPMs, regardless of histologic subtype and BAP1 status.

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Malignant Pleural Mesothelioma Epidemiology in the United States From 2000 to 2016

Cited by 4 publications

References 18 publications

Asbestos ban policies and mesothelioma mortality in Greece

Asbestos ban policies and mesothelioma mortality in Greece

Systemic characterization of alternative splicing related to prognosis and immune infiltration in malignant mesothelioma

A Critical Assessment of Current Grading Schemes for Diffuse Pleural Mesothelioma With a Proposal for a Novel Mesothelioma Weighted Grading Scheme (MWGS)

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