Malignant Pleural Mesothelioma: Clinicopathologic and Survival Characteristic in a Consecutive Series of 40 Patients

Abstract

Introduction: Pleural malignant mesothelioma is an uncommon but extremely invasive tumor which originates from mesothelial cells and usually occurs after prolonged exposure to asbestos. Different types of surgical and oncological therapeutic methods have been used resulting in various outcomes. The aim of this study was to evaluate, clinicopathologically, 40 patients with pleural malignant mesothelioma and the main factors influencing their prognosis. Methods: In this study, 40 patients with a definitive diagnosis, who had been followed up for at least 3 years were studied according to these: epidemiologic factors, stage and pathological types, treatment method and complications, and by using factors that influence patients survival, we evaluated them statistically. Results: The M/F ratio was l3/1 with an average age of 55 years. Chest pain was the most common symptom. In 55% of patients, the lesions were localized in the left site and most were in Buchart stage I or II. The epithelial form was the most common pathological pattern (62.5%). 47.5% of patients only received radiotherapy and chemotherapy. Of patients who underwent decortication and pleurectomy with adjuvant therapy, extrapleural was performed in 20% of patients, and pneumonectomy, in 17.5%; and 15% refused any type of treatment. One patient died from the surgery. The most common surgical complication was wound infection. The average survival was 10.5 months, and the main factors influencing the survival were physiologic status, pathological form of disease, stage of disease and the pattern of pleural involvement. Conclusion: Because of the low survival after multimodality invasive treatments in mesothelioma, aggressive therapeutic methods were recommended in patients with good physiological status and early clinical stage with a good pathology type.

Prognostic nutritional index predicts postoperative complications and long-term outcomes of gastric cancer

“…In our study, the percentage of patients aged 65 years or older was higher in the PNI-low group than in the PNI-high group (P = 0.019). Many studies had demonstrated that advanced age is an independent adverse predictor of survival for cancer patients [21,22] , but we failed to find the relationship between prognosis and age in our study cohort. The present study demonstrated that the PNI was significantly lower in patients with features of more advanced tumors, such as deeper depth of invasion and positive lymph node metastasis, than in those without such factors.…”

Environmental and Occupational Risk Factors and Predictors of Survival Among Malignant Pleural Mesothelioma Patients

“…Moreover, Bagheri et al (2011) reported that while there was a significant relationship between survival and age, there was no significant relationship between survival and therapeutic plan. On the contrary, Akl et al (2010) reported statistically significant differences in survival time between patients subjected to different surgery, supportive treatment, chemotherapy and combined (chemotherapy and surgery).…”

Pleural Mesothelioma: An Institutional Experience of 66 Cases

“…In most industrialized countries, more than 90% of pleural mesotheliomas in men are related to prior asbestos exposure 11. On the other hand, only 25% of patients with malignant mesothelioma had a history of asbestos exposure in one study from Iran 20. In Korea, an average of 34 cases have been reported annually in the mesothelioma surveillance system data since 2001 21.…”